SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		4 / 8 ASP A 206
ASP A 203
TYR A 356
THR A 384
 None
 1.37A 1ceaA-2pefA:
undetectable
1ceaB-2pefA:
undetectable		 1ceaA-2pefA:
13.02
1ceaB-2pefA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 ASN A 286
ILE A 289
LEU A 420
ASN A  73
THR A 418
 None
 1.17A 1likA-2pefA:
undetectable		 1likA-2pefA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		4 / 7 ILE A 298
GLY A 294
PRO A 413
ASN A  62
 None
 0.99A 1oniG-2pefA:
undetectable
1oniI-2pefA:
undetectable		 1oniG-2pefA:
16.67
1oniI-2pefA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 313
PHE A 401
ASN A  80
LEU A  82
TYR A 267
 None
 1.13A 1u72A-2pefA:
undetectable		 1u72A-2pefA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A 357
ALA A 336
MET A 107
ALA A 110
LEU A 328
 None
 1.09A 2h77A-2pefA:
undetectable		 2h77A-2pefA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  92
SER A  74
ILE A 322
ALA A  88
LEU A 331
 None
 1.23A 2japA-2pefA:
undetectable		 2japA-2pefA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  92
SER A  74
ILE A 322
ALA A  88
LEU A 331
 None
 1.20A 2japB-2pefA:
undetectable		 2japB-2pefA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A  92
SER A  74
ILE A 322
ALA A  88
LEU A 331
 None
 1.22A 2japD-2pefA:
undetectable		 2japD-2pefA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 313
PHE A 401
ASN A  80
LEU A  82
TYR A 267
 None
 1.12A 2w3bB-2pefA:
undetectable		 2w3bB-2pefA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		4 / 5 LEU A 139
TYR A 267
ILE A 405
ALA A 375
 None
 0.91A 3n8yB-2pefA:
undetectable		 3n8yB-2pefA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A 162
ASN A 212
VAL A 378
ILE A 198
ILE A 145
 None
 1.17A 3ohtA-2pefA:
undetectable
3ohtB-2pefA:
undetectable		 3ohtA-2pefA:
20.48
3ohtB-2pefA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 10 ILE A 198
ILE A 145
ILE A 162
ASN A 212
VAL A 378
 None
 1.16A 3ohtA-2pefA:
undetectable
3ohtB-2pefA:
undetectable		 3ohtA-2pefA:
20.48
3ohtB-2pefA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 313
PHE A 401
ASN A  80
LEU A  82
TYR A 267
 None
 1.14A 4kebB-2pefA:
undetectable		 4kebB-2pefA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 9 VAL A 368
TYR A 267
ALA A 375
PHE A 274
ILE A 405
 None
 1.36A 4oknB-2pefA:
undetectable		 4oknB-2pefA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		4 / 4 ILE A 183
ASN A 184
ILE A 195
VAL A 378
 None
 1.09A 4uy87-2pefA:
undetectable		 4uy87-2pefA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		4 / 6 LEU A 422
LYS A 315
PRO A 314
GLU A 245
 None
 1.25A 4z4gA-2pefA:
undetectable		 4z4gA-2pefA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A 357
ALA A 336
MET A 107
ALA A 110
LEU A 328
 None
 1.01A 4zo1X-2pefA:
undetectable		 4zo1X-2pefA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		4 / 5 ALA A  88
PRO A 413
GLY A 262
LEU A 292
 None
 1.00A 5eslA-2pefA:
undetectable		 5eslA-2pefA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 10 ILE A 357
THR A 379
LEU A  92
PHE A 344
LEU A 210
 None
 1.20A 5fhzC-2pefA:
undetectable		 5fhzC-2pefA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 8 ILE A  68
LEU A 292
ILE A 298
ASN A 411
SER A 273
 None
 1.17A 5numA-2pefA:
undetectable		 5numA-2pefA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 10 LEU A  82
ALA A 375
PRO A  85
SER A  67
PHE A 297
 None
 1.21A 6b89A-2pefA:
undetectable		 6b89A-2pefA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		5 / 10 LEU A  82
ALA A 375
PRO A  85
SER A  67
PHE A 297
 None
 1.29A 6b89B-2pefA:
undetectable		 6b89B-2pefA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2pef SERINE PROTEASE
INHIBITOR
(Caldanaerobacter
subterraneus) 		3 / 3 PHE A 246
ARG A 399
ALA A 276
 None
 0.99A 6ecfB-2pefA:
undetectable		 6ecfB-2pefA:
21.67