SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pey'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens) 		4 / 8 GLU A 108
ARG A 111
ARG A 112
LEU A  99
 None
 0.90A 1cmaA-2peyA:
undetectable
1cmaB-2peyA:
undetectable		 1cmaA-2peyA:
22.78
1cmaB-2peyA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens) 		5 / 11 LEU A 202
ALA A  63
ILE A 132
VAL A 156
VAL A 158
 None
DAT  A 300 (-4.3A)
ADX  A 400 (-3.9A)
None
None
 0.99A 2nnpB-2peyA:
undetectable		 2nnpB-2peyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens) 		4 / 8 SER A 133
PHE A 131
VAL A 116
LEU A  95
 None
ADX  A 400 (-4.7A)
None
None
 0.98A 3jq7C-2peyA:
5.2		 3jq7C-2peyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens) 		3 / 3 GLY A  62
GLY A  64
THR A  66
 DAT  A 300 (-3.2A)
DAT  A 300 (-3.2A)
DAT  A 300 (-3.6A)
 0.43A 3si7B-2peyA:
2.9		 3si7B-2peyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens) 		5 / 8 GLY A 184
SER A 190
GLY A 187
ILE A 132
LEU A  60
 ADX  A 400 (-4.8A)
None
None
ADX  A 400 (-3.9A)
None
 1.34A 3v1nA-2peyA:
2.5		 3v1nA-2peyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens) 		3 / 3 HIS A  79
VAL A  55
LEU A 220
 None
 0.77A 4m2vA-2peyA:
undetectable		 4m2vA-2peyA:
20.77