SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 141
LEU A  54
SER A  47
THR A  49
 None
 0.47A 1ictD-2pfcA:
undetectable		 1ictD-2pfcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 146
GLU A 176
LYS A 156
 None
 1.14A 3su9A-2pfcA:
undetectable		 3su9A-2pfcA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  93
PRO A  92
TYR A 110
ARG A  28
 None
 0.94A 3twpA-2pfcA:
undetectable		 3twpA-2pfcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 141
LEU A  54
SER A  47
THR A  49
 None
 0.83A 4d7bA-2pfcA:
undetectable		 4d7bA-2pfcA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 141
LEU A  54
SER A  47
THR A  49
 None
 0.86A 4ikiB-2pfcA:
undetectable		 4ikiB-2pfcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 141
LEU A  54
SER A  47
THR A  49
 None
 0.84A 4ikjA-2pfcA:
undetectable
4ikjB-2pfcA:
undetectable		 4ikjA-2pfcA:
18.85
4ikjB-2pfcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 141
LEU A  54
SER A  47
THR A  49
 None
 0.83A 4ikjA-2pfcA:
undetectable
4ikjB-2pfcA:
undetectable		 4ikjA-2pfcA:
18.85
4ikjB-2pfcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 141
LEU A  54
SER A  47
THR A  49
 None
 0.85A 4ikkA-2pfcA:
undetectable
4ikkB-2pfcA:
undetectable		 4ikkA-2pfcA:
18.85
4ikkB-2pfcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		4 / 7 GLN A  45
GLY A  57
GLN A 114
TYR A 110
 None
 0.99A 5vlmE-2pfcA:
undetectable		 5vlmE-2pfcA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  53
ALA A  89
LEU A 145
TYR A 110
ALA A  93
 None
 1.46A 6dk1B-2pfcA:
undetectable		 6dk1B-2pfcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  53
ALA A  89
LEU A 145
TYR A 110
ALA A  93
 None
 1.35A 6dk1C-2pfcA:
0.0		 6dk1C-2pfcA:
21.01