SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 10 TYR A 224
LEU A 322
ALA A 318
ILE A 286
ALA A 222
 None
 1.19A 1xp0A-2pfmA:
undetectable		 1xp0A-2pfmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 12 THR A  95
VAL A  70
ASP A  69
SER A 308
HIS A 307
 None
 1.10A 1xvaA-2pfmA:
undetectable		 1xvaA-2pfmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		4 / 7 ALA A 239
ARG A 243
TYR A   5
TYR A 324
 None
 1.09A 2ajvH-2pfmA:
undetectable
2ajvL-2pfmA:
undetectable		 2ajvH-2pfmA:
18.64
2ajvL-2pfmA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 11 THR A 176
LEU A 322
SER A 234
ILE A 286
ALA A 222
 None
 1.17A 2zbzA-2pfmA:
undetectable		 2zbzA-2pfmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 11 LEU A 228
ALA A 318
ASN A 323
MET A  10
ALA A 111
 None
 1.19A 3e22B-2pfmA:
undetectable		 3e22B-2pfmA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 11 LEU A 228
ALA A 318
ASN A 323
MET A  10
ALA A 111
 None
 1.19A 3e22D-2pfmA:
undetectable		 3e22D-2pfmA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 9 ALA A 321
ILE A   2
GLY A  11
ILE A  13
LEU A 315
 None
 1.02A 3u7sB-2pfmA:
undetectable		 3u7sB-2pfmA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		4 / 8 ASN A 327
PHE A 329
VAL A 333
ILE A 125
 None
 0.96A 4eyzA-2pfmA:
undetectable		 4eyzA-2pfmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		4 / 8 GLU A  27
GLU A 197
GLY A 184
SER A 183
 None
 0.82A 4f93B-2pfmA:
undetectable		 4f93B-2pfmA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		3 / 3 ARG A 178
GLU A 207
ASN A 175
 None
 0.87A 4imaD-2pfmA:
undetectable		 4imaD-2pfmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		3 / 3 ARG A 178
GLU A 207
ASN A 175
 None
 0.87A 4ip7D-2pfmA:
undetectable		 4ip7D-2pfmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 11 VAL A 253
THR A 136
LEU A 156
VAL A 338
THR A 250
 None
 1.26A 4kyaA-2pfmA:
undetectable		 4kyaA-2pfmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 11 VAL A 253
THR A 136
LEU A 156
VAL A 338
THR A 250
 None
 1.26A 4kyaE-2pfmA:
undetectable		 4kyaE-2pfmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 11 VAL A 253
THR A 136
LEU A 156
VAL A 338
THR A 250
 None
 1.24A 4kyaG-2pfmA:
undetectable		 4kyaG-2pfmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		4 / 6 ASN A 346
GLU A 341
TYR A 339
GLU A 252
 None
 1.36A 4mi4A-2pfmA:
undetectable		 4mi4A-2pfmA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 9 ILE A 114
GLU A   9
LEU A 282
LEU A 326
ILE A 235
 None
 1.25A 4r38C-2pfmA:
undetectable		 4r38C-2pfmA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		4 / 7 ASN A 346
GLU A 341
TYR A 339
GLU A 252
 None
 1.36A 4r87I-2pfmA:
undetectable		 4r87I-2pfmA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		4 / 8 GLY A 330
TYR A   5
ALA A 321
PHE A 122
 None
 0.76A 5albL-2pfmA:
undetectable		 5albL-2pfmA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		4 / 4 THR A 250
GLU A 252
THR A 350
HIS A 146
 None
 1.41A 5f9zA-2pfmA:
0.0		 5f9zA-2pfmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		4 / 4 THR A 250
GLU A 252
THR A 350
HIS A 146
 None
 1.40A 5f9zB-2pfmA:
0.0		 5f9zB-2pfmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		5 / 12 VAL A  45
LEU A 204
THR A 102
GLY A  93
LEU A  94
 None
 1.35A 5m50E-2pfmA:
undetectable		 5m50E-2pfmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2pfm ADENYLOSUCCINATE
LYASE
(Bacillus
anthracis) 		4 / 5 ASN A 121
ASP A 118
ASN A 323
ASN A 331
 None
 1.43A 5vooA-2pfmA:
undetectable		 5vooA-2pfmA:
21.91