SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2phk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 12 LEU A  25
GLY A  26
VAL A  33
ALA A  46
GLU A 110
ASN A 154
LEU A 156
THR A 166
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.3A)
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
MN  A 382 (-2.0A)
 0.70A 1fmoE-2phkA:
30.7		 1fmoE-2phkA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 12 LEU A  25
ALA A  46
LYS A  48
GLU A  73
LEU A 101
LEU A 105
GLY A 109
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.71A 1m17A-2phkA:
24.9		 1m17A-2phkA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
ALA A  46
LYS A  48
LEU A 105
MET A 106
GLY A 109
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.62A 1m17A-2phkA:
24.9		 1m17A-2phkA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A  25
LYS A  48
MET A 106
ARG A 148
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.2A)
None
None
 1.09A 1opjB-2phkA:
21.7		 1opjB-2phkA:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		3 / 3 VAL A 217
VAL A 264
TRP A 213
 None
 0.88A 1w5uA-2phkA:
undetectable
1w5uB-2phkA:
undetectable		 1w5uA-2phkA:
4.42
1w5uB-2phkA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 9 LEU A  25
VAL A  33
ALA A  46
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
 0.45A 1xbbA-2phkA:
25.7		 1xbbA-2phkA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 ALA A  46
GLY A 109
ASP A 113
LEU A 156
THR A 166
PHE A 168
 ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
None
 0.87A 1xkkA-2phkA:
21.9		 1xkkA-2phkA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 GLY A 109
ASP A 113
LEU A 156
THR A 166
ASP A 167
PHE A 168
 None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
MN  A 382 (-2.0A)
None
 1.02A 1xkkA-2phkA:
21.9		 1xkkA-2phkA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 9 LEU A  25
VAL A  33
LEU A  89
LEU A 101
LEU A 105
MET A 106
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
None
None
None
None
 0.56A 1xkkA-2phkA:
21.9		 1xkkA-2phkA:
26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 VAL A  33
LYS A  48
PHE A 103
ASN A 154
LEU A 156
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.59A 2eufB-2phkA:
22.0		 2eufB-2phkA:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
GLY A  26
VAL A  33
ALA A  46
ASP A 149
LYS A 151
ASN A 154
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 ( 4.5A)
ATP  A 381 (-3.2A)
MN  A 383 ( 2.7A)
 0.65A 2fumA-2phkA:
27.9		 2fumA-2phkA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
GLY A  26
GLY A  28
VAL A  33
ALA A  46
LYS A 151
ASN A 154
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
MN  A 383 ( 2.7A)
 0.62A 2fumD-2phkA:
26.7		 2fumD-2phkA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
ALA A  46
LYS A  48
LEU A 101
GLY A 109
ASP A 113
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.83A 2itoA-2phkA:
23.6		 2itoA-2phkA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
VAL A  33
ALA A  46
GLY A 109
ASP A 113
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.72A 2itzA-2phkA:
23.3		 2itzA-2phkA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
GLY A 109
THR A 166
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.6A)
MN  A 382 (-2.0A)
 0.79A 2itzA-2phkA:
23.3		 2itzA-2phkA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLY A 109
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.68A 2itzA-2phkA:
23.3		 2itzA-2phkA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		3 / 3 LEU A 101
LEU A 105
MET A 106
 None
 0.63A 2itzA-2phkA:
23.3		 2itzA-2phkA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
GLY A  26
VAL A  33
LEU A  77
LEU A 101
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
None
None
ATP  A 381 ( 4.8A)
 0.46A 2ivuA-2phkA:
26.1		 2ivuA-2phkA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
GLY A  26
VAL A  33
LYS A  48
LEU A  77
LEU A 101
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
 0.47A 2ivuA-2phkA:
26.1		 2ivuA-2phkA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		3 / 3 VAL A 264
TRP A 213
VAL A 217
 None
 0.83A 2izqC-2phkA:
undetectable
2izqD-2phkA:
undetectable		 2izqC-2phkA:
4.42
2izqD-2phkA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A 140
VAL A  80
LYS A  79
ILE A  86
 None
 0.75A 2piwA-2phkA:
undetectable		 2piwA-2phkA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 GLY A  26
VAL A  33
ALA A  46
MET A 106
GLY A 109
ASP A 167
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
MN  A 382 (-2.0A)
 0.73A 2wgjA-2phkA:
22.6		 2wgjA-2phkA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 9 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.65A 2xp2A-2phkA:
