SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pe4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 8 TYR A 339
LEU A 303
THR A  34
VAL A  55
 None
 1.15A 1dz9A-2pe4A:
undetectable		 1dz9A-2pe4A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 8 TYR A 339
LEU A 303
THR A  34
VAL A  55
 None
 1.15A 1o76B-2pe4A:
undetectable		 1o76B-2pe4A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 8 TYR A 339
LEU A 303
THR A  34
VAL A  55
 None
 1.19A 1uyuA-2pe4A:
undetectable		 1uyuA-2pe4A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 6 ARG A 194
LEU A 193
PHE A 110
LEU A 114
 None
 1.00A 3abkP-2pe4A:
undetectable
3abkW-2pe4A:
undetectable		 3abkP-2pe4A:
21.24
3abkW-2pe4A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 5 PRO A 249
ILE A 225
TRP A 141
PHE A 212
 None
 1.24A 3topB-2pe4A:
3.9		 3topB-2pe4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 6 ARG A 194
LEU A 193
PHE A 110
LEU A 114
 None
 1.03A 3wg7P-2pe4A:
undetectable
3wg7W-2pe4A:
undetectable		 3wg7P-2pe4A:
21.24
3wg7W-2pe4A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		5 / 12 SER A 310
LEU A 382
VAL A 351
GLY A 354
ALA A 355
 None
NAG  A 550 (-4.4A)
None
None
None
 1.13A 4coxA-2pe4A:
undetectable		 4coxA-2pe4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		5 / 12 SER A 310
LEU A 382
VAL A 351
GLY A 354
ALA A 355
 None
NAG  A 550 (-4.4A)
None
None
None
 1.14A 4coxB-2pe4A:
undetectable		 4coxB-2pe4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		5 / 12 SER A 310
LEU A 382
VAL A 351
GLY A 354
ALA A 355
 None
NAG  A 550 (-4.4A)
None
None
None
 1.13A 4coxD-2pe4A:
undetectable		 4coxD-2pe4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 7 PHE A 290
ALA A  38
THR A  40
LEU A 344
 None
 0.92A 4ejgA-2pe4A:
undetectable		 4ejgA-2pe4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 7 VAL A 127
ILE A 128
LEU A 232
LEU A 235
 None
 1.05A 4l1wA-2pe4A:
7.5		 4l1wA-2pe4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		5 / 12 LEU A 379
LEU A 382
VAL A 351
GLY A 354
ALA A 355
 None
NAG  A 550 (-4.4A)
None
None
None
 0.94A 4rrwD-2pe4A:
undetectable		 4rrwD-2pe4A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		5 / 12 LEU A 379
LEU A 382
VAL A 351
GLY A 354
ALA A 355
 None
NAG  A 550 (-4.4A)
None
None
None
 0.94A 4rrzD-2pe4A:
undetectable		 4rrzD-2pe4A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 6 PHE A 347
PRO A 346
THR A 352
ILE A 348
 None
 1.32A 5ih0A-2pe4A:
undetectable		 5ih0A-2pe4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		3 / 3 VAL A  58
ARG A 240
PRO A 282
 None
 0.84A 5koxA-2pe4A:
undetectable		 5koxA-2pe4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		5 / 10 ALA A 355
THR A 352
ALA A 316
GLY A 317
ALA A 311
 None
 1.16A 5lf3H-2pe4A:
undetectable
5lf3I-2pe4A:
undetectable		 5lf3H-2pe4A:
20.39
5lf3I-2pe4A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		5 / 10 ALA A 355
THR A 352
ALA A 316
GLY A 317
ALA A 311
 None
 1.18A 5lf3V-2pe4A:
undetectable
5lf3W-2pe4A:
undetectable		 5lf3V-2pe4A:
20.39
5lf3W-2pe4A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		5 / 11 ALA A 355
ALA A 316
GLY A 317
ALA A 311
LEU A 303
 None
 1.13A 5lf7H-2pe4A:
undetectable
5lf7I-2pe4A:
undetectable		 5lf7H-2pe4A:
20.39
5lf7I-2pe4A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		5 / 11 ALA A 355
ALA A 316
GLY A 317
ALA A 311
LEU A 303
 None
 1.11A 5lf7V-2pe4A:
undetectable
5lf7W-2pe4A:
undetectable		 5lf7V-2pe4A:
20.39
5lf7W-2pe4A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2pe4 HYALURONIDASE-1
(Homo
sapiens) 		4 / 5 ARG A 194
LEU A 193
PHE A 110
LEU A 114
 None
 1.03A 5x19C-2pe4A:
undetectable
5x19J-2pe4A:
undetectable		 5x19C-2pe4A:
21.24
5x19J-2pe4A:
8.29