SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 7 LEU A 273
VAL A 276
GLY A 277
VAL A 148
 None
 0.91A 1t88A-2pfzA:
undetectable		 1t88A-2pfzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 9 THR A 202
LEU A 269
VAL A 134
GLY A 272
ILE A 152
 None
 1.15A 2a1oB-2pfzA:
undetectable		 2a1oB-2pfzA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 12 PHE A  23
VAL A  55
ALA A 232
ALA A 228
LEU A 221
 None
 1.34A 2x2nC-2pfzA:
undetectable		 2x2nC-2pfzA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		6 / 12 LEU A 212
LEU A 107
LEU A 103
ALA A 210
ASN A 209
LEU A  79
 None
 1.43A 3r9cA-2pfzA:
undetectable		 3r9cA-2pfzA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 9 PHE A  23
LEU A 229
THR A 225
LEU A   6
ILE A  37
 None
 1.17A 3tbgD-2pfzA:
undetectable		 3tbgD-2pfzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 10 TYR A  96
VAL A  76
TYR A 116
LEU A 115
LEU A 212
 None
 1.41A 4jq4A-2pfzA:
undetectable		 4jq4A-2pfzA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 4 LYS A 208
ASN A 248
ASP A 201
ASP A  80
 None
 1.49A 4o1eB-2pfzA:
0.0		 4o1eB-2pfzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 5 PHE A  23
ILE A  62
GLY A 233
ILE A  37
 None
 0.81A 5dzkB-2pfzA:
undetectable
5dzkI-2pfzA:
undetectable
5dzkW-2pfzA:
undetectable		 5dzkB-2pfzA:
20.82
5dzkI-2pfzA:
21.04
5dzkW-2pfzA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 5 PHE A  23
ILE A  62
GLY A 233
ILE A  37
 None
 0.83A 5dzkd-2pfzA:
undetectable
5dzkk-2pfzA:
undetectable
5dzky-2pfzA:
undetectable		 5dzkd-2pfzA:
20.82
5dzkk-2pfzA:
21.04
5dzky-2pfzA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 12 LEU A 115
PHE A  23
ILE A  62
THR A   2
GLY A  32
 None
 1.08A 5veuB-2pfzA:
undetectable		 5veuB-2pfzA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		5 / 12 MET A 137
VAL A 134
SER A 179
ILE A 125
THR A 202
 None
 1.32A 5w8aA-2pfzA:
undetectable		 5w8aA-2pfzA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2pfz PUTATIVE EXPORTED
PROTEIN
(Bordetella
pertussis) 		4 / 4 GLY A  81
LEU A  82
VAL A 148
GLU A  78
 None
 1.07A 5yw0A-2pfzA:
undetectable		 5yw0A-2pfzA:
21.43