SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 8 LEU A 125
ALA A 417
GLY A 116
PHE A 124
 None
 0.79A 1d4sB-2pg8A:
undetectable		 1d4sB-2pg8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		3 / 3 ASP A 195
ASP A 202
ASP A 249
 None
 0.64A 1eizA-2pg8A:
undetectable		 1eizA-2pg8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		3 / 3 ASP A 195
ASP A 202
ASP A 249
 None
 0.62A 1ej0A-2pg8A:
undetectable		 1ej0A-2pg8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 8 LEU A  82
VAL A 128
LEU A 129
ALA A 413
 None
 0.83A 1fiqC-2pg8A:
undetectable		 1fiqC-2pg8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		6 / 12 GLY A 327
ALA A 329
VAL A 345
GLY A 295
ALA A 320
ILE A 346
 YE1  A 997 (-3.4A)
None
None
YE1  A 997 (-3.5A)
None
None
 1.36A 1rl8A-2pg8A:
undetectable		 1rl8A-2pg8A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		3 / 3 PRO A 147
ASP A 202
ASP A 195
 None
 0.74A 1sqfA-2pg8A:
undetectable		 1sqfA-2pg8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 8 SER A 379
LEU A 372
LEU A 262
PHE A 231
 None
 0.94A 1wrlC-2pg8A:
undetectable
1wrlD-2pg8A:
undetectable		 1wrlC-2pg8A:
12.29
1wrlD-2pg8A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 9 GLU A 198
LEU A 129
LEU A 138
ARG A  81
ALA A  83
 None
 1.31A 2bxcB-2pg8A:
undetectable		 2bxcB-2pg8A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 8 SER A 342
PHE A 405
ALA A 407
PHE A 412
 None
 0.89A 3aodA-2pg8A:
undetectable		 3aodA-2pg8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		3 / 3 ASP A 195
ASP A 202
ASP A 249
 None
 0.68A 3douA-2pg8A:
undetectable		 3douA-2pg8A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		3 / 3 ASN A 391
ASN A 396
GLU A 282
 None
 0.90A 3kpdC-2pg8A:
undetectable		 3kpdC-2pg8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		3 / 3 ASN A 391
ASN A 396
GLU A 282
 None
 0.88A 3kpdB-2pg8A:
undetectable		 3kpdB-2pg8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 ARG A 332
ILE A 259
GLY A 327
ALA A 328
LEU A 331
 None
None
YE1  A 997 (-3.4A)
None
None
 1.24A 3n8xA-2pg8A:
undetectable		 3n8xA-2pg8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 PHE A 412
ILE A 324
ALA A 319
ILE A 294
ALA A 233
 None
OXY  A   3 (-3.9A)
OXY  A   3 (-3.2A)
YE1  A 997 ( 4.4A)
YE1  A 997 (-3.9A)
 0.94A 3nxuA-2pg8A:
undetectable		 3nxuA-2pg8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 PHE A 412
ILE A 324
ALA A 319
ILE A 294
ALA A 233
 None
OXY  A   3 (-3.9A)
OXY  A   3 (-3.2A)
YE1  A 997 ( 4.4A)
YE1  A 997 (-3.9A)
 0.92A 3nxuB-2pg8A:
undetectable		 3nxuB-2pg8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 8 ALA A  65
VAL A  68
LEU A  72
LEU A 125
 None
 0.65A 3roxA-2pg8A:
undetectable		 3roxA-2pg8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 9 LEU A 240
GLY A 327
ILE A 325
ILE A 245
ILE A 235
 None
YE1  A 997 (-3.4A)
None
None
YE1  A 997 (-3.3A)
 1.12A 3s56B-2pg8A:
undetectable		 3s56B-2pg8A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 8 ILE A 245
ASP A 190
GLN A 299
GLY A 295
 None
None
YE1  A 997 (-3.6A)
YE1  A 997 (-3.5A)
 0.83A 4ac9C-2pg8A:
2.0		 4ac9C-2pg8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 GLU A 189
MET A 197
ASP A 190
ASP A 184
SER A 232
 YE1  A 997 (-2.3A)
None
None
None
None
 1.28A 4djeB-2pg8A:
undetectable		 4djeB-2pg8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		6 / 12 PHE A 304
LEU A 372
ALA A 354
ALA A 293
GLY A 297
ALA A 288
 None
 1.48A 4enhA-2pg8A:
undetectable		 4enhA-2pg8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 8 PHE A 231
VAL A 167
SER A 232
GLY A 217
ALA A 200
 None
 0.91A 4m48A-2pg8A:
undetectable		 4m48A-2pg8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 ALA A 329
ILE A 235
GLY A 297
ALA A 298
ILE A 346
 None
YE1  A 997 (-3.3A)
None
None
None
 0.86A 4nkxA-2pg8A:
undetectable		 4nkxA-2pg8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 ALA A 329
ILE A 235
GLY A 297
ALA A 298
ILE A 346
 None
YE1  A 997 (-3.3A)
None
None
None
 0.80A 4nkxC-2pg8A:
undetectable		 4nkxC-2pg8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 ALA A 329
ILE A 235
GLY A 297
ALA A 298
ILE A 346
 None
YE1  A 997 (-3.3A)
None
None
None
 0.81A 4nkxD-2pg8A:
undetectable		 4nkxD-2pg8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 ILE A  46
ALA A  21
SER A  24
LEU A  28
LEU A  29
 None
 0.96A 4o1zA-2pg8A:
undetectable		 4o1zA-2pg8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		3 / 3 ALA A 287
GLN A 299
GLY A 327
 None
YE1  A 997 (-3.6A)
YE1  A 997 (-3.4A)
 0.62A 4odoC-2pg8A:
undetectable		 4odoC-2pg8A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 5 ASP A 202
LEU A 205
ARG A 392
THR A 146
 None
 1.26A 4p3qA-2pg8A:
undetectable		 4p3qA-2pg8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 6 ALA A 329
ILE A 235
GLY A 296
ILE A 346
 None
YE1  A 997 (-3.3A)
YE1  A 997 (-3.6A)
None
 0.74A 4r21A-2pg8A:
undetectable		 4r21A-2pg8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 7 ARG A 335
LEU A 302
ALA A 329
ILE A 259
LEU A 300
 None
 1.45A 5te8C-2pg8A:
undetectable		 5te8C-2pg8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		3 / 3 TYR A  69
HIS A  79
MET A 142
 None
 1.13A 6af6A-2pg8A:
2.4		 6af6A-2pg8A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 6 PHE A 336
ARG A 335
ASN A 396
ASP A 399
 None
 1.42A 6dhbA-2pg8A:
undetectable		 6dhbA-2pg8A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		4 / 5 GLY A 174
ASP A 173
ARG A 171
ARG A 177
 None
 1.35A 6dwdB-2pg8A:
undetectable
6dwdD-2pg8A:
undetectable		 6dwdB-2pg8A:
21.39
6dwdD-2pg8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		3 / 3 LEU A 215
GLY A 213
PHE A 156
 None
 0.65A 6exiC-2pg8A:
undetectable		 6exiC-2pg8A:
10.41