SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A 336
LEU A 343
VAL A 342
LEU A 306
ALA A 309
 None
 0.99A 1gseB-2pgsA:
undetectable		 1gseB-2pgsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		5 / 11 VAL A  81
GLY A  82
LEU A  98
HIS A 233
PHE A 314
 None
 1.36A 1iolA-2pgsA:
undetectable		 1iolA-2pgsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		4 / 7 ALA A 296
ILE A 303
ILE A 250
GLU A 253
 None
 0.98A 1oniD-2pgsA:
undetectable
1oniF-2pgsA:
undetectable		 1oniD-2pgsA:
16.23
1oniF-2pgsA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		4 / 6 LEU A 322
TRP A   5
LEU A  85
PHE A 314
 None
 1.16A 1ru9H-2pgsA:
undetectable
1ru9L-2pgsA:
undetectable		 1ru9H-2pgsA:
17.72
1ru9L-2pgsA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 ILE A 111
GLY A 112
GLY A 117
HIS A 118
ALA A 155
 None
 0.74A 1vptA-2pgsA:
undetectable		 1vptA-2pgsA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		4 / 5 LEU A 370
GLY A 153
ALA A 123
ILE A 124
 None
 0.84A 2aohB-2pgsA:
undetectable		 2aohB-2pgsA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		5 / 8 HIS A  33
LEU A 161
ILE A 111
THR A 179
LEU A 175
 None
 1.40A 2xfhA-2pgsA:
undetectable		 2xfhA-2pgsA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 THR A 179
LEU A 175
THR A 173
VAL A 160
ILE A  36
 None
 1.22A 3bf1A-2pgsA:
undetectable
3bf1B-2pgsA:
undetectable		 3bf1A-2pgsA:
19.38
3bf1B-2pgsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 ALA A 345
LEU A 249
LEU A 252
HIS A 305
LEU A 306
 None
 1.19A 3erdA-2pgsA:
undetectable		 3erdA-2pgsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		3 / 3 GLY A 181
PRO A 234
LEU A   8
 None
 0.61A 3hcpB-2pgsA:
undetectable		 3hcpB-2pgsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		4 / 8 LEU A   9
ARG A  11
THR A 176
GLY A  78
 None
 0.93A 3ny4A-2pgsA:
undetectable		 3ny4A-2pgsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		5 / 9 ALA A 131
GLY A 133
LEU A 149
LEU A 137
ASP A 138
 None
 1.22A 3wdmC-2pgsA:
undetectable		 3wdmC-2pgsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		4 / 7 PHE A 169
SER A 208
ALA A 414
ARG A 418
 None
 1.25A 4lv9A-2pgsA:
undetectable
4lv9B-2pgsA:
undetectable		 4lv9A-2pgsA:
21.63
4lv9B-2pgsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		4 / 6 ASP A 110
ALA A 108
TYR A 183
ASP A 243
 None
 1.21A 4mdaA-2pgsA:
undetectable		 4mdaA-2pgsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		4 / 6 ASP A 110
ALA A 108
TYR A 183
ASP A 243
 None
 1.17A 4mdbA-2pgsA:
undetectable		 4mdbA-2pgsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 235
LEU A 330
VAL A 315
THR A 307
ILE A 245
 None
 1.37A 4okbA-2pgsA:
undetectable		 4okbA-2pgsA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 252
VAL A 342
LEU A 273
VAL A 274
GLY A 300
 None
 1.44A 5i8fA-2pgsA:
undetectable		 5i8fA-2pgsA:
19.13