23.0		 2xp2A-2phkA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 12 VAL A  33
ALA A  46
ILE A  87
PHE A 103
LEU A 105
MET A 106
GLY A 109
GLU A 110
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
None
ATP  A 381 (-3.3A)
ATP  A 381 ( 4.8A)
 0.34A 2y7jA-2phkA:
38.0		 2y7jA-2phkA:
53.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 10 VAL A  33
ALA A  46
ILE A  87
PHE A 103
LEU A 105
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
None
ATP  A 381 ( 4.8A)
 0.28A 2y7jB-2phkA:
38.1		 2y7jB-2phkA:
53.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 10 VAL A  33
ALA A  46
ILE A  87
PHE A 103
LEU A 105
MET A 106
GLY A 109
ASP A 113
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
None
None
ATP  A 381 ( 4.8A)
 0.44A 2y7jC-2phkA:
38.0		 2y7jC-2phkA:
53.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 10 VAL A  33
ALA A  46
ILE A  87
PHE A 103
LEU A 105
MET A 106
GLY A 109
ASP A 113
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
None
None
ATP  A 381 ( 4.8A)
 0.48A 2y7jD-2phkA:
37.7		 2y7jD-2phkA:
53.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 8 LEU A  25
ALA A  46
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.62A 2yfxA-2phkA:
22.6		 2yfxA-2phkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 10 LEU A  25
ALA A  46
LEU A 105
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
None
None
None
ATP  A 381 ( 4.8A)
 0.44A 3aoxA-2phkA:
22.2		 3aoxA-2phkA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 VAL A  33
ALA A  46
LEU A  89
LEU A 105
GLY A 109
LEU A 156
THR A 166
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.39A 3bbtB-2phkA:
21.7		 3bbtB-2phkA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 VAL A  33
ALA A  46
LEU A 105
GLY A 109
LEU A 156
THR A 166
PHE A 168
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
None
 0.80A 3bbtB-2phkA:
21.7		 3bbtB-2phkA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A  25
VAL A  33
LYS A  48
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
ATP  A 381 ( 4.8A)
 0.81A 3cs9D-2phkA:
21.0		 3cs9D-2phkA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
GLY A  26
GLY A  28
VAL A  33
ALA A  46
LYS A  48
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
ATP  A 381 ( 4.8A)
 0.43A 3fupB-2phkA:
26.3		 3fupB-2phkA:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 VAL A  33
ALA A  46
GLU A  73
LEU A  77
ILE A  87
HIS A 147
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
 0.83A 3gp0A-2phkA:
22.8		 3gp0A-2phkA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 7 LYS A  48
LEU A 101
LEU A 105
MET A 106
ILE A  86
 ATP  A 381 (-3.2A)
None
None
None
None
 1.45A 3gp0A-2phkA:
22.8		 3gp0A-2phkA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 12 ALA A  46
LEU A  77
ILE A  87
LEU A 105
ASP A 167
 ATP  A 381 (-3.5A)
None
None
None
MN  A 382 (-2.0A)
 1.04A 3hecA-2phkA:
22.2		 3hecA-2phkA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 12 VAL A  33
ALA A  46
LYS A  48
LEU A  77
ILE A  87
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.81A 3hegA-2phkA:
21.8		 3hegA-2phkA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 7 LEU A  25
LYS A  48
MET A 106
ARG A 148
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.2A)
None
None
 1.22A 3ik3A-2phkA:
22.0		 3ik3A-2phkA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 7 LEU A  25
LYS A  48
MET A 106
ARG A 148
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.2A)
None
None
 1.20A 3ik3B-2phkA:
21.7		 3ik3B-2phkA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
GLY A  26
VAL A  33
ALA A  46
LYS A  48
ILE A  87
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
ATP  A 381 ( 4.8A)
 0.53A 3lxnA-2phkA:
26.0		 3lxnA-2phkA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 9 ALA A  46
PHE A 103
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 (-3.5A)
None
None
None
ATP  A 381 ( 4.8A)
 0.59A 3miyB-2phkA:
23.1		 3miyB-2phkA:
26.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 GLY A  26
VAL A  33
ALA A  46
LYS A  48
LEU A  77
ILE A  87
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.69A 3ohtA-2phkA:
17.4		 3ohtA-2phkA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 GLY A  26
VAL A  33
ALA A  46
LYS A  48
ILE A  87
GLY A 109
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.87A 3ohtB-2phkA:
18.1		 3ohtB-2phkA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 GLY A  26
VAL A  33
LYS A  48
LEU A  77
ILE A  87
GLY A 109
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
None
 0.93A 3ohtB-2phkA:
18.1		 3ohtB-2phkA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 9 LEU A  25
LYS A  48
