SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 ASN A 158
CYH A 595
PRO A 320
GLY A 165
SER A 166
None
1.31A 1g60A-2pggA:
undetectable
1g60A-2pggA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 5 ARG A 592
ASP A 402
SER A 497
ASN A 423
None
1.50A 1kiaB-2pggA:
undetectable
1kiaB-2pggA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 ALA A 397
VAL A 407
TRP A 412
None
0.91A 1magA-2pggA:
undetectable
1magA-2pggA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 ALA A 397
VAL A 407
TRP A 412
None
0.91A 1magB-2pggA:
undetectable
1magB-2pggA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 6 ASN A 505
TRP A 504
GLY A 712
TRP A 388
None
1.25A 1mxdA-2pggA:
undetectable
1mxdA-2pggA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 ASN A 505
TRP A 504
GLY A 712
TRP A 388
None
1.25A 1mxgA-2pggA:
undetectable
1mxgA-2pggA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 ALA A 397
VAL A 407
TRP A 412
None
0.88A 1nt6A-2pggA:
undetectable
1nt6A-2pggA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 ALA A 397
VAL A 407
TRP A 412
None
0.88A 1nt6B-2pggA:
undetectable
1nt6B-2pggA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 LEU A  97
LEU A  79
LEU A 346
PRO A 343
LEU A 313
None
1.11A 1og5A-2pggA:
undetectable
1og5A-2pggA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 8 ASP A  76
ILE A  78
GLY A 272
ILE A 271
PRO A 229
None
1.04A 1sh9A-2pggA:
undetectable
1sh9A-2pggA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 GLY A 481
ASP A 467
ASN A 423
None
0.66A 1vq1A-2pggA:
2.6
1vq1A-2pggA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 5 LEU A 581
PRO A 586
VAL A 585
ILE A 583
None
1.01A 2aoiB-2pggA:
undetectable
2aoiB-2pggA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 5 LEU A 254
ILE A 252
LEU A 346
SER A 342
None
1.00A 2byoA-2pggA:
undetectable
2byoA-2pggA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 SER A 687
SER A 689
ARG A 627
GLU A 688
None
0.98A 2c8aA-2pggA:
undetectable
2c8aA-2pggA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 SER A 687
SER A 689
ARG A 627
GLU A 688
None
0.97A 2c8aB-2pggA:
undetectable
2c8aB-2pggA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 6 SER A 687
SER A 689
ARG A 627
GLU A 688
None
0.99A 2c8aC-2pggA:
undetectable
2c8aC-2pggA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 SER A 687
SER A 689
ARG A 627
GLU A 688
None
1.00A 2c8aD-2pggA:
undetectable
2c8aD-2pggA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 TRP A 504
LYS A 523
PRO A 510
None
1.28A 2dqyB-2pggA:
2.6
2dqyB-2pggA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 GLY A 551
ASP A 580
VAL A 585
VAL A 685
VAL A 587
None
0.98A 2f8gA-2pggA:
undetectable
2f8gA-2pggA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 GLY A 730
ASP A 766
ASN A 727
ASP A 763
None
1.04A 2g72B-2pggA:
undetectable
2g72B-2pggA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 ARG A 542
ALA A 575
ILE A 385
ILE A 534
LEU A 390
None
1.00A 2o4nA-2pggA:
undetectable
2o4nA-2pggA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 ASN A 492
LEU A 496
HIS A 428
None
0.72A 2q6fB-2pggA:
undetectable
2q6fB-2pggA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 SER A 777
HIS A 758
ASP A 764
None
0.63A 2wa2B-2pggA:
undetectable
2wa2B-2pggA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 PRO A 100
LEU A  67
ARG A  65
None
0.88A 3aqiA-2pggA:
undetectable
3aqiA-2pggA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 8 LEU A 693
SER A 689
THR A 684
VAL A 685
None
0.90A 3ax9A-2pggA:
undetectable
3ax9A-2pggA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 SER A 574
TRP A 573
GLU A 531
ASP A 416
None
1.28A 3bc9A-2pggA:
undetectable
3bc9A-2pggA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 9 ASP A  76
ILE A  78
GLY A 272
ILE A 271
PRO A 229
None
1.02A 3ekyB-2pggA:
undetectable
3ekyB-2pggA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 ILE A 404
LEU A 499
GLN A 503
LEU A 713
VAL A 399
None
1.10A 3ix9B-2pggA:
undetectable
3ix9B-2pggA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 8 ILE A 472
PRO A 112
SER A 339
PRO A 320
None
0.94A 3lslA-2pggA:
undetectable
3lslD-2pggA:
undetectable
3lslA-2pggA:
16.43
3lslD-2pggA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 8 PRO A 320
ILE A 472
PRO A 112
SER A 339
None
0.88A 3lslA-2pggA:
undetectable
3lslD-2pggA:
undetectable
3lslA-2pggA:
16.43
3lslD-2pggA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 LEU A 313
GLY A 316
THR A 344
LEU A 464
SER A 468
None
1.32A 3ndvC-2pggA:
undetectable
3ndvD-2pggA:
undetectable
3ndvC-2pggA:
18.81
