SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_B_AZMB900_1
(MURINE CARBONIC
ANHYDRASE V)		 2pes URICASE
(Aspergillus
flavus) 		5 / 12 VAL A 248
TYR A 250
THR A 207
THR A 210
TRP A 188
 None
 1.17A 1dmyB-2pesA:
undetectable		 1dmyB-2pesA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ARG A 128
ILE A 142
TRP A 188
 None
 0.96A 1m8eB-2pesA:
undetectable		 1m8eB-2pesA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ARG A 128
ILE A 142
TRP A 188
 None
 0.94A 1nodB-2pesA:
undetectable		 1nodB-2pesA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ARG A 128
ILE A 142
TRP A 188
 None
 0.87A 1qomA-2pesA:
undetectable		 1qomA-2pesA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ASP A 141
VAL A 130
PRO A  75
 None
 0.78A 2avvA-2pesA:
undetectable		 2avvA-2pesA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ARG A 128
ILE A 142
TRP A 188
 None
 0.95A 2nodB-2pesA:
undetectable		 2nodB-2pesA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ARG A 128
ILE A 142
TRP A 188
 None
 1.00A 3e68A-2pesA:
undetectable		 3e68A-2pesA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ARG A 128
ILE A 142
TRP A 188
 None
 0.95A 3e6tB-2pesA:
undetectable		 3e6tB-2pesA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ARG A 128
ILE A 142
TRP A 188
 None
 0.74A 3e7iB-2pesA:
undetectable		 3e7iB-2pesA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ARG A 128
ILE A 142
TRP A 188
 None
 0.86A 3nw2A-2pesA:
undetectable		 3nw2A-2pesA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2pes URICASE
(Aspergillus
flavus) 		3 / 3 ARG A 128
ILE A 142
TRP A 188
 None
 0.85A 3nw2B-2pesA:
undetectable		 3nw2B-2pesA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2pes URICASE
(Aspergillus
flavus) 		4 / 6 ASP A 183
GLY A 148
ASP A 181
THR A 180
 None
 1.10A 3vqrA-2pesA:
undetectable		 3vqrA-2pesA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2pes URICASE
(Aspergillus
flavus) 		4 / 5 ASP A 183
GLY A 148
ASP A 181
THR A 180
 None
 1.09A 3vqrB-2pesA:
undetectable		 3vqrB-2pesA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2pes URICASE
(Aspergillus
flavus) 		4 / 7 ASP A 133
GLY A  84
THR A  85
ILE A  88
 None
 0.84A 4acaC-2pesA:
undetectable		 4acaC-2pesA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2pes URICASE
(Aspergillus
flavus) 		4 / 6 ILE A 142
SER A 199
PHE A 204
LEU A  78
 None
 0.96A 4m51A-2pesA:
undetectable		 4m51A-2pesA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 2pes URICASE
(Aspergillus
flavus) 		4 / 8 ASN A 254
PHE A 258
GLU A 259
THR A 150
 AZA  A 300 (-4.4A)
None
None
None
 1.21A 5hqaA-2pesA:
undetectable		 5hqaA-2pesA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 2pes URICASE
(Aspergillus
flavus) 		5 / 12 GLY A 137
GLY A 139
HIS A  86
GLU A  89
VAL A  36
 None
 1.00A 5wz1A-2pesA:
undetectable		 5wz1A-2pesA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 2pes URICASE
(Aspergillus
flavus) 		5 / 12 GLY A 137
GLY A 139
HIS A  86
GLU A  89
VAL A  36
 None
 0.98A 5wz1C-2pesA:
undetectable		 5wz1C-2pesA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 2pes URICASE
(Aspergillus
flavus) 		5 / 12 GLY A 137
GLY A 139
HIS A  86
GLU A  89
VAL A  36
 None
 1.00A 5wz1D-2pesA:
undetectable		 5wz1D-2pesA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 2pes URICASE
(Aspergillus
flavus) 		5 / 12 GLY A 137
GLY A 139
HIS A  86
GLU A  89
VAL A  36
 None
 0.97A 5wz1E-2pesA:
undetectable		 5wz1E-2pesA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 2pes URICASE
(Aspergillus
flavus) 		5 / 12 GLY A 137
GLY A 139
HIS A  86
GLU A  89
VAL A  36
 None
 0.99A 5wz1F-2pesA:
undetectable		 5wz1F-2pesA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 2pes URICASE
(Aspergillus
flavus) 		5 / 12 GLY A 137
GLY A 139
HIS A  86
GLU A  89
VAL A  36
 None
 0.99A 5wz1G-2pesA:
undetectable		 5wz1G-2pesA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 2pes URICASE
(Aspergillus
flavus) 		5 / 12 GLY A 137
GLY A 139
HIS A  86
GLU A  89
VAL A  36
 None
 0.98A 5wz1H-2pesA:
undetectable		 5wz1H-2pesA:
22.60