SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pfy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 12 LEU A 181
ALA A 204
GLY A 277
MET A 280
LEU A 269
 None
 1.31A 1brpA-2pfyA:
undetectable		 1brpA-2pfyA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 7 LEU A 137
ALA A 158
PHE A 142
VAL A 159
 None
 0.84A 1epbA-2pfyA:
undetectable		 1epbA-2pfyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 8 LEU A 137
ALA A 158
PHE A 142
VAL A 159
 None
 0.81A 1epbB-2pfyA:
undetectable		 1epbB-2pfyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 12 LEU A 137
ALA A 179
VAL A 196
VAL A 131
LEU A 265
 None
 1.10A 2g78A-2pfyA:
undetectable		 2g78A-2pfyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 8 PHE A 172
TYR A 195
THR A 182
ILE A 177
 None
None
PCA  A 302 (-3.5A)
None
 0.97A 2qbmA-2pfyA:
undetectable		 2qbmA-2pfyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 12 ILE A  62
GLN A  61
ASN A 214
GLY A  54
LEU A  46
 None
 1.26A 2zw9A-2pfyA:
undetectable		 2zw9A-2pfyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 12 PHE A  23
GLU A  26
GLN A  22
SER A 118
TYR A 116
 None
 1.45A 3apwB-2pfyA:
undetectable		 3apwB-2pfyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 11 THR A  99
LEU A 295
LEU A 296
ASP A  80
VAL A  82
 None
 1.23A 3lxiB-2pfyA:
undetectable		 3lxiB-2pfyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 6 THR A 149
GLN A 123
TYR A 145
SER A  81
 None
PCA  A 302 (-3.0A)
PCA  A 302 (-3.9A)
None
 0.93A 3peoG-2pfyA:
undetectable		 3peoG-2pfyA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 7 PRO A  83
LEU A 269
ILE A 276
MET A 280
 None
 0.94A 3u5jA-2pfyA:
undetectable		 3u5jA-2pfyA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 10 THR A  99
LEU A 295
LEU A 296
ASP A  80
VAL A  82
 None
 1.24A 4c9nB-2pfyA:
undetectable		 4c9nB-2pfyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 10 THR A  99
LEU A 295
LEU A 296
ASP A  80
VAL A  82
 None
 1.27A 4c9pB-2pfyA:
undetectable		 4c9pB-2pfyA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 7 VAL A 196
SER A 190
TYR A 195
LEU A 255
 None
 1.21A 4hxyB-2pfyA:
undetectable		 4hxyB-2pfyA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 2pfy PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 12 MET A 156
ALA A 133
LEU A 273
TYR A 199
ASP A 201
 None
 1.47A 5vlmD-2pfyA:
0.6		 5vlmD-2pfyA:
21.26