MET A 106
ARG A 148
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 1.01A 3oxzA-2phkA:
21.8		 3oxzA-2phkA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 7 ILE A  86
SER A 171
VAL A 210
SER A 214
 None
 0.93A 3r9vA-2phkA:
2.6
3r9vB-2phkA:
undetectable		 3r9vA-2phkA:
20.00
3r9vB-2phkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 VAL A  33
ALA A  46
GLU A  73
LEU A  77
ILE A  87
PHE A 103
LEU A 140
HIS A 147
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
None
None
 0.78A 3rgfA-2phkA:
23.1		 3rgfA-2phkA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 5 VAL A  32
VAL A  33
ARG A  34
LYS A 107
 None
ATP  A 381 (-4.1A)
None
None
 1.47A 3rv5A-2phkA:
0.0
3rv5B-2phkA:
0.0		 3rv5A-2phkA:
15.05
3rv5B-2phkA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
ALA A  46
LYS A  48
GLU A  73
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
 0.61A 3ue4A-2phkA:
25.3		 3ue4A-2phkA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		10 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
LEU A 101
LEU A 105
MET A 106
GLY A 109
ASP A 113
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
None
ATP  A 381 ( 4.8A)
 0.86A 3ug2A-2phkA:
23.8		 3ug2A-2phkA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 8 VAL A  33
LYS A  48
ILE A  87
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
MN  A 382 (-2.0A)
 0.57A 3warA-2phkA:
26.4		 3warA-2phkA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
LEU A  77
GLY A 109
HIS A 147
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
 0.51A 3wzeA-2phkA:
22.4		 3wzeA-2phkA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 ALA A  46
LEU A 105
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 (-3.5A)
None
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.58A 3zbfA-2phkA:
24.3		 3zbfA-2phkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
ALA A  46
LEU A 105
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.73A 3zbfA-2phkA:
24.3		 3zbfA-2phkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 0.69A 4ag8A-2phkA:
22.1		 4ag8A-2phkA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
VAL A  33
ALA A  46
LEU A  77
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.47A 4agcA-2phkA:
21.8		 4agcA-2phkA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
VAL A  33
LYS A  48
LEU A  77
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 0.52A 4agcA-2phkA:
21.8		 4agcA-2phkA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 9 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.68A 4anqA-2phkA:
22.7		 4anqA-2phkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 9 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.72A 4ansA-2phkA:
22.6		 4ansA-2phkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A  77
GLY A 109
HIS A 147
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
 0.69A 4asdA-2phkA:
21.9		 4asdA-2phkA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 8 TRP A 213
VAL A 217
TYR A 246
ILE A 241
 None
 1.33A 4bqtC-2phkA:
undetectable
4bqtD-2phkA:
undetectable		 4bqtC-2phkA:
23.34
4bqtD-2phkA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 ALA A  46
LYS A  48
GLU A  73
LEU A  77
ILE A  86
HIS A 147
LEU A 156
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
ATP  A 381 ( 4.8A)
 0.80A 4c8bB-2phkA:
23.9		 4c8bB-2phkA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 11 LEU A  25
GLY A  26
VAL A  33
ALA A  46
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
 0.50A 4ckiA-2phkA:
25.9		 4ckiA-2phkA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 10 LEU A  25
GLY A  26
GLY A  28
VAL A  33
ALA A  46
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 ( 4.8A)
 0.58A 4ckjA-2phkA:
26.0		 4ckjA-2phkA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.49A 4hjoA-2phkA:
23.0		 4hjoA-2phkA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 12 LEU A  25
GLY A  26
VAL A  33
ALA A  46
GLY A 109
ASP A 113
LEU A 156
THR A 166
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
MN  A 382 (-2.0A)
 0.72A 4i22A-2phkA:
21.8		 4i22A-2phkA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 12 LEU A  25
GLY A  26
VAL A  33
ALA A  46
LEU A 101
GLY A 109
ASP A 113
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.67A 4i22A-2phkA:
21.8		 4i22A-2phkA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 12 LEU A  25
GLY A  26
VAL A  33
ALA A  46
LYS A  48
GLY A 109
LEU A 156
THR A 166
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
MN  A 382 (-2.0A)
 0.79A 4i22A-2phkA:
21.8		 4i22A-2phkA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 12 LEU A  25
GLY A  26
VAL A  33
ALA A  46
LYS A  48
LEU A 101
GLY A 109
