SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2phc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		4 / 4 ILE B 185
LEU B 128
VAL B 200
ILE B 199
 None
 0.91A 1fm6D-2phcB:
undetectable		 1fm6D-2phcB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		5 / 8 ILE B  88
ILE B 185
GLY B 183
ILE B 182
PRO B 210
 None
 1.46A 1sh9A-2phcB:
undetectable		 1sh9A-2phcB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		4 / 7 THR B 168
VAL B 206
VAL B  90
ILE B 185
 None
 0.93A 1t87B-2phcB:
undetectable		 1t87B-2phcB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		4 / 8 THR B 168
VAL B 206
VAL B  90
ILE B 185
 None
 0.94A 2qbmA-2phcB:
undetectable		 2qbmA-2phcB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		4 / 7 ALA B 135
ALA B 172
VAL B 125
ILE B  86
 None
 0.75A 3a2qA-2phcB:
undetectable		 3a2qA-2phcB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		4 / 8 LEU B  30
SER B  29
LEU B  12
ILE B  34
 None
 0.95A 3ln1A-2phcB:
undetectable		 3ln1A-2phcB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		4 / 8 ARG B  26
GLY B  83
THR B  85
ARG B  80
 None
 0.98A 4k87A-2phcB:
undetectable		 4k87A-2phcB:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		4 / 5 VAL B  54
LEU B  70
ILE B  13
LEU B  12
 None
 0.85A 4mghA-2phcB:
undetectable		 4mghA-2phcB:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		5 / 11 GLY B  97
GLY B  94
ILE B 100
GLY B 159
PHE B 216
 None
 1.15A 4qoiA-2phcB:
undetectable
4qoiB-2phcB:
undetectable		 4qoiA-2phcB:
22.99
4qoiB-2phcB:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		4 / 8 ILE B 185
LEU B 128
LEU B 201
ILE B 199
 None
 0.84A 4xtaB-2phcB:
undetectable		 4xtaB-2phcB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		4 / 8 ILE B 181
GLY B 159
THR B 189
LEU B 137
 None
 0.87A 5hs1A-2phcB:
undetectable		 5hs1A-2phcB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2phc UNCHARACTERIZED
PROTEIN PH0987
(Pyrococcus
horikoshii) 		3 / 3 GLY B  97
ASP B  99
ILE B 163
 None
 0.58A 6dgxB-2phcB:
undetectable		 6dgxB-2phcB:
17.92