SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pge'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2pge MENC
(Desulfotalea
psychrophila) 		4 / 6 ARG A 151
GLY A 363
ASP A 362
TYR A 178
 None
 1.35A 1kf6M-2pgeA:
undetectable
1kf6N-2pgeA:
undetectable		 1kf6M-2pgeA:
20.75
1kf6N-2pgeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2pge MENC
(Desulfotalea
psychrophila) 		4 / 8 SER A 258
ASP A 214
MET A 251
LEU A 228
 None
 1.09A 1lhvA-2pgeA:
undetectable		 1lhvA-2pgeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 ILE A 103
GLY A 296
ALA A 301
VAL A 112
SER A 113
 None
 1.10A 1sg9C-2pgeA:
undetectable		 1sg9C-2pgeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2pge MENC
(Desulfotalea
psychrophila) 		4 / 4 LEU A  69
SER A 109
LEU A  37
LEU A 125
 None
 1.12A 1yajA-2pgeA:
undetectable		 1yajA-2pgeA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2pge MENC
(Desulfotalea
psychrophila) 		3 / 3 TRP A 159
LEU A 181
LYS A 173
 None
 1.26A 1yajK-2pgeA:
undetectable		 1yajK-2pgeA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 LEU A  81
LEU A  85
GLY A  44
ALA A 128
ALA A 124
 None
 0.92A 2bm9C-2pgeA:
undetectable		 2bm9C-2pgeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 LEU A  81
LEU A  85
GLY A  44
ALA A 128
ALA A 124
 None
 0.97A 2bm9D-2pgeA:
undetectable		 2bm9D-2pgeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 LEU A  81
LEU A  85
GLY A  44
ALA A 128
ALA A 124
 None
 0.99A 2bm9F-2pgeA:
undetectable		 2bm9F-2pgeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 LEU A  81
LEU A  85
GLY A  44
ALA A 128
ALA A 124
 None
 1.06A 2br4C-2pgeA:
undetectable		 2br4C-2pgeA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 LEU A  81
LEU A  85
GLY A  44
ALA A 128
ALA A 124
 None
 1.03A 2br4E-2pgeA:
undetectable		 2br4E-2pgeA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 10 ILE A 106
ALA A 104
LEU A 130
SER A  94
PHE A  84
 None
 1.04A 2w9sD-2pgeA:
undetectable		 2w9sD-2pgeA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 11 SER A  94
ARG A  88
SER A  98
ILE A 103
ALA A 329
 None
 1.16A 2zbzA-2pgeA:
undetectable		 2zbzA-2pgeA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 ALA A 128
GLY A 136
GLY A 135
VAL A  35
VAL A 112
 None
 0.96A 3m6wA-2pgeA:
undetectable		 3m6wA-2pgeA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2pge MENC
(Desulfotalea
psychrophila) 		3 / 3 TYR A 300
ASP A 108
ASP A 102
 None
 0.81A 4a6eA-2pgeA:
undetectable		 4a6eA-2pgeA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 10 ILE A  39
LEU A  81
GLY A  43
ASP A 131
GLY A 135
 None
 1.21A 4bwlC-2pgeA:
5.7		 4bwlC-2pgeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 MET A   5
LEU A  69
ILE A 103
ILE A 106
LEU A 132
 None
 1.30A 4j24C-2pgeA:
undetectable		 4j24C-2pgeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 ILE A 106
LEU A  69
LEU A 107
VAL A  35
LEU A  81
 None
 1.20A 4m11C-2pgeA:
undetectable		 4m11C-2pgeA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2pge MENC
(Desulfotalea
psychrophila) 		4 / 8 LEU A 107
VAL A 112
ALA A 128
LEU A  37
 None
 0.75A 4qrcA-2pgeA:
undetectable		 4qrcA-2pgeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 ALA A 224
ALA A 263
ILE A 262
MET A 251
GLN A 247
 None
 1.05A 4r38A-2pgeA:
undetectable		 4r38A-2pgeA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 ALA A 224
ALA A 263
ILE A 262
MET A 251
GLN A 247
 None
 1.00A 4r38C-2pgeA:
undetectable		 4r38C-2pgeA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 ALA A 224
ALA A 263
ILE A 262
MET A 251
GLN A 247
 None
 1.01A 4r38D-2pgeA:
undetectable		 4r38D-2pgeA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 12 ALA A 224
ALA A 263
ILE A 262
MET A 251
GLN A 247
 None
 1.04A 4r3aA-2pgeA:
undetectable		 4r3aA-2pgeA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 9 LEU A 290
LEU A  54
SER A 293
LEU A 295
ILE A 269
 None
 1.27A 4ubsA-2pgeA:
undetectable		 4ubsA-2pgeA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 11 LEU A 129
LEU A 132
LEU A  81
GLU A  87
LEU A  85
 None
 0.94A 4wg0B-2pgeA:
undetectable
4wg0C-2pgeA:
undetectable
4wg0D-2pgeA:
undetectable		 4wg0B-2pgeA:
3.31
4wg0C-2pgeA:
3.31
4wg0D-2pgeA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2pge MENC
(Desulfotalea
psychrophila) 		3 / 3 LYS A 182
ARG A 212
HIS A 237
 None
 1.14A 4zbrA-2pgeA:
1.5		 4zbrA-2pgeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 2pge MENC
(Desulfotalea
psychrophila) 		5 / 9 ALA A 301
GLY A 296
LEU A 295
LEU A 290
GLU A 322
 None
 1.14A 5dqfA-2pgeA:
undetectable		 5dqfA-2pgeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2pge MENC
(Desulfotalea
psychrophila) 		4 / 8 ALA A 335
PRO A 153
LEU A 366
LEU A 365
 None
 1.09A 5dzkd-2pgeA:
2.1
5dzkr-2pgeA:
undetectable		 5dzkd-2pgeA:
22.65
5dzkr-2pgeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2pge MENC
(Desulfotalea
psychrophila) 		4 / 8 ALA A 335
PRO A 153
LEU A 366
LEU A 365
 None
 1.11A 5dzkF-2pgeA:
2.2
5dzkT-2pgeA:
undetectable		 5dzkF-2pgeA:
22.65
5dzkT-2pgeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 2pge MENC
(Desulfotalea
psychrophila) 		4 / 7 ILE A 185
ILE A 158
ILE A 200
LEU A 181
 None
 0.71A 5fukA-2pgeA:
undetectable
5fukB-2pgeA:
undetectable		 5fukA-2pgeA:
21.64
5fukB-2pgeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2pge MENC
(Desulfotalea
psychrophila) 		4 / 8 ARG A  97
THR A 334
ILE A 330
PRO A 292
 None
 1.13A 6a4iA-2pgeA:
undetectable		 6a4iA-2pgeA:
21.31