SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.72A 1a7yA-2pffB:
undetectable		 1a7yA-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.80A 1a7yB-2pffB:
undetectable		 1a7yB-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1538
ILE A1641
GLY A1595
ALA A1596
LEU A1600
 None
 0.87A 1cqeA-2pffA:
undetectable		 1cqeA-2pffA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1538
ILE A1641
GLY A1595
ALA A1596
LEU A1600
 None
 0.87A 1cqeB-2pffA:
undetectable		 1cqeB-2pffA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 THR A1546
THR A1544
GLU A1553
THR A1556
 None
 1.31A 1d4fB-2pffA:
5.2		 1d4fB-2pffA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1538
ILE A1641
GLY A1595
ALA A1596
LEU A1600
 None
 0.88A 1eqhA-2pffA:
undetectable		 1eqhA-2pffA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1538
ILE A1641
GLY A1595
ALA A1596
LEU A1600
 None
 0.84A 1eqhB-2pffA:
undetectable		 1eqhB-2pffA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ALA A1033
VAL A1027
TRP A1193
 None
 0.92A 1gmkA-2pffA:
undetectable
1gmkB-2pffA:
undetectable		 1gmkA-2pffA:
1.22
1gmkB-2pffA:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ALA A1033
VAL A1027
TRP A1193
 None
 0.98A 1gmkC-2pffA:
undetectable
1gmkD-2pffA:
undetectable		 1gmkC-2pffA:
1.22
1gmkD-2pffA:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 739
LEU A 748
LEU A 765
LEU A 862
 None
 0.77A 1hk2A-2pffA:
2.3		 1hk2A-2pffA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 LEU A1522
PRO A1521
LEU A1564
ARG A1566
 None
 1.39A 1hrkB-2pffA:
2.4		 1hrkB-2pffA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.71A 1i3wE-2pffB:
undetectable		 1i3wE-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.77A 1i3wE-2pffB:
undetectable		 1i3wE-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.72A 1i3wF-2pffB:
undetectable		 1i3wF-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.76A 1i3wG-2pffB:
undetectable		 1i3wG-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.80A 1i3wG-2pffB:
undetectable		 1i3wG-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.80A 1i3wH-2pffB:
undetectable		 1i3wH-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 276
GLY B 161
LEU B 512
THR B 279
ALA B 280
 None
 1.17A 1jg2A-2pffB:
undetectable		 1jg2A-2pffB:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 ASP B  52
PHE B  48
VAL B 117
 None
 0.67A 1kijB-2pffB:
undetectable		 1kijB-2pffB:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 153
HIS B 500
ALA B 148
GLY B 150
 None
 1.01A 1l5qA-2pffB:
2.6		 1l5qA-2pffB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 153
HIS B 500
ALA B 148
GLY B 150
 None
 1.03A 1l5qB-2pffB:
2.8		 1l5qB-2pffB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 153
HIS B 500
ALA B 148
GLY B 150
 None
 1.00A 1l7xA-2pffB:
2.3		 1l7xA-2pffB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 153
HIS B 500
ALA B 148
GLY B 150
 None
 1.02A 1l7xB-2pffB:
2.7		 1l7xB-2pffB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 ALA B 247
HIS B 248
VAL B 251
 None
 0.52A 1lqtB-2pffB:
undetectable		 1lqtB-2pffB:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 ALA B 247
HIS B 248
VAL B 251
 None
 0.51A 1lquB-2pffB:
undetectable		 1lquB-2pffB:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.74A 1mnvD-2pffB:
undetectable		 1mnvD-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.72A 1mnvD-2pffB:
undetectable		 1mnvD-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 421
LEU B 370
LEU B 512
GLY B 511
 None
 0.83A 1n13D-2pffB:
undetectable
1n13E-2pffB:
undetectable		 1n13D-2pffB:
3.72
1n13E-2pffB:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 THR A1300
GLY A1330
SER A1311
ALA A1382
ALA A1587
 None
 1.25A 1nw5A-2pffA:
2.1		 1nw5A-2pffA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.75A 1ovfB-2pffB:
