SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pi2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F4D_A_CHDA505_0 (FERROCHELATASE, MITOCHONDRIAL)	2pi2	REPLICATION PROTEIN A 14 KDA SUBUNIT (Homo sapiens)	4 / 7	MET E 16 ILE E 106 ARG E 11 VAL E 28	None	1.44A	4f4dA-2pi2E: undetectable	4f4dA-2pi2E: 15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MK4_B_CHDB502_0 (FERROCHELATASE, MITOCHONDRIAL)	2pi2	REPLICATION PROTEIN A 14 KDA SUBUNIT (Homo sapiens)	4 / 6	MET E 16 ILE E 106 ARG E 11 VAL E 28	None	1.41A	4mk4B-2pi2E: undetectable	4mk4B-2pi2E: 15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O8F_A_BRLA501_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2pi2	REPLICATION PROTEIN A 14 KDA SUBUNIT (Homo sapiens)	4 / 5	GLY E 71 LEU E 17 ILE E 53 LEU E 115	None	0.79A	4o8fA-2pi2E: undetectable	4o8fA-2pi2E: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZNI_A_YMZA302_0 (PURINE NUCLEOSIDE PHOSPHORYLASE)	2pi2	REPLICATION PROTEIN A 14 KDA SUBUNIT (Homo sapiens)	5 / 9	VAL E 25 GLY E 29 VAL E 67 GLU E 68 ASP E 45	None	1.19A	5zniA-2pi2E: undetectable	5zniA-2pi2E: 19.86

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4F4D_A_CHDA505_0","FERROCHELATASE, MITOCHONDRIAL","2pi2","REPLICATION PROTEIN A 14 KDA SUBUNIT","Homo sapiens",4,"MET E  16;ILE E 106;ARG E  11;VAL E  28","None","1.44A","4f4dA-2pi2E:undetectable","4f4dA-2pi2E:15.30"],["4MK4_B_CHDB502_0","FERROCHELATASE, MITOCHONDRIAL","2pi2","REPLICATION PROTEIN A 14 KDA SUBUNIT","Homo sapiens",4,"MET E  16;ILE E 106;ARG E  11;VAL E  28","None","1.41A","4mk4B-2pi2E:undetectable","4mk4B-2pi2E:15.57"],["4O8F_A_BRLA501_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","2pi2","REPLICATION PROTEIN A 14 KDA SUBUNIT","Homo sapiens",4,"GLY E  71;LEU E  17;ILE E  53;LEU E 115","None","0.79A","4o8fA-2pi2E:undetectable","4o8fA-2pi2E:19.33"],["5ZNI_A_YMZA302_0","PURINE NUCLEOSIDE PHOSPHORYLASE","2pi2","REPLICATION PROTEIN A 14 KDA SUBUNIT","Homo sapiens",5,"VAL E  25;GLY E  29;VAL E  67;GLU E  68;ASP E  45","None","1.19A","5zniA-2pi2E:undetectable","5zniA-2pi2E:19.86"]]