SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pdz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7B_A_HLTA4003_1 (SERUM ALBUMIN)	2pdz	SYNTROPHIN (Mus musculus)	5 / 9	ILE A 28 LEU A 45 VAL A 54 ALA A 67 LEU A 71	None	1.15A	1e7bA-2pdzA: undetectable	1e7bA-2pdzA: 9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BU8_A_TF4A1379_1 (PYRUVATE DEHYDROGENASE KINASE ISOENZYME 2)	2pdz	SYNTROPHIN (Mus musculus)	4 / 8	LEU A 45 ILE A 51 ILE A 16 ILE A 18	None	0.81A	2bu8A-2pdzA: undetectable	2bu8A-2pdzA: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_C_ACTC800_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	2pdz	SYNTROPHIN (Mus musculus)	3 / 3	ASP A 10 ARG A 7 ALA A 9	None	0.80A	3mbgC-2pdzA: undetectable	3mbgC-2pdzA: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NRR_A_D16A520_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2pdz	SYNTROPHIN (Mus musculus)	5 / 12	LEU A 80 ILE A 28 PRO A 27 LEU A 71 THR A 42	None	1.10A	3nrrA-2pdzA: undetectable	3nrrA-2pdzA: 11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NRR_B_D16B520_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2pdz	SYNTROPHIN (Mus musculus)	5 / 12	LEU A 80 ILE A 28 PRO A 27 LEU A 71 THR A 42	None	1.13A	3nrrB-2pdzA: undetectable	3nrrB-2pdzA: 11.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E7B_A_HLTA4003_1","SERUM ALBUMIN","2pdz","SYNTROPHIN","Mus musculus",5,"ILE A  28;LEU A  45;VAL A  54;ALA A  67;LEU A  71","None","1.15A","1e7bA-2pdzA:undetectable","1e7bA-2pdzA:9.82"],["2BU8_A_TF4A1379_1","PYRUVATE DEHYDROGENASE KINASE ISOENZYME 2","2pdz","SYNTROPHIN","Mus musculus",4,"LEU A  45;ILE A  51;ILE A  16;ILE A  18","None","0.81A","2bu8A-2pdzA:undetectable","2bu8A-2pdzA:13.58"],["3MBG_C_ACTC800_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","2pdz","SYNTROPHIN","Mus musculus",3,"ASP A  10;ARG A   7;ALA A   9","None","0.80A","3mbgC-2pdzA:undetectable","3mbgC-2pdzA:20.90"],["3NRR_A_D16A520_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","2pdz","SYNTROPHIN","Mus musculus",5,"LEU A  80;ILE A  28;PRO A  27;LEU A  71;THR A  42","None","1.10A","3nrrA-2pdzA:undetectable","3nrrA-2pdzA:11.71"],["3NRR_B_D16B520_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","2pdz","SYNTROPHIN","Mus musculus",5,"LEU A  80;ILE A  28;PRO A  27;LEU A  71;THR A  42","None","1.13A","3nrrB-2pdzA:undetectable","3nrrB-2pdzA:11.71"]]