SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pet'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN
(Homo
sapiens) 		5 / 11 ARG A 109
GLY A  87
VAL A  86
GLU A  89
ARG A  40
 None
 1.42A 2ac7A-2petA:
undetectable
2ac7B-2petA:
undetectable		 2ac7A-2petA:
22.14
2ac7B-2petA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN
(Homo
sapiens) 		5 / 11 ARG A  40
ARG A 109
GLY A  87
VAL A  86
GLU A  89
 None
 1.41A 2ac7A-2petA:
undetectable
2ac7B-2petA:
undetectable		 2ac7A-2petA:
22.14
2ac7B-2petA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN
(Homo
sapiens) 		4 / 5 LEU A 191
PRO A 123
ALA A 139
ILE A 138
 None
 0.83A 2aofB-2petA:
undetectable		 2aofB-2petA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN
(Homo
sapiens) 		4 / 6 PRO A  24
HIS A  28
ASP A  29
TYR A  31
 None
 1.45A 2lh8A-2petA:
undetectable		 2lh8A-2petA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN
(Homo
sapiens) 		5 / 12 LEU A   4
ALA A 104
LEU A  33
GLY A  99
HIS A  28
 None
 1.10A 3olsA-2petA:
undetectable		 3olsA-2petA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN
(Homo
sapiens) 		4 / 5 ARG A 200
LEU A 229
VAL A 130
ASP A 201
 None
 1.04A 3ufnA-2petA:
undetectable
3ufnB-2petA:
undetectable		 3ufnA-2petA:
15.95
3ufnB-2petA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN
(Homo
sapiens) 		4 / 5 LEU A  79
VAL A   6
VAL A  96
TYR A  92
 None
 0.94A 4r7iA-2petA:
undetectable		 4r7iA-2petA:
22.03