undetectable		 1ovfB-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.70A 1qfiA-2pffB:
undetectable		 1qfiA-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.82A 1qfiB-2pffB:
undetectable		 1qfiB-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 761
GLU A 756
THR A1371
ILE A 733
 None
 0.91A 1qvtA-2pffA:
undetectable		 1qvtA-2pffA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 732
GLY A 700
ALA A 701
VAL A 678
VAL A 703
 None
 0.89A 1t7jA-2pffA:
undetectable		 1t7jA-2pffA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.78A 1unjF-2pffB:
undetectable		 1unjF-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.72A 1unjF-2pffB:
undetectable		 1unjF-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.84A 1unjL-2pffB:
undetectable		 1unjL-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.81A 1unjL-2pffB:
undetectable		 1unjL-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.84A 1unjR-2pffB:
undetectable		 1unjR-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.79A 1unjR-2pffB:
undetectable		 1unjR-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.83A 1unjX-2pffB:
undetectable		 1unjX-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.81A 1unjX-2pffB:
undetectable		 1unjX-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.83A 1unmE-2pffB:
undetectable		 1unmE-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.84A 1unmF-2pffB:
undetectable		 1unmF-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  55
THR B  56
PRO B  54
 None
 0.82A 1unmF-2pffB:
undetectable		 1unmF-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.75A 1usqA-2pffA:
undetectable		 1usqA-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.75A 1usqB-2pffA:
undetectable		 1usqB-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.76A 1usqC-2pffA:
undetectable		 1usqC-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.75A 1usqD-2pffA:
undetectable		 1usqD-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.76A 1usqE-2pffA:
undetectable		 1usqE-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.74A 1usqF-2pffA:
undetectable		 1usqF-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1538
ILE A1641
GLY A1595
ALA A1596
LEU A1600
 None
 0.90A 2aylB-2pffA:
undetectable		 2aylB-2pffA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 443
ILE B 439
VAL B 308
GLY B 307
CYH B 310
 None
 1.26A 2bxeA-2pffB:
undetectable		 2bxeA-2pffB:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 12 THR A1581
ILE A1384
GLY A1383
GLY A1381
GLY A1248
ALA A1590
 None
 1.36A 2fk8A-2pffA:
4.9		 2fk8A-2pffA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 GLY A1595
ALA A1596
GLY A1603
ILE A1604
VAL A1639
 None
 1.04A 2fxdA-2pffA:
undetectable		 2fxdA-2pffA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 TYR A1232
TYR A1235
TYR A1715
TYR A1706
 None
 1.34A 2ha2A-2pffA:
undetectable		 2ha2A-2pffA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 ILE A1228
PRO A1231
PHE A1687
VAL A1220
 None
 1.50A 2hjhB-2pffA:
4.1		 2hjhB-2pffA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 263
LEU B 256
ILE B 457
LEU B 145
VAL B 149
 None
 1.11A 2hrcA-2pffB:
undetectable		 2hrcA-2pffB:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 LEU A1522
PRO A1521
LEU A1564
ARG A1566
 None
 1.41A 2hrcB-2pffA:
2.4		 2hrcB-2pffA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 732
GLY A 700
ALA A 701
VAL A 678
VAL A 705
VAL A 703
 None
 1.06A 2ieoB-2pffA:
undetectable		 2ieoB-2pffA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.74A 2jkjA-2pffA:
undetectable		 2jkjA-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.74A 2jkjB-2pffA:
undetectable		 2jkjB-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.74A 2jkjC-2pffA:
undetectable		 2jkjC-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.74A 2jkjE-2pffA:
