SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 6 GLN A 130
ASP A 122
VAL A  71
HIS A 107
 None
None
None
COA  A 401 (-4.5A)
 1.35A 1ekjG-2pfrA:
undetectable
1ekjH-2pfrA:
undetectable		 1ekjG-2pfrA:
23.63
1ekjH-2pfrA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 ILE A   3
ALA A  78
LEU A  75
LEU A  24
ILE A  82
 None
 0.93A 1g5yB-2pfrA:
undetectable		 1g5yB-2pfrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		3 / 3 TRP A  67
HIS A  43
MET A  42
 None
 1.26A 1l5qB-2pfrA:
undetectable		 1l5qB-2pfrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		3 / 3 THR A 207
GLU A  49
ASP A  57
 None
 0.83A 1nt2A-2pfrA:
undetectable		 1nt2A-2pfrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 ILE A  82
ILE A   3
PHE A   7
LEU A  74
GLN A  31
 None
 0.95A 1qhyA-2pfrA:
undetectable		 1qhyA-2pfrA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.20A 1rg9A-2pfrA:
undetectable		 1rg9A-2pfrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.19A 1rg9B-2pfrA:
undetectable		 1rg9B-2pfrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.20A 1rg9C-2pfrA:
undetectable		 1rg9C-2pfrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.19A 1rg9D-2pfrA:
undetectable		 1rg9D-2pfrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.22A 2obvA-2pfrA:
undetectable		 2obvA-2pfrA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.22A 2p02A-2pfrA:
undetectable		 2p02A-2pfrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 7 LEU A  69
ARG A 197
SER A 215
GLY A 104
 None
None
COA  A 401 (-4.0A)
COA  A 401 (-4.0A)
 0.99A 3hcrB-2pfrA:
undetectable		 3hcrB-2pfrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 7 ILE A  32
GLN A 130
GLY A 124
VAL A  71
 None
 1.00A 4a3uB-2pfrA:
undetectable		 4a3uB-2pfrA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		3 / 3 ARG A  62
GLU A  49
ARG A  64
 UNX  A1004 (-4.2A)
None
UNX  A1004 (-4.0A)
 0.81A 4mwvA-2pfrA:
undetectable		 4mwvA-2pfrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 ILE A 170
LEU A 181
VAL A 235
GLY A 236
LEU A 252
 None
 1.04A 5ienA-2pfrA:
undetectable		 5ienA-2pfrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 MET A 131
GLN A 133
GLU A 136
LEU A 135
ILE A 120
 None
 1.18A 5vlmB-2pfrA:
undetectable		 5vlmB-2pfrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 ILE A 189
LEU A 288
LEU A 161
PHE A  93
LEU A 135
 None
UNX  A1009 ( 4.2A)
None
COA  A 401 ( 3.8A)
None
 1.02A 6b54A-2pfrA:
undetectable		 6b54A-2pfrA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		5 / 12 LEU A 135
SER A 127
PHE A 244
VAL A 231
LEU A 109
 None
UNX  A1009 ( 4.0A)
None
None
None
 1.12A 6djzB-2pfrA:
undetectable		 6djzB-2pfrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 8 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.21A 6fbnB-2pfrA:
undetectable		 6fbnB-2pfrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens) 		4 / 5 ARG A 197
MET A  88
THR A  87
LEU A 110
 None
UNX  A1027 (-4.5A)
None
None
 1.35A 6nknW-2pfrA:
undetectable		 6nknW-2pfrA:
14.34