SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ph5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 8 ASP A 357
ASP A 209
TYR A 319
THR A 225
 None
 1.47A 1ceaA-2ph5A:
undetectable
1ceaB-2ph5A:
undetectable		 1ceaA-2ph5A:
11.63
1ceaB-2ph5A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 8 LEU A  31
ALA A  27
LEU A  19
THR A  44
 None
 0.80A 1dvtA-2ph5A:
undetectable
1dvtB-2ph5A:
undetectable		 1dvtA-2ph5A:
14.70
1dvtB-2ph5A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 12 TYR A 135
GLY A 260
ILE A 297
CYH A 263
GLN A 262
 None
 1.20A 2azxA-2ph5A:
2.9		 2azxA-2ph5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 12 TYR A 135
GLY A 260
ILE A 297
CYH A 263
GLN A 262
 None
 1.19A 2azxB-2ph5A:
undetectable		 2azxB-2ph5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 9 ILE A 379
ILE A 348
GLU A 351
GLN A 211
THR A 225
 None
 1.32A 2dtjA-2ph5A:
undetectable
2dtjB-2ph5A:
undetectable		 2dtjA-2ph5A:
17.88
2dtjB-2ph5A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 6 ASP A 443
THR A 442
TYR A 441
HIS A 204
 None
 1.34A 2eimN-2ph5A:
undetectable
2eimP-2ph5A:
undetectable		 2eimN-2ph5A:
23.02
2eimP-2ph5A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		3 / 3 SER A 227
THR A  51
GLN A  26
 NAD  A 501 ( 4.5A)
None
None
 0.65A 2fk8A-2ph5A:
undetectable		 2fk8A-2ph5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 11 ILE A 415
GLY A 107
ALA A 108
ASP A  85
GLY A  78
 None
 0.90A 2fxdA-2ph5A:
undetectable		 2fxdA-2ph5A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		3 / 3 LEU A 236
LEU A 290
MET A 275
 None
 0.79A 2itzA-2ph5A:
undetectable		 2itzA-2ph5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 10 SER A 271
ILE A 291
ASN A 224
LEU A 231
ASN A 229
 None
 1.24A 2nnhB-2ph5A:
undetectable		 2nnhB-2ph5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 6 LEU A  28
ILE A  18
MET A 400
ILE A 404
 None
 0.81A 2piwA-2ph5A:
undetectable		 2piwA-2ph5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 8 CYH A 263
THR A 296
ILE A 297
THR A 300
 None
 0.77A 3bpxA-2ph5A:
undetectable
3bpxB-2ph5A:
undetectable		 3bpxA-2ph5A:
15.50
3bpxB-2ph5A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 6 ALA A 239
ILE A 241
HIS A 318
VAL A 276
 None
 1.14A 3nneG-2ph5A:
undetectable		 3nneG-2ph5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 9 GLY A 107
ALA A 108
ASP A  85
GLY A  78
ILE A 100
 None
 1.00A 3s53A-2ph5A:
undetectable		 3s53A-2ph5A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 8 VAL A 276
HIS A 204
PRO A 251
TRP A 243
 None
 1.05A 3v35A-2ph5A:
undetectable		 3v35A-2ph5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 12 VAL A 317
ILE A 203
GLU A 417
HIS A 293
VAL A 361
 None
 1.30A 4a97B-2ph5A:
undetectable
4a97C-2ph5A:
undetectable		 4a97B-2ph5A:
20.61
4a97C-2ph5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		3 / 3 LYS A 306
THR A 304
ILE A 297
 None
 0.82A 4e0fB-2ph5A:
undetectable		 4e0fB-2ph5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		3 / 3 LYS A  39
PRO A  40
SER A  41
 None
 0.51A 4k50I-2ph5A:
undetectable		 4k50I-2ph5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 5 THR A 392
THR A 225
ASP A 209
TYR A 321
 None
 1.42A 4oltA-2ph5A:
undetectable		 4oltA-2ph5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 5 THR A 392
THR A 225
ASP A 209
TYR A 321
 None
 1.39A 4oltB-2ph5A:
undetectable		 4oltB-2ph5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 7 THR A 300
THR A 155
LEU A 142
SER A 164
 None
 1.15A 4pfjA-2ph5A:
8.0		 4pfjA-2ph5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 5 THR A 392