undetectable		 2jkjE-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.75A 2jklA-2pffA:
undetectable		 2jklA-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.75A 2jklB-2pffA:
undetectable		 2jklB-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.75A 2jklC-2pffA:
undetectable		 2jklC-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.74A 2jklD-2pffA:
undetectable		 2jklD-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.75A 2jklE-2pffA:
undetectable		 2jklE-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 7 PRO B 426
GLY B 381
PRO B 382
THR B 317
 None
 0.85A 2jklE-2pffB:
undetectable		 2jklE-2pffB:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.74A 2jklF-2pffA:
undetectable		 2jklF-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 LEU A1522
PRO A1521
LEU A1564
ARG A1566
 None
 1.40A 2pnjB-2pffA:
2.6		 2pnjB-2pffA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 LEU A1522
PRO A1521
LEU A1564
ARG A1566
 None
 1.32A 2qd2A-2pffA:
3.1		 2qd2A-2pffA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 10 ILE B 188
LEU B 502
THR B 252
ILE B 215
GLY B 507
 None
 1.25A 2v0mA-2pffB:
undetectable		 2v0mA-2pffB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1033
ALA A1222
VAL A1021
GLY A1402
PRO A1399
 None
 0.97A 2ve3B-2pffA:
undetectable		 2ve3B-2pffA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 8 VAL B 157
GLY B 269
GLN B 495
THR B 493
 None
 0.68A 2wd9B-2pffB:
2.7		 2wd9B-2pffB:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 ASP B  51
THR B 128
GLU B 121
 None
 0.81A 2zifB-2pffB:
undetectable		 2zifB-2pffB:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 760
ILE A 749
LEU A 748
VAL A 735
ILE A 733
 None
 1.20A 3adsB-2pffA:
undetectable		 3adsB-2pffA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 7 VAL B 529
HIS B 102
THR B 252
LEU B 255
 None
 1.22A 3arrA-2pffB:
2.5		 3arrA-2pffB:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 ILE B 241
SER B 237
PRO B 239
PRO B 235
 None
 1.37A 3bjwC-2pffB:
1.1		 3bjwC-2pffB:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 GLY B 162
GLY B 505
GLY B 161
 None
 0.43A 3bogD-2pffB:
undetectable		 3bogD-2pffB:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 HIS A1542
GLY A1543
ASN A1549
PHE A1646
 None
 1.22A 3ccfA-2pffA:
5.0		 3ccfA-2pffA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 277
THR B 271
HIS B 428
LEU B 370
 None
 1.25A 3ce6D-2pffB:
undetectable		 3ce6D-2pffB:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 427
ALA B 313
ALA B 424
VAL B 423
ILE B 439
 None
 0.91A 3czhA-2pffB:
undetectable		 3czhA-2pffB:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 153
HIS B 500
ALA B 148
GLY B 150
 None
 1.03A 3dd1B-2pffB:
2.4		 3dd1B-2pffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 153
HIS B 500
ALA B 148
GLY B 150
 None
 1.05A 3ddsA-2pffB:
undetectable		 3ddsA-2pffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 153
HIS B 500
ALA B 148
GLY B 150
 None
 1.04A 3ddsB-2pffB:
1.0		 3ddsB-2pffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 153
HIS B 500
ALA B 148
GLY B 150
 None
 1.03A 3ddwA-2pffB:
undetectable		 3ddwA-2pffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 153
HIS B 500
ALA B 148
GLY B 150
 None
 1.01A 3ddwB-2pffB:
undetectable		 3ddwB-2pffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 5 ASP A1391
ARG A1017
ILE A1319
VAL A1404
THR A1528
 None
 1.46A 3eigA-2pffA:
undetectable		 3eigA-2pffA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ILE B1755
PHE B1776
PHE B1832
TYR B1702
 None
 1.19A 3elzB-2pffB:
undetectable		 3elzB-2pffB:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 TYR A1513
TYR A1529
GLU A1010
GLY A1509
VAL A1018
 None
 1.31A 3f8wB-2pffA:
