SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		5 / 12 PHE A  61
PRO A 112
GLY A 166
ILE A 134
LEU A 149
 None
 1.35A 3iv6C-2pgcA:
undetectable		 3iv6C-2pgcA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		5 / 12 HIS A  52
VAL A  14
TYR A  93
ILE A  47
GLY A  45
 None
 1.27A 3kk6B-2pgcA:
undetectable		 3kk6B-2pgcA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		5 / 12 LEU A 101
GLY A 152
ILE A 134
LEU A 149
THR A 103
 None
 1.17A 4o5fA-2pgcA:
undetectable
4o5fB-2pgcA:
undetectable		 4o5fA-2pgcA:
19.92
4o5fB-2pgcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		5 / 12 LEU A 149
THR A 103
LEU A 101
GLY A 152
ILE A 134
 None
 1.16A 4o5fA-2pgcA:
undetectable
4o5fB-2pgcA:
undetectable		 4o5fA-2pgcA:
19.92
4o5fB-2pgcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		5 / 12 GLY A  54
ILE A 203
ASN A 201
GLY A  45
SER A  13
 None
 1.27A 4obwC-2pgcA:
undetectable		 4obwC-2pgcA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		5 / 12 GLY A  88
ILE A  92
ASN A  91
ASP A  86
GLN A  75
 None
 1.23A 4rtpA-2pgcA:
undetectable		 4rtpA-2pgcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		5 / 12 LEU A 101
GLY A 152
ILE A 134
LEU A 149
THR A 103
 None
 1.14A 5b8hA-2pgcA:
undetectable
5b8hB-2pgcA:
undetectable		 5b8hA-2pgcA:
21.56
5b8hB-2pgcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		5 / 12 LEU A 149
THR A 103
LEU A 101
GLY A 152
ILE A 134
 None
 1.14A 5b8hA-2pgcA:
undetectable
5b8hB-2pgcA:
undetectable		 5b8hA-2pgcA:
21.56
5b8hB-2pgcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		4 / 6 HIS A 185
LEU A 182
CYH A 133
LEU A 191
 None
 1.27A 5hrqD-2pgcA:
undetectable
5hrqG-2pgcA:
undetectable
5hrqH-2pgcA:
undetectable		 5hrqD-2pgcA:
8.38
5hrqG-2pgcA:
7.04
5hrqH-2pgcA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		3 / 3 SER A 171
TYR A 169
TYR A 114
 None
 0.85A 5lakA-2pgcA:
0.5
5lakI-2pgcA:
undetectable		 5lakA-2pgcA:
20.48
5lakI-2pgcA:
1.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2pgc UNCHARACTERIZED
PROTEIN
(uncultured
marine
organism) 		3 / 3 SER A 171
TYR A 169
TYR A 114
 None
 0.86A 5lakC-2pgcA:
undetectable
5lakJ-2pgcA:
undetectable		 5lakC-2pgcA:
20.48
5lakJ-2pgcA:
1.85