SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		5 / 12 GLY A 666
ASN A 552
SER A 573
PHE A 657
VAL A 658
 None
 1.22A 1ffyA-2pfiA:
undetectable		 1ffyA-2pfiA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		5 / 12 GLY A 666
ASN A 552
SER A 573
PHE A 657
VAL A 658
 None
 1.28A 1qu3A-2pfiA:
undetectable		 1qu3A-2pfiA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		4 / 8 LYS A 569
VAL A 570
TYR A 579
LEU A 558
 None
 1.02A 1z2bB-2pfiA:
undetectable		 1z2bB-2pfiA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		4 / 8 VAL A 594
LEU A 558
ASP A 620
ILE A 621
 None
 0.89A 4lzrA-2pfiA:
undetectable		 4lzrA-2pfiA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		5 / 11 PHE A 550
ALA A 676
VAL A 668
LEU A 653
LEU A 635
 None
CL  A 504 ( 4.2A)
None
None
None
 1.17A 4zmeA-2pfiA:
undetectable		 4zmeA-2pfiA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		5 / 10 PHE A 550
ALA A 676
VAL A 668
LEU A 653
LEU A 635
 None
CL  A 504 ( 4.2A)
None
None
None
 1.18A 4zmeB-2pfiA:
undetectable		 4zmeB-2pfiA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		3 / 3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.37A 5i1nC-2pfiA:
undetectable		 5i1nC-2pfiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		3 / 3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.23A 5i1nB-2pfiA:
undetectable		 5i1nB-2pfiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		3 / 3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.20A 5i1oC-2pfiA:
undetectable		 5i1oC-2pfiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		3 / 3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.26A 5i1oA-2pfiA:
undetectable		 5i1oA-2pfiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		3 / 3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.26A 5i1pA-2pfiA:
undetectable		 5i1pA-2pfiA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens) 		3 / 3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.18A 5i1pD-2pfiA:
undetectable		 5i1pD-2pfiA:
14.50