3ndvD-2pggA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 ASP A  76
ILE A  78
GLY A 272
ILE A 271
PRO A 229
None
1.05A 3ndxA-2pggA:
undetectable
3ndxA-2pggA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 LEU A 249
GLY A 268
THR A 266
SER A 256
LEU A 346
None
1.21A 3okxA-2pggA:
undetectable
3okxA-2pggA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 LEU A 249
GLY A 268
THR A 266
SER A 256
LEU A 346
None
1.17A 3okxB-2pggA:
undetectable
3okxB-2pggA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 5 LEU A 475
ARG A  55
LEU A  50
PRO A  47
None
1.19A 3onnA-2pggA:
undetectable
3onnA-2pggA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 5 TYR A 197
THR A 198
PHE A 199
LEU A 206
None
0.89A 3qelC-2pggA:
undetectable
3qelC-2pggA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 HIS A 758
GLY A 445
SER A 442
PHE A 449
ASN A 450
None
1.41A 3v3nA-2pggA:
undetectable
3v3nA-2pggA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 HIS A 758
GLY A 445
SER A 442
PHE A 449
ASN A 450
None
1.41A 3v3nD-2pggA:
undetectable
3v3nD-2pggA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 GLN A 451
THR A 455
ALA A 454
LEU A 437
PHE A 449
None
1.48A 4claA-2pggA:
undetectable
4claA-2pggA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 GLY A 673
SER A 667
TRP A 666
None
0.95A 4e7cD-2pggA:
undetectable
4e7cD-2pggA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 THR A 438
LEU A 720
GLN A 503
LEU A 499
None
0.95A 4ib4A-2pggA:
3.0
4ib4A-2pggA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 THR A 565
LEU A 637
LYS A 639
LEU A 148
None
1.12A 4ib4A-2pggA:
3.0
4ib4A-2pggA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 LEU A 382
PRO A 377
ARG A 532
None
0.69A 4klrB-2pggA:
undetectable
4klrB-2pggA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 THR A 498
LEU A 205
THR A 209
THR A 722
None
0.89A 4mbsA-2pggA:
undetectable
4mbsA-2pggA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 LEU A 130
LEU A 637
ALA A 625
LEU A 626
TYR A 623
None
1.18A 4wg0F-2pggA:
undetectable
4wg0G-2pggA:
undetectable
4wg0H-2pggA:
undetectable
4wg0F-2pggA:
2.57
4wg0G-2pggA:
2.57
4wg0H-2pggA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 LEU A 130
LEU A 637
ALA A 625
LEU A 626
TYR A 623
None
1.16A 4wg0H-2pggA:
undetectable
4wg0I-2pggA:
undetectable
4wg0J-2pggA:
undetectable
4wg0H-2pggA:
2.57
4wg0I-2pggA:
2.57
4wg0J-2pggA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 ALA A 625
LEU A 626
TYR A 623
LEU A 637
LEU A 130
None
1.18A 4wg0G-2pggA:
undetectable
4wg0H-2pggA:
undetectable
4wg0I-2pggA:
undetectable
4wg0G-2pggA:
2.57
4wg0H-2pggA:
2.57
4wg0I-2pggA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 LEU A 130
LEU A 637
ALA A 625
LEU A 626
TYR A 623
None
1.15A 4wg0J-2pggA:
undetectable
4wg0K-2pggA:
undetectable
4wg0L-2pggA:
undetectable
4wg0J-2pggA:
2.57
4wg0K-2pggA:
2.57
4wg0L-2pggA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 ALA A 625
LEU A 626
TYR A 623
LEU A 637
LEU A 130
None
1.18A 4wg0I-2pggA:
undetectable
4wg0J-2pggA:
undetectable
4wg0K-2pggA:
undetectable
4wg0I-2pggA:
2.57
4wg0J-2pggA:
2.57
4wg0K-2pggA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 GLU A 418
LYS A 529
ASN A 527
None
1.03A 4y1dA-2pggA:
undetectable
4y1dD-2pggA:
undetectable
4y1dA-2pggA:
13.40
4y1dD-2pggA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 5 VAL A 697
TYR A 405
ILE A 406
THR A 209
None
1.33A 4ze1A-2pggA:
undetectable
4ze1A-2pggA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 11 LEU A 372
LEU A 390
LEU A 568
LEU A 570
LEU A 541
None
0.86A 4zowA-2pggA:
undetectable
4zowA-2pggA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 TYR A 480
LYS A  60
LYS A 478
None
1.18A 5dbyA-2pggA:
4.0
5dbyA-2pggA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 GLY A 730
GLY A 440
GLY A 445
VAL A 355
ILE A 436
None
0.97A 5ehgC-2pggA:
undetectable
5ehgC-2pggA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
5 / 12 LEU A 289
LEU A 437
LEU A 225
PHE A 456
ALA A 461
None
1.17A 5iepA-2pggA:
undetectable
5iepA-2pggA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 GLY A 730
ASN A 727
ARG A 439
None
0.74A 5w7bD-2pggA:
undetectable
5w7bD-2pggA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 SER A 469
SER A 314
ALA A 803
None
0.73A 6dwnC-2pggA:
undetectable
6dwnC-2pggA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
3 / 3 TYR A 373
HIS A 494
PHE A 490
None
0.91A 6esmA-2pggA:
undetectable
6esmA-2pggA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal
disease
virus)
4 / 7 ALA A 487
THR A 352
ILE A 436
ALA A 432
None
0.95A 6ma7A-2pggA:
undetectable
6ma7A-2pggA:
7.61