undetectable		 3f8wB-2pffA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 925
LEU A 926
GLN A 898
 None
 0.84A 3g4lA-2pffA:
undetectable		 3g4lA-2pffA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 LEU A1522
PRO A1521
LEU A1564
ARG A1566
 None
 1.36A 3hcoB-2pffA:
2.4		 3hcoB-2pffA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1534
ARG A1566
ARG A1518
 None
 0.89A 3k37A-2pffA:
undetectable		 3k37A-2pffA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 994
GLU A1681
TYR A1673
TYR A1401
 None
 1.26A 3ku9B-2pffA:
3.0		 3ku9B-2pffA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 THR B 279
THR B 194
LEU B 187
LEU B 246
GLY B 242
 None
 1.37A 3n58C-2pffB:
undetectable		 3n58C-2pffB:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 VAL A1538
ILE A1641
GLY A1595
ALA A1596
LEU A1600
 None
 0.78A 3n8yA-2pffA:
undetectable		 3n8yA-2pffA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1538
ILE A1641
GLY A1595
ALA A1596
LEU A1600
 None
 0.91A 3n8zB-2pffA:
undetectable		 3n8zB-2pffA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 352
ASN B 418
LEU B 386
PHE B 416
 None
 1.30A 3nk2X-2pffB:
undetectable		 3nk2X-2pffB:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 732
GLY A 695
VAL A 678
VAL A 705
VAL A 703
 None
 1.15A 3nu9B-2pffA:
undetectable		 3nu9B-2pffA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 732
GLY A 700
ALA A 701
VAL A 678
VAL A 703
 None
 0.95A 3nu9B-2pffA:
undetectable		 3nu9B-2pffA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 GLY B 513
ASP B 503
GLN B 163
MET B 338
 None
 1.46A 3qx3A-2pffB:
0.3		 3qx3A-2pffB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 GLY B 513
ASP B 503
GLN B 163
MET B 338
 None
 1.46A 3qx3B-2pffB:
undetectable		 3qx3B-2pffB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 4 SER A1249
GLY A1645
GLU A1553
 None
 0.69A 3raeA-2pffA:
undetectable
3raeC-2pffA:
2.4		 3raeA-2pffA:
13.22
3raeC-2pffA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 770
VAL A 678
LEU A 696
ILE A 823
 None
 0.96A 3u5kB-2pffA:
undetectable		 3u5kB-2pffA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 GLY A1402
ILE A1403
VAL A1316
VAL A1312
 None
 0.78A 3ufnB-2pffA:
undetectable		 3ufnB-2pffA:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 SER A1201
ASP A1209
ASP A1334
ILE A1211
 None
 1.38A 3uj7B-2pffA:
5.1		 3uj7B-2pffA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 825
ILE A 823
GLY A 682
VAL A 735
LEU A 748
 None
 1.06A 3v8vA-2pffA:
5.8		 3v8vA-2pffA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 ASP B  52
THR B 119
LEU B 108
GLU B  53
 None
 1.43A 4a3pA-2pffB:
undetectable		 4a3pA-2pffB:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 SER A1643
GLY A1543
THR A1544
THR A1427
 None
 1.05A 4ac9C-2pffA:
2.2		 4ac9C-2pffA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1538
SER A1640
GLY A1595
ALA A1596
LEU A1600
 None
 1.01A 4coxA-2pffA:
undetectable		 4coxA-2pffA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1538
SER A1640
GLY A1595
ALA A1596
LEU A1600
 None
 1.02A 4coxD-2pffA:
undetectable		 4coxD-2pffA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 PHE A1376
ARG A1373
ALA A1548
GLY A1375
ALA A1408
 None
 1.35A 4fe1A-2pffA:
undetectable
4fe1J-2pffA:
undetectable		 4fe1A-2pffA:
15.05
4fe1J-2pffA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 HIS B 428
GLN B 275
GLY B 276
SER B 274
 None
 1.25A 4fu8A-2pffB:
undetectable		 4fu8A-2pffB:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1518
HIS A1433
TYR A1438
 None
 1.01A 4fu8A-2pffA:
undetectable		 4fu8A-2pffA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1518
HIS A1433
TYR A1438
 None
 1.13A 4fu9A-2pffA:
undetectable		 4fu9A-2pffA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR B  56
PRO B  54
THR B  55
 None
 0.81A 4hivD-2pffB:
