SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2php'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2php UNCHARACTERIZED
PROTEIN MJ0236
(Methanocaldococc
us
jannaschii) 		4 / 4 GLY A 400
ASP A 382
GLY A 379
THR A 370
 None
 1.08A 1hxbB-2phpA:
undetectable		 1hxbB-2phpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2php UNCHARACTERIZED
PROTEIN MJ0236
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 356
ILE A 318
PHE A 354
GLU A 367
 None
 1.21A 1nsiC-2phpA:
undetectable
1nsiD-2phpA:
undetectable		 1nsiC-2phpA:
18.78
1nsiD-2phpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2php UNCHARACTERIZED
PROTEIN MJ0236
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 320
ILE A 315
SER A 312
GLY A 310
 None
None
CL  A   6 (-2.9A)
None
 0.97A 2otfA-2phpA:
undetectable		 2otfA-2phpA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 2php UNCHARACTERIZED
PROTEIN MJ0236
(Methanocaldococc
us
jannaschii) 		4 / 5 ASP A 402
ARG A 330
ARG A 401
ILE A 242
 None
 1.40A 3sanA-2phpA:
undetectable		 3sanA-2phpA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 2php UNCHARACTERIZED
PROTEIN MJ0236
(Methanocaldococc
us
jannaschii) 		4 / 5 ASP A 402
ARG A 330
ARG A 401
ILE A 242
 None
 1.40A 3sanB-2phpA:
undetectable		 3sanB-2phpA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2php UNCHARACTERIZED
PROTEIN MJ0236
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 354
GLU A 367
ARG A 356
ILE A 318
 None
 1.24A 4nosA-2phpA:
undetectable
4nosB-2phpA:
undetectable		 4nosA-2phpA:
18.66
4nosB-2phpA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2php UNCHARACTERIZED
PROTEIN MJ0236
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 356
ILE A 318
PHE A 354
GLU A 367
 None
 1.26A 4nosC-2phpA:
undetectable
4nosD-2phpA:
undetectable		 4nosC-2phpA:
18.66
4nosD-2phpA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2php UNCHARACTERIZED
PROTEIN MJ0236
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 354
GLU A 367
ARG A 356
ILE A 318
 None
 1.30A 4nosC-2phpA:
undetectable
4nosD-2phpA:
undetectable		 4nosC-2phpA:
18.66
4nosD-2phpA:
18.66