SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		5 / 12 GLY A 196
GLY A 193
GLY A 192
PHE A  45
LEU A 234
 None
None
AES  A1002 ( 3.8A)
None
None
 0.87A 1eizA-2pfeA:
undetectable		 1eizA-2pfeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		5 / 12 GLY A 196
GLY A 193
GLY A 192
PHE A  45
LEU A 234
 None
None
AES  A1002 ( 3.8A)
None
None
 0.85A 1ej0A-2pfeA:
undetectable		 1ej0A-2pfeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		3 / 3 GLU A 174
TYR A 171
PHE A  94
 None
 0.80A 1eqbB-2pfeA:
undetectable		 1eqbB-2pfeA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		3 / 3 GLU A 174
TYR A 171
PHE A  94
 None
 0.80A 1eqbA-2pfeA:
undetectable		 1eqbA-2pfeA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		3 / 3 GLU A 174
TYR A 171
PHE A  94
 None
 0.80A 1eqbD-2pfeA:
undetectable		 1eqbD-2pfeA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		3 / 3 GLU A 174
TYR A 171
PHE A  94
 None
 0.81A 1eqbC-2pfeA:
undetectable		 1eqbC-2pfeA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		5 / 12 THR A 178
GLY A 175
GLN A 229
ASP A 102
MET A 103
 None
 1.19A 1wg8A-2pfeA:
undetectable		 1wg8A-2pfeA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		5 / 12 THR A 178
GLY A 175
GLN A 229
ASP A 102
MET A 103
 None
 1.16A 1wg8B-2pfeA:
undetectable		 1wg8B-2pfeA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		4 / 5 GLY A  56
GLN A 229
VAL A 177
SER A 214
 None
 1.30A 1zzuA-2pfeA:
undetectable		 1zzuA-2pfeA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		5 / 12 LEU A 242
LEU A 235
GLY A 211
SER A 134
ALA A 130
 None
 1.12A 2br4C-2pfeA:
undetectable		 2br4C-2pfeA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		4 / 6 TRP A 157
LEU A 120
ARG A 120
GLY A 120
 None
 1.16A 2hs2B-2pfeA:
undetectable		 2hs2B-2pfeA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		3 / 3 GLY A 197
GLY A  18
GLY A  44
 None
 0.41A 3bogC-2pfeA:
undetectable		 3bogC-2pfeA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		3 / 3 GLY A 104
GLY A  59
GLY A  56
 None
 0.40A 3bogC-2pfeA:
undetectable		 3bogC-2pfeA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		4 / 5 PRO A  67
THR A 213
VAL A 212
GLY A 197
 None
AES  A1002 (-3.7A)
None
None
 1.15A 3elzA-2pfeA:
undetectable		 3elzA-2pfeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		5 / 11 ALA A  53
THR A  54
VAL A  47
ALA A  88
GLY A  89
 None
 0.92A 3mg0K-2pfeA:
undetectable
3mg0L-2pfeA:
undetectable		 3mg0K-2pfeA:
23.48
3mg0L-2pfeA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		6 / 12 ALA A  53
THR A  54
ALA A  55
VAL A  47
ALA A  88
GLY A  89
 None
 1.30A 3mg0Y-2pfeA:
undetectable
3mg0Z-2pfeA:
undetectable		 3mg0Y-2pfeA:
23.48
3mg0Z-2pfeA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		4 / 7 THR A 244
LEU A 235
ASN A 232
SER A 207
 None
 1.15A 4pfjA-2pfeA:
undetectable		 4pfjA-2pfeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		5 / 12 VAL A 136
THR A 213
ARG A 138
HIS A  57
GLY A 192
 None
AES  A1002 (-3.7A)
None
AES  A1002 (-4.8A)
AES  A1002 ( 3.8A)
 1.39A 4ydqB-2pfeA:
undetectable		 4ydqB-2pfeA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		3 / 3 PHE A 227
ILE A 225
ASP A 219
 GOL  A 403 ( 4.8A)
None
None
 0.74A 5cswA-2pfeA:
2.3		 5cswA-2pfeA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		3 / 3 PHE A 227
ILE A 225
ASP A 219
 GOL  A 403 ( 4.8A)
None
None
 0.74A 5cswB-2pfeA:
2.2		 5cswB-2pfeA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		5 / 12 VAL A 212
VAL A  47
VAL A 106
GLY A  89
LEU A 234
 None
 1.12A 5iktA-2pfeA:
undetectable		 5iktA-2pfeA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		5 / 11 THR A 201
VAL A  47
LEU A 242
ALA A 130
VAL A 212
 None
 1.32A 6dryA-2pfeA:
undetectable		 6dryA-2pfeA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 2pfe ALKALINE SERINE
PROTEASE
(Thermobifida
fusca) 		4 / 5 LEU A 120
THR A 120
THR A 244
GLY A 245
 None
 1.15A 6gtqA-2pfeA:
undetectable		 6gtqA-2pfeA:
20.00