undetectable		 4hivD-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 SER A1241
TYR A1235
PRO A1297
 None
 0.90A 4kbeB-2pffA:
6.1		 4kbeB-2pffA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 953
THR A 950
GLU A 949
GLU A 946
 None
 1.19A 4l78A-2pffA:
undetectable		 4l78A-2pffA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 CYH A1305
PHE A1343
HIS A1542
THR A1544
GLY A1645
 None
 0.81A 4ls7A-2pffA:
36.3		 4ls7A-2pffA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 12 GLY A1250
ALA A1304
PHE A1343
HIS A1542
THR A1544
PHE A1646
 None
 1.20A 4ls7A-2pffA:
36.3		 4ls7A-2pffA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 12 GLY A1250
PHE A1343
HIS A1542
THR A1544
GLY A1645
PHE A1646
 None
 0.96A 4ls7A-2pffA:
36.3		 4ls7A-2pffA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1304
CYH A1305
PHE A1343
HIS A1542
THR A1544
 None
 1.05A 4ls7A-2pffA:
36.3
4ls7B-2pffA:
36.4		 4ls7A-2pffA:
12.92
4ls7B-2pffA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 CYH A1305
PHE A1343
HIS A1542
THR A1544
GLY A1645
 None
 0.79A 4ls7A-2pffA:
36.3
4ls7B-2pffA:
36.4		 4ls7A-2pffA:
12.92
4ls7B-2pffA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 8 GLY B 505
LEU B 176
LEU B 173
GLU B 172
 None
 0.81A 4mwzB-2pffB:
undetectable		 4mwzB-2pffB:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 ASN B 165
LEU B 421
LEU B 339
ASN B 390
 None
 1.30A 4n09C-2pffB:
undetectable		 4n09C-2pffB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 922
ALA A 867
PHE A 850
 None
 0.90A 4olbA-2pffA:
3.1		 4olbA-2pffA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 LEU A1392
ARG A1502
ARG A1669
THR A1022
 None
 1.16A 4p3qA-2pffA:
undetectable		 4p3qA-2pffA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 ASN B 125
LEU B  60
GLU B  59
THR B  56
 None
 1.46A 4p6sA-2pffB:
0.0		 4p6sA-2pffB:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 679
TYR A 753
LEU A 909
ALA A 820
LEU A 862
 None
 1.01A 4rrxA-2pffA:
undetectable		 4rrxA-2pffA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 679
TYR A 753
LEU A 909
ALA A 820
LEU A 862
 None
 1.01A 4rrxB-2pffA:
undetectable		 4rrxB-2pffA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 ILE A1298
PRO A1297
HIS A1239
TYR A1706
 None
 1.30A 4s0vA-2pffA:
5.1		 4s0vA-2pffA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 GLY A1402
ASN A1601
PHE A1024
GLN A1598
GLN A1577
 None
 1.16A 4ubeA-2pffA:
6.4		 4ubeA-2pffA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 693
SER A 730
THR A 731
LEU A 732
ILE A 733
 None
 1.26A 4ubsA-2pffA:
undetectable		 4ubsA-2pffA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 TRP A1591
PHE A1214
GLU A1026
TRP A1193
 None
 1.40A 4uchA-2pffA:
undetectable
4uchB-2pffA:
undetectable		 4uchA-2pffA:
12.03
4uchB-2pffA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 922
ALA A 867
PHE A 850
 None
 0.83A 4w5nA-2pffA:
undetectable		 4w5nA-2pffA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 SER B 295
ALA B 299
VAL B 302
 None
 0.66A 4x20C-2pffB:
undetectable		 4x20C-2pffB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 5 GLY A1023
GLY A1227
GLU A1681
 None
 0.49A 4z2eA-2pffA:
undetectable
4z2eD-2pffA:
2.9		 4z2eA-2pffA:
13.71
4z2eD-2pffA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 TRP A1030
THR A1581
PRO A1029
THR A1191
 None
 1.19A 5b6iA-2pffA:
1.9		 5b6iA-2pffA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 ALA B 205
PRO B 239
GLY B 511
LEU B 232
 None
 1.00A 5eslA-2pffB:
undetectable		 5eslA-2pffB:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 ASP A1209
GLN A1271
ILE A1274
VAL A1270
ARG A1258
 None
 1.24A 5fxfB-2pffA:
0.5		 5fxfB-2pffA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ASN A1549
PHE A1576
HIS A1583
THR A1427
 None
 1.26A 5hqaA-2pffA:
undetectable		 5hqaA-2pffA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 769
PRO A 770
ILE A 749
LEU A 693
 None
 0.97A 5ieoA-2pffA:
undetectable		 5ieoA-2pffA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1200
ALA A1587
ALA A1382
VAL A1027
GLY A1248
 None
 1.06A 5igjA-2pffA:
undetectable		 5igjA-2pffA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1200
ALA A1587
ALA A1382
VAL A1027
GLY A1330
 None
 1.06A 5igjA-2pffA:
undetectable		 5igjA-2pffA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 922
ALA A 867
PHE A 850
 None
 0.91A 5js1A-2pffA:
undetectable		 5js1A-2pffA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1460
ASP A1461
ARG A1455
 None
 0.67A 5jwaA-2pffA:
4.6
5jwaH-2pffA:
4.5		 5jwaA-2pffA:
13.05
5jwaH-2pffA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 4 ASN B 418
LEU B 339
SER B 342
LEU B 421
 None
 1.34A 5kb5A-2pffB:
undetectable		 5kb5A-2pffB:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 THR A1642
PRO A1368
ARG A1373
 None
 0.62A 5nd7B-2pffA:
5.3		 5nd7B-2pffA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 VAL A1312
GLY A1595
GLN A1385
LEU A1597
 None
 0.96A 5syjB-2pffA:
undetectable		 5syjB-2pffA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 THR A1546
HIS A1542
PHE A1646
PRO A1419
 None
 1.13A 5v4vA-2pffA:
2.4		 5v4vA-2pffA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 THR A1546
HIS A1542
PHE A1646
PRO A1419
 None
 1.13A 5v4vB-2pffA:
3.0		 5v4vB-2pffA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 192
LEU B 240
ILE B 244
VAL B 184
ASP B 175
 None
 1.31A 5vlmG-2pffB:
2.2		 5vlmG-2pffB:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 261
ASP B 287
GLU B 290
PHE B 292
THR B 259
 None
 1.23A 5x6yC-2pffB:
undetectable		 5x6yC-2pffB:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 ALA A1393
LEU A1661
TYR A1662
VAL A1020
GLY A1402
 None
 1.26A 5zbdA-2pffA:
2.7		 5zbdA-2pffA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 ALA A1393
LEU A1661
TYR A1662
VAL A1020
GLY A1402
 None
 1.25A 5zbdB-2pffA:
2.1		 5zbdB-2pffA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 689
TYR A 718
VAL A 692
GLU A 691
GLY A 682
 None
 1.39A 5zniA-2pffA:
2.3		 5zniA-2pffA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 7 GLY B 162
GLY B 161
GLY B 505
GLY B 508
GLY B 507
 None
 1.02A 6ag0A-2pffB:
undetectable		 6ag0A-2pffB:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 TRP A1193
TRP A1591
PHE A1214
GLU A1026
 None
 1.35A 6auuA-2pffA:
undetectable
6auuB-2pffA:
undetectable		 6auuA-2pffA:
4.12
6auuB-2pffA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 188
PHE B 292
ILE B 236
ALA B 299
 None
 0.87A 6b5vA-2pffB:
undetectable
6b5vC-2pffB:
undetectable		 6b5vA-2pffB:
2.98
6b5vC-2pffB:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 7 ALA B 299
ILE B 188
PHE B 292
ILE B 236
 None
 0.87A 6b5vA-2pffB:
undetectable
6b5vB-2pffB:
undetectable		 6b5vA-2pffB:
2.98
6b5vB-2pffB:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 188
PHE B 292
ILE B 236
ALA B 299
 None
 0.87A 6b5vC-2pffB:
undetectable
6b5vD-2pffB:
undetectable		 6b5vC-2pffB:
2.98
6b5vD-2pffB:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 7 ALA B 299
ILE B 188
PHE B 292
ILE B 236
 None
 0.88A 6b5vB-2pffB:
undetectable
6b5vD-2pffB:
undetectable		 6b5vB-2pffB:
2.98
6b5vD-2pffB:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 GLU B 172
HIS B 248
LEU B 255
VAL B 251
 None
 1.02A 6bc9A-2pffB:
undetectable		 6bc9A-2pffB:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 732
GLY A 700
ALA A 701
VAL A 678
VAL A 705
VAL A 703
 None
 1.10A 6dh0A-2pffA:
undetectable		 6dh0A-2pffA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2pff FATTY ACID SYNTHASE
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 ALA B 424
PHE B 427
GLN B 275
 None
 0.66A 6eceA-2pffB:
3.4		 6eceA-2pffB:
7.07