SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 9 ASP A 334
ILE A 305
ALA A 112
ILE A  48
THR A 303
 None
 1.23A 1aj6A-2pgwA:
undetectable		 1aj6A-2pgwA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		4 / 4 ILE A 270
MET A 282
VAL A 137
GLY A 271
 None
 1.26A 1e06B-2pgwA:
undetectable		 1e06B-2pgwA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 8 GLY A  49
ILE A 305
PRO A 272
ILE A 313
ILE A 278
 None
 1.09A 1hshD-2pgwA:
undetectable		 1hshD-2pgwA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 9 GLY A 355
GLY A  49
ILE A 305
PRO A 272
ILE A 278
 None
 1.08A 1hxwA-2pgwA:
undetectable		 1hxwA-2pgwA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 GLY A 355
GLY A  49
ILE A 305
PRO A 272
ILE A 278
 None
 0.93A 1n49B-2pgwA:
undetectable		 1n49B-2pgwA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A 213
TYR A 216
GLY A 173
GLY A 171
ILE A 180
 None
 1.10A 1p91A-2pgwA:
undetectable		 1p91A-2pgwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A  53
LEU A  16
THR A 306
ILE A 305
LEU A  36
 None
 1.11A 1qzfA-2pgwA:
undetectable		 1qzfA-2pgwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A  53
LEU A  16
THR A 306
ILE A 305
LEU A  36
 None
 1.10A 1qzfB-2pgwA:
undetectable		 1qzfB-2pgwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A  53
LEU A  16
THR A 306
ILE A 305
LEU A  36
 None
 1.10A 1qzfC-2pgwA:
undetectable		 1qzfC-2pgwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A  53
LEU A  16
THR A 306
ILE A 305
LEU A  36
 None
 1.11A 1qzfD-2pgwA:
undetectable		 1qzfD-2pgwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A  53
LEU A  16
THR A 306
ILE A 305
LEU A  36
 None
 1.11A 1qzfE-2pgwA:
undetectable		 1qzfE-2pgwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 271
ALA A 284
ILE A 275
GLY A 314
ALA A 285
 None
 1.01A 1utdL-2pgwA:
undetectable
1utdM-2pgwA:
undetectable		 1utdL-2pgwA:
9.87
1utdM-2pgwA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 271
ALA A 284
ILE A 275
GLY A 314
ALA A 285
 None
 0.99A 1utdO-2pgwA:
undetectable
1utdP-2pgwA:
undetectable		 1utdO-2pgwA:
9.87
1utdP-2pgwA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 GLY A 271
ALA A 284
ILE A 275
GLY A 314
ALA A 285
 None
 0.97A 1utdP-2pgwA:
undetectable
1utdQ-2pgwA:
undetectable		 1utdP-2pgwA:
9.87
1utdQ-2pgwA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		4 / 8 GLY A  59
THR A  60
ALA A  61
VAL A  15
 None
 0.85A 2a1hA-2pgwA:
undetectable
2a1hB-2pgwA:
undetectable		 2a1hA-2pgwA:
22.65
2a1hB-2pgwA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		4 / 8 VAL A  15
GLY A  59
THR A  60
ALA A  61
 None
 0.88A 2a1hA-2pgwA:
undetectable
2a1hB-2pgwA:
undetectable		 2a1hA-2pgwA:
22.65
2a1hB-2pgwA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		3 / 3 ASN A   8
ILE A  37
MET A 113
 None
 0.82A 2h42C-2pgwA:
undetectable		 2h42C-2pgwA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A 312
LEU A  14
ASP A 334
GLY A 304
ALA A 361
 None
 1.22A 2kceB-2pgwA:
undetectable		 2kceB-2pgwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A  61
GLY A  59
LEU A  36
THR A 303
LEU A  16
 None
 0.97A 2nyuB-2pgwA:
undetectable		 2nyuB-2pgwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		4 / 5 ASP A 196
TYR A 167
CYH A 296
PHE A 220
 None
 1.48A 2todA-2pgwA:
5.5
2todB-2pgwA:
5.4		 2todA-2pgwA:
21.72