THR A 225
ASP A 209
TYR A 321
 None
 1.40A 4qwpA-2ph5A:
undetectable		 4qwpA-2ph5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 5 THR A 392
THR A 225
ASP A 209
TYR A 321
 None
 1.41A 4qwpB-2ph5A:
undetectable		 4qwpB-2ph5A:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		11 / 12 ALA A 158
ASN A 159
PRO A 160
GLU A 207
TRP A 226
GLU A 234
TYR A 319
TYR A 321
ASP A 357
LEU A 359
THR A 392
 NAD  A 501 (-3.3A)
NAD  A 501 (-4.5A)
NAD  A 501 (-3.8A)
None
None
None
None
None
None
None
None
 0.51A 4xqeA-2ph5A:
54.5		 4xqeA-2ph5A:
45.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		11 / 12 ALA A 158
ASN A 159
PRO A 160
GLU A 207
TRP A 226
GLU A 234
TYR A 319
TYR A 321
ASP A 357
LEU A 359
THR A 392
 NAD  A 501 (-3.3A)
NAD  A 501 (-4.5A)
NAD  A 501 (-3.8A)
None
None
None
None
None
None
None
None
 0.53A 4xqeB-2ph5A:
54.5		 4xqeB-2ph5A:
45.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		10 / 12 ASN A 159
PRO A 160
GLU A 207
TRP A 226
GLU A 234
TYR A 319
TYR A 321
ASP A 357
LEU A 359
THR A 392
 NAD  A 501 (-4.5A)
NAD  A 501 (-3.8A)
None
None
None
None
None
None
None
None
 0.57A 4xrgA-2ph5A:
54.6		 4xrgA-2ph5A:
45.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		11 / 12 ALA A 158
ASN A 159
PRO A 160
GLU A 207
TRP A 226
GLU A 234
TYR A 319
TYR A 321
ASP A 357
LEU A 359
THR A 392
 NAD  A 501 (-3.3A)
NAD  A 501 (-4.5A)
NAD  A 501 (-3.8A)
None
None
None
None
None
None
None
None
 0.54A 4xrgB-2ph5A:
54.5		 4xrgB-2ph5A:
45.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		3 / 3 LYS A  64
ILE A  46
ILE A  77
 None
 0.72A 4y0qA-2ph5A:
undetectable		 4y0qA-2ph5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 7 ILE A 426
LEU A 162
GLU A 295
GLY A 157
 None
None
None
NAD  A 501 (-3.0A)
 0.83A 5a06A-2ph5A:
5.9		 5a06A-2ph5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 7 ILE A 426
LEU A 162
GLU A 295
GLY A 157
 None
None
None
NAD  A 501 (-3.0A)
 0.82A 5a06B-2ph5A:
5.7		 5a06B-2ph5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 7 ILE A 426
LEU A 162
GLU A 295
GLY A 157
 None
None
None
NAD  A 501 (-3.0A)
 0.84A 5a06C-2ph5A:
5.9		 5a06C-2ph5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 7 ILE A 426
LEU A 162
GLU A 295
GLY A 157
 None
None
None
NAD  A 501 (-3.0A)
 0.84A 5a06E-2ph5A:
5.9		 5a06E-2ph5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 7 ILE A 426
LEU A 162
GLU A 295
GLY A 157
 None
None
None
NAD  A 501 (-3.0A)
 0.81A 5a06F-2ph5A:
5.9		 5a06F-2ph5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 12 ILE A 401
LEU A  28
VAL A  61
ILE A  38
GLY A  60
 None
 1.17A 5ienA-2ph5A:
undetectable		 5ienA-2ph5A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 12 ILE A 200
GLY A 365
ASN A 366
GLU A 419
ALA A 175
 None
 1.22A 5igyA-2ph5A:
0.5		 5igyA-2ph5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		5 / 10 TYR A 433
ILE A  32
ILE A 404
ILE A 405
ILE A 408
 None
 0.89A 5murE-2ph5A:
undetectable		 5murE-2ph5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 8 ASP A 357
LEU A 359
THR A 392
TYR A 321
 None
 1.17A 5ov9B-2ph5A:
undetectable		 5ov9B-2ph5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 4 ASP A 462
SER A 461
ASP A 459
HIS A 249
 None
 1.41A 5wyqB-2ph5A:
1.2		 5wyqB-2ph5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2ph5 HOMOSPERMIDINE
SYNTHASE
(Legionella
pneumophila) 		4 / 6 GLN A 395
VAL A 396
ALA A 113
THR A 155
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-3.4A)
None
 0.78A 6cduB-2ph5A:
undetectable
6cduC-2ph5A:
undetectable		 6cduB-2ph5A:
21.21
6cduC-2ph5A:
21.21