SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 202
GLU A 253
TYR A 174
TYR A 261
 None
 1.40A 1qvuA-2pfvA:
1.9		 1qvuA-2pfvA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 352
ILE A 353
THR A 372
 None
 0.64A 1rg7A-2pfvA:
undetectable		 1rg7A-2pfvA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 441
VAL A 440
TYR A 511
LEU A 379
ASP A 374
 None
 1.42A 2iyfB-2pfvA:
undetectable		 2iyfB-2pfvA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 472
GLY A 473
LEU A 477
LEU A 480
 None
 0.86A 2vctA-2pfvA:
4.9		 2vctA-2pfvA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 472
GLY A 473
LEU A 477
LEU A 480
 None
 0.85A 2vctB-2pfvA:
4.9		 2vctB-2pfvA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 472
GLY A 473
LEU A 477
LEU A 480
 None
 0.93A 2vctC-2pfvA:
5.1		 2vctC-2pfvA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 503
GLY A 498
GLU A 499
SER A 490
 None
 1.43A 2xctS-2pfvA:
undetectable
2xctU-2pfvA:
undetectable		 2xctS-2pfvA:
23.87
2xctU-2pfvA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 8 THR A 341
SER A 305
TYR A 385
CYH A 389
 None
 1.17A 2xz5A-2pfvA:
undetectable
2xz5C-2pfvA:
undetectable		 2xz5A-2pfvA:
17.35
2xz5C-2pfvA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 113
ILE A 114
LEU A 134
GLU A  80
 None
 1.08A 2ya7A-2pfvA:
undetectable		 2ya7A-2pfvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 268
LEU A 260
ASP A 258
SER A 183
 None
 1.18A 3dzgA-2pfvA:
undetectable		 3dzgA-2pfvA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 472
GLN A 470
ILE A 362
LEU A 577
 None
 1.15A 3dzyD-2pfvA:
undetectable		 3dzyD-2pfvA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 210
GLY A 248
TYR A 173
LEU A 272
 None
 0.74A 3elzA-2pfvA:
undetectable		 3elzA-2pfvA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 521
ASN A 525
SER A 464
 None
 0.78A 3lslA-2pfvA:
undetectable
3lslD-2pfvA:
undetectable		 3lslA-2pfvA:
18.82
3lslD-2pfvA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 357
ALA A 356
LYS A 445
 None
 0.95A 3runA-2pfvA:
undetectable		 3runA-2pfvA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		5 / 11 THR A 563
LEU A 618
THR A 615
LEU A 577
VAL A 575
 None
 1.38A 3tbgA-2pfvA:
2.3		 3tbgA-2pfvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		3 / 3 THR A  67
ASN A  69
GLU A  80
 None
 0.69A 3v4tA-2pfvA:
1.1
3v4tC-2pfvA:
undetectable		 3v4tA-2pfvA:
21.32
3v4tC-2pfvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 260
TYR A 174
LEU A 202
TYR A 261
 None
 0.97A 3v81A-2pfvA:
undetectable		 3v81A-2pfvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 206
LEU A 153
ALA A 181
ILE A 152
 None
 0.85A 3wsjB-2pfvA:
undetectable		 3wsjB-2pfvA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 352
ALA A 371
PRO A 456
ILE A 353
THR A 372
 None
 1.20A 4g8zX-2pfvA:
undetectable		 4g8zX-2pfvA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 356
ILE A 431
LEU A 507
LEU A 504
GLY A 500
 None
 1.01A 4l9qB-2pfvA:
2.4		 4l9qB-2pfvA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 260
TYR A 174
LEU A 202
TYR A 261
 None
 0.94A 4puoC-2pfvA:
undetectable		 4puoC-2pfvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 330
THR A 334
VAL A 309
SER A 311
 None
 1.04A 4qknA-2pfvA:
4.5		 4qknA-2pfvA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 402
TYR A 411
ASN A 441
ILE A 353
 None
 1.15A 4y03B-2pfvA:
undetectable		 4y03B-2pfvA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 462
LYS A 469
VAL A 516
THR A 523
ALA A 524
 None
 1.31A 4yhaG-2pfvA:
undetectable		 4yhaG-2pfvA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		3 / 3 SER A  73
ALA A  72
THR A  67
 None
 0.57A 5n0xB-2pfvA:
undetectable		 5n0xB-2pfvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 186
ILE A 198
GLY A 195
LEU A  97
LEU A 145
 None
 1.24A 5nfjC-2pfvA:
undetectable		 5nfjC-2pfvA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 352
ALA A 371
ILE A 353
THR A 372
 None
 0.83A 5uihA-2pfvA:
undetectable		 5uihA-2pfvA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2pfv EXOCYST COMPLEX
COMPONENT EXO70
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 195
SER A 267
TYR A 261
GLN A 199
 None
 1.24A 6ji6A-2pfvA:
2.9		 6ji6A-2pfvA:
19.59