SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		3 / 3 ALA A 592
VAL A 590
TRP A 591
 None
 0.90A 1bdwA-2pftA:
undetectable
1bdwB-2pftA:
undetectable		 1bdwA-2pftA:
2.57
1bdwB-2pftA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		5 / 8 ALA A 492
ILE A 530
PRO A 594
ILE A 593
ILE A 493
 None
 1.29A 1hshD-2pftA:
undetectable		 1hshD-2pftA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 6 HIS A 342
PHE A 344
ASP A 396
ASP A 399
 None
 1.11A 1ilqA-2pftA:
undetectable
1ilqC-2pftA:
undetectable		 1ilqA-2pftA:
10.38
1ilqC-2pftA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		3 / 3 ASP A  96
LYS A  99
ARG A 102
 None
 1.11A 1ra8A-2pftA:
undetectable		 1ra8A-2pftA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 7 TYR A 282
THR A 437
GLU A 387
VAL A 286
 None
 1.15A 1tv8A-2pftA:
undetectable		 1tv8A-2pftA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		5 / 11 GLY A 390
GLU A 395
PHE A 351
PHE A 344
PHE A 427
 None
 1.40A 1w76A-2pftA:
undetectable		 1w76A-2pftA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 8 TYR A 282
THR A 437
GLU A 387
VAL A 286
 None
 1.17A 2fb2A-2pftA:
undetectable		 2fb2A-2pftA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 7 TYR A 282
THR A 437
GLU A 387
VAL A 286
 None
 1.22A 2fb2B-2pftA:
undetectable		 2fb2B-2pftA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		5 / 12 ALA A 440
TYR A 466
VAL A 470
LEU A 394
LEU A 432
 None
 1.28A 2rctA-2pftA:
undetectable		 2rctA-2pftA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 6 ARG A 637
ASP A 643
ILE A 645
GLN A 604
 None
 1.26A 2ya7C-2pftA:
undetectable		 2ya7C-2pftA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 5 ILE A 174
THR A 360
PHE A 364
PHE A 289
 None
 1.35A 3em0A-2pftA:
undetectable		 3em0A-2pftA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 6 LEU A 292
SER A 295
LEU A 299
LEU A 227
 None
 0.73A 3f33A-2pftA:
2.5		 3f33A-2pftA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		5 / 11 LEU A 188
GLU A 296
HIS A 190
LEU A 170
SER A 230
 None
 1.24A 3o94A-2pftA:
undetectable		 3o94A-2pftA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		5 / 11 LEU A 188
GLU A 296
HIS A 190
LEU A 170
SER A 230
 None
 1.28A 3o94B-2pftA:
undetectable		 3o94B-2pftA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		5 / 11 LEU A 188
GLU A 296
HIS A 190
LEU A 170
SER A 230
 None
 1.28A 3o94C-2pftA:
undetectable		 3o94C-2pftA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		5 / 11 LEU A 188
GLU A 296
HIS A 190
LEU A 170
SER A 230
 None
 1.28A 3o94D-2pftA:
undetectable		 3o94D-2pftA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		5 / 12 LYS A 469
LEU A 471
ASN A 473
ALA A 424
ILE A 425
 None
 1.17A 3ut5D-2pftA:
undetectable		 3ut5D-2pftA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		5 / 12 ALA A 440
TYR A 466
VAL A 470
LEU A 394
LEU A 432
 None
 1.31A 4qynA-2pftA:
undetectable		 4qynA-2pftA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 6 HIS A 356
LEU A 357
CYH A 285
LEU A 324
 None
 1.18A 5hrqD-2pftA:
undetectable
5hrqG-2pftA:
undetectable
5hrqH-2pftA:
undetectable		 5hrqD-2pftA:
4.38
5hrqG-2pftA:
3.29
5hrqH-2pftA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 6 HIS A 356
LEU A 357
CYH A 285
LEU A 324
 None
 1.20A 5hrqB-2pftA:
undetectable
5hrqI-2pftA:
undetectable
5hrqJ-2pftA:
undetectable		 5hrqB-2pftA:
4.38
5hrqI-2pftA:
3.29
5hrqJ-2pftA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2pft EXOCYTOSIS PROTEIN
(Mus
musculus) 		4 / 6 ILE A 100
GLY A 114
TYR A 112
GLU A 111
 None
 1.08A 6gqiA-2pftA:
undetectable		 6gqiA-2pftA:
20.85