SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ph3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 10 LEU A  28
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 0.97A 1hsgA-2ph3A:
undetectable		 1hsgA-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  21
THR A 118
VAL A  71
LEU A  81
LEU A  28
 None
 1.03A 1mx1C-2ph3A:
4.2		 1mx1C-2ph3A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 ALA A  18
GLY A  14
SER A  10
ALA A  46
ARG A  47
 None
 0.99A 1ve3A-2ph3A:
6.2		 1ve3A-2ph3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 ALA A  18
GLY A  14
SER A  10
ALA A  46
ARG A  47
 None
 1.02A 1ve3B-2ph3A:
2.1		 1ve3B-2ph3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.87A 2avvE-2ph3A:
undetectable		 2avvE-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.97A 2f80B-2ph3A:
undetectable		 2f80B-2ph3A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 0.98A 2f8gA-2ph3A:
undetectable		 2f8gA-2ph3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.94A 2hs2B-2ph3A:
undetectable		 2hs2B-2ph3A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.12A 2ienA-2ph3A:
undetectable		 2ienA-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  28
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 0.96A 2o4pB-2ph3A:
undetectable		 2o4pB-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.97A 2pymA-2ph3A:
undetectable		 2pymA-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.97A 2pymB-2ph3A:
undetectable		 2pymB-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.98A 2pynA-2ph3A:
undetectable		 2pynA-2ph3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 1.01A 2pynB-2ph3A:
undetectable		 2pynB-2ph3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.98A 2pynB-2ph3A:
undetectable		 2pynB-2ph3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.06A 2q63A-2ph3A:
undetectable		 2q63A-2ph3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.93A 2q63B-2ph3A:
undetectable		 2q63B-2ph3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.89A 2q64A-2ph3A:
undetectable		 2q64A-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.03A 2q64B-2ph3A:
undetectable		 2q64B-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 10 ILE A 175
GLY A 174
PHE A 131
GLY A 229
THR A 232
 None
 1.40A 2y7wB-2ph3A:
undetectable		 2y7wB-2ph3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 GLY A   8
ILE A  17
ALA A  59
VAL A  85
LEU A   5
VAL A  71
 None
 1.49A 2yqzB-2ph3A:
6.3		 2yqzB-2ph3A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		4 / 8 ILE A 137
ASN A 111
SER A 155
SER A 139
 None
 1.06A 2zw9B-2ph3A:
5.1		 2zw9B-2ph3A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.11A 3bvbA-2ph3A:
undetectable		 3bvbA-2ph3A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 GLN A 204
TYR A 152
GLY A 183
ILE A 205
GLY A 211
 None
 0.98A 3bwcA-2ph3A:
5.7		 3bwcA-2ph3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 GLN A 204
TYR A 152
ILE A 185
GLY A 183
GLY A 211
 None
 0.91A 3bwcA-2ph3A:
5.7		 3bwcA-2ph3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.96A 3cywB-2ph3A:
undetectable		 3cywB-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.92A 3d1xB-2ph3A:
undetectable		 3d1xB-2ph3A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.05A 3d20A-2ph3A:
undetectable		 3d20A-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.95A 3d20B-2ph3A:
undetectable		 3d20B-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 10 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.05A 3em3A-2ph3A:
undetectable		 3em3A-2ph3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.94A 3jvyA-2ph3A:
undetectable		 3jvyA-2ph3A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.09A 3jw2A-2ph3A:
undetectable		 3jw2A-2ph3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.11A 3jw2B-2ph3A:
undetectable		 3jw2B-2ph3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.85A 3k4vB-2ph3A:
undetectable		 3k4vB-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 10 ASN A 146
VAL A 141
TYR A 152
GLY A 145
TYR A 201
 None
 1.47A 3lp1A-2ph3A:
undetectable		 3lp1A-2ph3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.94A 3lzsA-2ph3A:
undetectable		 3lzsA-2ph3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 1.00A 3lzsB-2ph3A:
undetectable		 3lzsB-2ph3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.98A 3lzuA-2ph3A:
undetectable		 3lzuA-2ph3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.93A 3ndtC-2ph3A:
undetectable		 3ndtC-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.94A 3ndtD-2ph3A:
undetectable		 3ndtD-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.95A 3nduB-2ph3A:
undetectable		 3nduB-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.98A 3nduD-2ph3A:
undetectable		 3nduD-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 1.01A 3nu3A-2ph3A:
undetectable		 3nu3A-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 11 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.84A 3nu3B-2ph3A:
undetectable		 3nu3B-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.04A 3nu5A-2ph3A:
undetectable		 3nu5A-2ph3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.87A 3nu5B-2ph3A:
undetectable		 3nu5B-2ph3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 10 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.05A 3nu6B-2ph3A:
undetectable		 3nu6B-2ph3A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.87A 3nujB-2ph3A:
undetectable		 3nujB-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.86A 3nuoB-2ph3A:
undetectable		 3nuoB-2ph3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.97A 3oxvA-2ph3A:
undetectable		 3oxvA-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.90A 3oxvC-2ph3A:
undetectable		 3oxvC-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 10 LEU A  28
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.03A 3oxwD-2ph3A:
undetectable		 3oxwD-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.90A 3oxxA-2ph3A:
undetectable		 3oxxA-2ph3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 11 LEU A  28
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 0.94A 3oy4A-2ph3A:
undetectable		 3oy4A-2ph3A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.97A 3pwmB-2ph3A:
undetectable		 3pwmB-2ph3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 1.00A 3pwrA-2ph3A:
undetectable		 3pwrA-2ph3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.93A 3pwrB-2ph3A:
undetectable		 3pwrB-2ph3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.89A 3pwrB-2ph3A:
undetectable		 3pwrB-2ph3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.96A 3tkgA-2ph3A:
undetectable		 3tkgA-2ph3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 1.02A 3tkgB-2ph3A:
undetectable		 3tkgB-2ph3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 1.00A 3tkgD-2ph3A:
undetectable		 3tkgD-2ph3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.99A 3tkgD-2ph3A:
undetectable		 3tkgD-2ph3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.08A 3tkwB-2ph3A:
undetectable		 3tkwB-2ph3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.06A 3tl9B-2ph3A:
undetectable		 3tl9B-2ph3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		4 / 5 SER A 139
ILE A  13
TYR A 152
GLY A 183
 None
 1.03A 3uboB-2ph3A:
7.2		 3uboB-2ph3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 11 ILE A  17
ILE A  13
GLY A  12
VAL A 238
GLY A 211
 None
 0.95A 4ac9B-2ph3A:
4.4
4ac9C-2ph3A:
3.8		 4ac9B-2ph3A:
19.51
4ac9C-2ph3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 11 LEU A  28
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 0.96A 4dqeA-2ph3A:
undetectable		 4dqeA-2ph3A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 10 GLU A  41
VAL A  56
ALA A   9
ALA A  18
ILE A  30
 None
 1.07A 4lbgA-2ph3A:
7.1		 4lbgA-2ph3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		4 / 8 PRO A 182
VAL A 216
VAL A 141
GLY A 142
 None
 0.89A 4mk4A-2ph3A:
2.4		 4mk4A-2ph3A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 9 PHE A 222
ALA A 219
ALA A 217
LEU A 223
VAL A 224
 None
 1.19A 4or0A-2ph3A:
undetectable		 4or0A-2ph3A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 11 LEU A  28
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 0.95A 4qgiB-2ph3A:
undetectable		 4qgiB-2ph3A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.85A 4rvjB-2ph3A:
undetectable		 4rvjB-2ph3A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.86A 4rvjD-2ph3A:
undetectable		 4rvjD-2ph3A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		4 / 5 LEU A  21
ASP A  24
LEU A  28
THR A  83
 None
 1.24A 4wozF-2ph3A:
undetectable
4wozH-2ph3A:
3.6		 4wozF-2ph3A:
24.44
4wozH-2ph3A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		4 / 6 ILE A 185
PRO A 213
ILE A   6
VAL A  85
 None
 0.98A 4zj8A-2ph3A:
6.1		 4zj8A-2ph3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		4 / 6 GLU A  41
GLY A  25
ASP A  24
GLY A  50
 None
 0.95A 5cdnC-2ph3A:
undetectable
5cdnD-2ph3A:
2.5		 5cdnC-2ph3A:
21.67
5cdnD-2ph3A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		3 / 3 THR A  83
PRO A  52
ARG A  47
 None
 0.88A 5nd7B-2ph3A:
7.2		 5nd7B-2ph3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.99A 6dh6A-2ph3A:
undetectable		 6dh6A-2ph3A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  54
ILE A  30
 None
 0.89A 6difB-2ph3A:
undetectable		 6difB-2ph3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
 None
 0.89A 6difB-2ph3A:
undetectable		 6difB-2ph3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE
(Thermus
thermophilus) 		6 / 12 LEU A  28
GLY A  14
ALA A   9
VAL A  56
VAL A  54
ILE A  30
 None
 1.02A 6dilB-2ph3A:
undetectable		 6dilB-2ph3A:
17.48