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.67A 4i22A-2phkA:
21.8		 4i22A-2phkA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 VAL A  33
ALA A  46
ILE A  87
ASP A 113
ASP A 149
ASN A 154
LEU A 156
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.5A)
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.79A 4i41A-2phkA:
28.9		 4i41A-2phkA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 VAL A  33
ALA A  46
ILE A  87
ASP A 113
ASP A 149
LYS A 151
ASN A 154
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.5A)
ATP  A 381 (-3.2A)
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
 0.79A 4i41A-2phkA:
28.9		 4i41A-2phkA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 11 VAL A  33
ALA A  46
LYS A  48
GLU A 153
LEU A 156
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.95A 4iaaA-2phkA:
28.6		 4iaaA-2phkA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 7 VAL A  33
ALA A  46
MET A 106
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
 0.73A 4l9iA-2phkA:
23.0		 4l9iA-2phkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 8 GLY A  28
VAL A  33
ALA A  46
LYS A  48
LEU A 156
 ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
ATP  A 381 ( 4.8A)
 0.71A 4l9iB-2phkA:
27.0		 4l9iB-2phkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 8 GLY A  28
VAL A  33
ALA A  46
MET A 106
LEU A 156
 ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
 0.84A 4l9iB-2phkA:
27.0		 4l9iB-2phkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
VAL A  33
ALA A  46
LEU A 105
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.54A 4mkcA-2phkA:
23.1		 4mkcA-2phkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 0.83A 4mxxB-2phkA:
16.4		 4mxxB-2phkA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 6 LEU A  25
GLY A  26
VAL A  33
ALA A  46
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 ( 4.8A)
 0.38A 4o0wA-2phkA:
23.4		 4o0wA-2phkA:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 7 GLY A  26
ALA A  46
ASN A 154
LEU A 156
ASP A 167
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.5A)
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.83A 4ogrE-2phkA:
26.9		 4ogrE-2phkA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
GLY A  26
GLY A  28
VAL A  33
ALA A  46
LYS A  48
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
ATP  A 381 ( 4.8A)
 0.56A 4otiA-2phkA:
23.7		 4otiA-2phkA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 8 LEU A  25
VAL A  33
ILE A  87
HIS A 147
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
None
None
ATP  A 381 ( 4.8A)
 0.70A 4qrcA-2phkA:
22.9		 4qrcA-2phkA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 8 LEU A  25
VAL A  33
LYS A  48
ILE A  87
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
ATP  A 381 ( 4.8A)
 0.81A 4qrcA-2phkA:
22.9		 4qrcA-2phkA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 10 ALA A  46
LYS A  48
ILE A  87
LEU A 105
LEU A 156
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 0.57A 4rz7A-2phkA:
24.0		 4rz7A-2phkA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.59A 4twpA-2phkA:
25.2		 4twpA-2phkA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
ASN A 154
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.55A 4twpA-2phkA:
25.2		 4twpA-2phkA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.65A 4twpB-2phkA:
19.5		 4twpB-2phkA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
ASN A 154
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.52A 4twpB-2phkA:
19.5		 4twpB-2phkA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A  25
VAL A  33
LYS A  48
ILE A  86
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
 0.70A 4tyjA-2phkA:
22.6		 4tyjA-2phkA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 ALA A  46
LYS A  48
LEU A  77
GLY A 109
HIS A 147
LEU A 156
ASP A 167
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.91A 4u0iA-2phkA:
22.6		 4u0iA-2phkA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 11 LEU A  25
GLY A  28
VAL A  33
ALA A  46
MET A 106
GLY A 109
ASN A 154
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.55A 4u5jA-2phkA:
18.6		 4u5jA-2phkA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 9 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.50A 4u5jB-2phkA:
18.5		 4u5jB-2phkA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 9 LEU A  25
VAL A  33
LYS A  48
ILE A  87
ARG A 148
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 1.05A 4v01A-2phkA:
21.6		 4v01A-2phkA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 10 LEU A  25
VAL A  33
LYS A  48
ILE A  87
ARG A 148
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 1.15A 4v04B-2phkA:
22.1		 4v04B-2phkA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 11 LEU A  25
ALA A  46
MET A 106
GLY A 109
ASN A 154
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
None
None
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
 0.77A 4wa9A-2phkA:
21.1		 4wa9A-2phkA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A  25
ALA A  46
MET A 106
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
 0.46A 4wboC-2phkA:
26.9		 4wboC-2phkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		10 / 12 LEU A  25
ALA A  46
LYS A  48
GLU A  73
LEU A 101
LEU A 105
GLY A 109
ASP A 113
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.73A 4wkqA-2phkA:
24.6		 4wkqA-2phkA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 12 SER A  30
LEU A  66
ALA A  69
LEU A  71
THR A  92
 None
 1.24A 4x1kA-2phkA:
undetectable
4x1kB-2phkA:
undetectable		 4x1kA-2phkA:
20.97
4x1kB-2phkA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 6 ALA A  46
LEU A 105
MET A 106
LEU A 156
 ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.25A 4xoyA-2phkA:
26.0		 4xoyA-2phkA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 6 ALA A  46
LEU A 105
MET A 106
LEU A 156
 ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.28A 4xp3A-2phkA:
26.4		 4xp3A-2phkA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 12 ALA A  46
LYS A  48
LEU A  77
ASP A 167
PHE A 168
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
MN  A 382 (-2.0A)
None
 0.92A 4xv2B-2phkA:
23.8		 4xv2B-2phkA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 9 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.66A 5aaaA-2phkA:
23.0		 5aaaA-2phkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 10 LEU A  25
VAL A  33
ALA A  46
LYS A  48
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.81A 5aabA-2phkA:
22.7		 5aabA-2phkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 10 LEU A  25
VAL A  33
ALA A  46
LYS A  48
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 0.64A 5aacA-2phkA:
22.6		 5aacA-2phkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 10 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.69A 5aacA-2phkA:
22.6		 5aacA-2phkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
ILE A  87
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
 0.61A 5bvwA-2phkA:
15.7		 5bvwA-2phkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 12 VAL A  33
ALA A  46
LYS A  48
LEU A  77
PHE A 168
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.86A 5cswB-2phkA:
23.3		 5cswB-2phkA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 6 TYR A 206
VAL A 210
PRO A 272
ALA A 191
 None
 0.90A 5cu6A-2phkA:
26.1		 5cu6A-2phkA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
VAL A  33
ALA A  46
LEU A 105
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.53A 5h2uA-2phkA:
22.4		 5h2uA-2phkA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
VAL A  33
ALA A  46
LEU A 105
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.60A 5h2uB-2phkA:
22.8		 5h2uB-2phkA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
VAL A  33
ALA A  46
LEU A 105
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.50A 5h2uD-2phkA:
22.7		 5h2uD-2phkA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 7 GLY A  26
GLY A  28
LYS A  48
GLU A 110
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.0A)
ATP  A 381 (-3.2A)
ATP  A 381 (-3.3A)
 0.82A 5izfA-2phkA:
23.7		 5izfA-2phkA:
29.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 11 LEU A  25
GLY A  26
VAL A  33
ALA A  46
GLU A 110
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.3A)
ATP  A 381 ( 4.8A)
 0.50A 5lvnA-2phkA:
32.0		 5lvnA-2phkA:
33.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  26
VAL A  33
ALA A  46
ILE A  87
MET A 106
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
 0.43A 5lw1B-2phkA:
23.0		 5lw1B-2phkA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 10 GLY A  26
VAL A  33
ALA A  46
ILE A  87
LEU A 105
MET A 106
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
 0.55A 5lw1E-2phkA:
22.8		 5lw1E-2phkA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A  26
VAL A  33
ALA A  46
LEU A 105
MET A 106
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
 0.48A 5lw1H-2phkA:
23.3		 5lw1H-2phkA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 GLU A  23
VAL A  33
ALA A  46
LYS A  48
GLU A  73
GLY A 109
GLU A 110
 None
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 (-3.3A)
 0.80A 5mafA-2phkA:
30.6		 5mafA-2phkA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 GLY A  26
VAL A  33
ALA A  46
LYS A  48
GLU A  73
GLY A 109
GLU A 110
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 (-3.3A)