2todB-2pgwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		4 / 5 CYH A 296
PHE A 220
ASP A 196
TYR A 167
 None
 1.49A 2todC-2pgwA:
8.2
2todD-2pgwA:
7.5		 2todC-2pgwA:
21.72
2todD-2pgwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 THR A 302
ILE A 335
ARG A 371
THR A 306
VAL A 331
 None
 1.32A 3ijdA-2pgwA:
5.8		 3ijdA-2pgwA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 265
ILE A 221
ASP A 196
ALA A 197
GLN A 248
 None
 1.07A 3nvkI-2pgwA:
2.9		 3nvkI-2pgwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		6 / 12 GLY A 355
GLY A  49
ILE A 305
PRO A 272
ILE A 313
ILE A 278
 None
 1.21A 3s54A-2pgwA:
undetectable		 3s54A-2pgwA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		3 / 3 GLU A  40
GLY A  44
SER A   7
 None
 0.46A 4b53B-2pgwA:
undetectable		 4b53B-2pgwA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A  39
ALA A 112
GLY A  49
GLU A  50
GLY A 276
 None
 1.17A 4e47A-2pgwA:
undetectable		 4e47A-2pgwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A  39
ALA A 112
GLY A  49
GLU A  50
GLY A 276
 None
 1.20A 4e47B-2pgwA:
undetectable		 4e47B-2pgwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A  39
ALA A 112
GLY A  49
GLU A  50
GLY A 276
 None
 1.17A 4e47C-2pgwA:
undetectable		 4e47C-2pgwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A  39
ALA A 112
GLY A  49
GLU A  50
GLY A 276
 None
 1.20A 4jdsA-2pgwA:
undetectable		 4jdsA-2pgwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A  39
ALA A 112
GLY A  49
GLU A  50
GLY A 276
 None
 1.19A 4jdsB-2pgwA:
undetectable		 4jdsB-2pgwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  39
ALA A 112
GLY A  49
GLU A  50
GLY A 276
 None
 1.20A 4jlgA-2pgwA:
undetectable		 4jlgA-2pgwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 180
ALA A 155
LEU A 143
LEU A 193
ILE A 188
 None
 1.12A 4lnwA-2pgwA:
undetectable		 4lnwA-2pgwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 180
ALA A 155
LEU A 143
LEU A 193
ILE A 188
 None
 1.14A 4lnxA-2pgwA:
undetectable		 4lnxA-2pgwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A 192
ASP A 321
ARG A 164
 None
 0.82A 4mx0A-2pgwA:
undetectable		 4mx0A-2pgwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A  39
ALA A 112
GLY A  49
GLU A  50
GLY A 276
 None
 1.17A 5ayfA-2pgwA:
undetectable		 5ayfA-2pgwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		6 / 12 GLY A 355
GLY A  49
ILE A 305
PRO A 272
ILE A 313
ILE A 278
 None
 1.17A 5e5jB-2pgwA:
undetectable		 5e5jB-2pgwA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		6 / 12 LEU A  36
GLY A  47
ALA A 112
ASP A 110
ILE A 109
ILE A  37
 None
 1.49A 5e5jB-2pgwA:
undetectable		 5e5jB-2pgwA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		4 / 7 ILE A 275
GLY A 276
CYH A 269
PHE A 301
 None
 0.84A 5hieA-2pgwA:
undetectable		 5hieA-2pgwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		4 / 7 ILE A 275
GLY A 276
CYH A 269
PHE A 301
 None
 0.84A 5hieB-2pgwA:
undetectable		 5hieB-2pgwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		4 / 8 ILE A 275
GLY A 276
CYH A 269
PHE A 301
 None
 0.86A 5hieD-2pgwA:
undetectable		 5hieD-2pgwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2pgw MUCONATE
CYCLOISOMERASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A 304
THR A 307
ILE A 326
PHE A 140
 None
 0.90A 6f8cA-2pgwA:
undetectable		 6f8cA-2pgwA:
12.15