 0.75A 5mafA-2phkA:
30.6		 5mafA-2phkA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 10 LEU A  25
VAL A  33
LYS A  48
MET A 106
GLY A 109
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
 0.61A 5mo4A-2phkA:
16.6		 5mo4A-2phkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 10 VAL A  33
LYS A  48
GLU A  73
MET A 106
GLY A 109
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
None
 0.62A 5mo4A-2phkA:
16.6		 5mo4A-2phkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 5 TYR A 206
VAL A 210
PRO A 272
ALA A 191
 None
 0.86A 5otrA-2phkA:
26.1		 5otrA-2phkA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 8 ALA A  46
GLU A  73
LEU A 156
ASP A 167
 ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.48A 5owrA-2phkA:
23.6		 5owrA-2phkA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 4 ARG A 148
GLN A 173
PHE A 170
LEU A 143
 None
 1.28A 5uhgC-2phkA:
0.0		 5uhgC-2phkA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 GLU A  23
ALA A  46
GLU A  73
GLY A 109
ASP A 113
ASP A 167
 None
ATP  A 381 (-3.5A)
None
None
None
MN  A 382 (-2.0A)
 1.12A 5vc3A-2phkA:
19.7		 5vc3A-2phkA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
ALA A  46
LYS A  48
GLU A  73
LEU A 101
GLY A 109
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
 1.08A 5vcvA-2phkA:
27.2		 5vcvA-2phkA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A 101
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.61A 5vcyA-2phkA:
27.1		 5vcyA-2phkA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A  25
GLY A  26
VAL A  33
ALA A  46
PHE A 103
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
 0.29A 5xv7A-2phkA:
25.8		 5xv7A-2phkA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A 105
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
 0.65A 5y7zA-2phkA:
27.7		 5y7zA-2phkA:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A 105
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
 0.65A 5y7zA-2phkA:
27.7		 5y7zA-2phkA:
30.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 LEU A  25
ALA A  46
LYS A  48
GLU A  73
LEU A 105
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.69A 5y7zB-2phkA:
27.8		 5y7zB-2phkA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		9 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A 105
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.64A 5y80A-2phkA:
27.1		 5y80A-2phkA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 8 VAL A  33
LYS A  48
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
MN  A 382 (-2.0A)
 0.42A 5y9mA-2phkA:
25.6		 5y9mA-2phkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 8 VAL A  33
LYS A  48
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
MN  A 382 (-2.0A)
 0.41A 5y9mX-2phkA:
25.7		 5y9mX-2phkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		4 / 7 VAL A  33
LYS A  48
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
MN  A 382 (-2.0A)
 0.58A 5yf9B-2phkA:
25.3		 5yf9B-2phkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 9 VAL A  33
LYS A  48
ILE A  87
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
MN  A 382 (-2.0A)
 0.61A 5yf9X-2phkA:
25.9		 5yf9X-2phkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 LEU A  25
GLY A  26
VAL A  33
ALA A  46
LEU A 101
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.70A 5yu9A-2phkA:
21.8		 5yu9A-2phkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		7 / 12 GLY A  26
VAL A  33
ALA A  46
LEU A 101
ASP A 113
LEU A 156
THR A 166
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.86A 5yu9B-2phkA:
21.9		 5yu9B-2phkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 VAL A  33
ALA A  46
LEU A 101
GLY A 109
ASP A 113
THR A 166
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
ATP  A 381 ( 4.6A)
 0.71A 5yu9C-2phkA:
21.6		 5yu9C-2phkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 12 VAL A  33
ALA A  46
GLY A 109
LEU A 156
THR A 166
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.44A 5yu9D-2phkA:
22.1		 5yu9D-2phkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		5 / 7 VAL A  33
LYS A  48
ILE A  87
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
MN  A 382 (-2.0A)
 0.49A 5ywmX-2phkA:
25.7		 5ywmX-2phkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
GLY A 109
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.65A 5zv2B-2phkA:
22.2		 5zv2B-2phkA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2phk PHOSPHORYLASE KINASE
(Oryctolagus
cuniculus) 		8 / 12 VAL A  33
ALA A  46
LYS A  48
GLU A  73
ILE A  87
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
ATP  A 381 ( 4.8A)
 0.49A 6bsdA-2phkA:
22.0		 6bsdA-2phkA:
14.17