SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 VAL A 735
VAL A 725
TRP A 422
 None
 0.83A 1av2A-2pi5A:
undetectable
1av2B-2pi5A:
undetectable		 1av2A-2pi5A:
2.26
1av2B-2pi5A:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 8 ALA A 338
LEU A 443
LEU A 402
ALA A 405
 None
 0.74A 1e7cA-2pi5A:
3.8		 1e7cA-2pi5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 VAL A 473
TYR A 518
ILE A 462
GLY A 464
ALA A 465
 None
 1.03A 1eqhA-2pi5A:
2.1		 1eqhA-2pi5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 11 SER A 223
PHE A  89
LEU A 106
VAL A 212
VAL A 114
 None
 1.38A 1q23I-2pi5A:
undetectable		 1q23I-2pi5A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 LEU A 757
LEU A 749
ILE A 244
THR A 122
ILE A 761
 None
 0.93A 1tw4A-2pi5A:
undetectable		 1tw4A-2pi5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 LEU A 757
LEU A 749
ILE A 244
THR A 122
ILE A 761
 None
 0.91A 1tw4B-2pi5A:
undetectable		 1tw4B-2pi5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 VAL A 735
VAL A 725
TRP A 422
 None
 0.78A 1w5uA-2pi5A:
undetectable
1w5uB-2pi5A:
undetectable		 1w5uA-2pi5A:
2.26
1w5uB-2pi5A:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 ARG A 829
PHE A 882
ASP A 812
SER A 547
ILE A 543
 None
 1.48A 1ynnC-2pi5A:
0.0		 1ynnC-2pi5A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 8 VAL A 134
THR A 760
PRO A 759
LEU A 757
 None
 0.85A 1z2bB-2pi5A:
undetectable		 1z2bB-2pi5A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 10 LEU A 512
PHE A 509
LEU A 497
ILE A 341
ALA A 336
 None
 1.14A 2bxeB-2pi5A:
3.8		 2bxeB-2pi5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 11 ARG A 394
LEU A 398
LEU A 335
GLY A 442
LYS A 441
 None
 1.22A 2bxmA-2pi5A:
2.4		 2bxmA-2pi5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 7 THR A 630
LEU A 582
VAL A 578
VAL A 650
 None
 1.03A 2cppA-2pi5A:
undetectable		 2cppA-2pi5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 PHE A 733
TYR A 308
SER A 301
ALA A 304
ALA A 200
 None
 1.25A 2igtC-2pi5A:
undetectable		 2igtC-2pi5A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 VAL A 725
TRP A 422
VAL A 735
 None
 0.80A 2izqC-2pi5A:
undetectable
2izqD-2pi5A:
undetectable		 2izqC-2pi5A:
2.26
2izqD-2pi5A:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 THR A 282
ASP A 147
SER A  43
 None
 0.78A 2nxeA-2pi5A:
undetectable		 2nxeA-2pi5A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 THR A 282
ASP A 147
SER A  43
 None
 0.76A 2nxeB-2pi5A:
undetectable		 2nxeB-2pi5A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 VAL A 828
ALA A 798
LEU A 809
PHE A 814
SER A 813
 None
 1.09A 2oipA-2pi5A:
undetectable		 2oipA-2pi5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 VAL A 828
ALA A 798
LEU A 809
PHE A 814
SER A 813
 None
 1.03A 2oipC-2pi5A:
undetectable		 2oipC-2pi5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 4 VAL A 629
THR A 630
VAL A 574
GLY A 572
 None
 1.16A 2p2fB-2pi5A:
undetectable		 2p2fB-2pi5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 10 PHE A 667
THR A 654
VAL A 625
ILE A 655
VAL A 650
 None
 1.13A 2qboA-2pi5A:
undetectable		 2qboA-2pi5A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 7 ILE A  74
MET A  81
LEU A 220
LEU A 123
 None
 1.04A 2qqcB-2pi5A:
undetectable
2qqcC-2pi5A:
undetectable		 2qqcB-2pi5A:
8.93
2qqcC-2pi5A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 ILE A 117
ILE A 145
ILE A 141
ILE A  82
VAL A 227
 None
 1.00A 2ygoA-2pi5A:
undetectable		 2ygoA-2pi5A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 PRO A 734
GLU A 309
TYR A 308
 None
 0.78A 2zmbA-2pi5A:
undetectable		 2zmbA-2pi5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 4 GLU A 242
ARG A 231
ASN A 233
ASP A 240
 None
 1.24A 2zq9A-2pi5A:
undetectable		 2zq9A-2pi5A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 5 VAL A 137
VAL A 134
THR A 118
THR A 132
 None
 0.99A 3bjwA-2pi5A:
undetectable		 3bjwA-2pi5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 5 VAL A 137
VAL A 134
THR A 118
THR A 132
 None
 1.10A 3bjwG-2pi5A:
undetectable		 3bjwG-2pi5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 5 VAL A 137
VAL A 134
THR A 118
THR A 132
 None
 1.01A 3bjwD-2pi5A:
undetectable		 3bjwD-2pi5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 VAL A 214
GLY A 213
GLY A 142
VAL A 137
ALA A 102
 None
 1.30A 3dh0A-2pi5A:
undetectable		 3dh0A-2pi5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 6 ILE A 810
THR A 440
PHE A 432
PHE A 416
 None
 1.14A 3elzB-2pi5A:
undetectable		 3elzB-2pi5A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 VAL A 828
ALA A 798
LEU A 809
PHE A 814
SER A 813
 None
 0.96A 3hj3C-2pi5A:
undetectable		 3hj3C-2pi5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 VAL A 828
ALA A 798
LEU A 809
PHE A 814
SER A 813
 None
 1.02A 3hj3D-2pi5A:
undetectable		 3hj3D-2pi5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 SER A 209
GLY A 142
SER A 202
 None
 0.68A 3loqA-2pi5A:
undetectable		 3loqA-2pi5A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 11 ILE A 681
ALA A 575
ILE A 543
LEU A 637
VAL A 685
 None
 1.12A 3n0hA-2pi5A:
undetectable		 3n0hA-2pi5A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 GLY A 259
ASN A 339
PRO A  72
LEU A 402
LEU A 261
 None
 1.15A 3p2kB-2pi5A:
undetectable		 3p2kB-2pi5A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 ILE A 681
ALA A 575
ILE A 543
LEU A 637
VAL A 685
 None
 1.08A 3s3vA-2pi5A:
undetectable		 3s3vA-2pi5A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 8 LEU A 561
MET A 832
TYR A 836
HIS A 545
 None
 1.32A 3zmdA-2pi5A:
4.8
3zmdB-2pi5A:
5.4		 3zmdA-2pi5A:
13.03
3zmdB-2pi5A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 7 ARG A 423
VAL A 728
TRP A 727
PHE A 733
 None
 1.43A 4jseA-2pi5A:
undetectable
4jseB-2pi5A:
undetectable		 4jseA-2pi5A:
18.98
4jseB-2pi5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 7 PHE A 733
ARG A 423
VAL A 728
TRP A 727
 None
 1.47A 4jseA-2pi5A:
undetectable
4jseB-2pi5A:
undetectable		 4jseA-2pi5A:
18.98
4jseB-2pi5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 8 THR A 630
LEU A 582
VAL A 578
VAL A 650
 None
 1.01A 4l4dA-2pi5A:
undetectable		 4l4dA-2pi5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 8 THR A 630
LEU A 582
VAL A 578
VAL A 650
 None
 1.02A 4l4eA-2pi5A:
undetectable		 4l4eA-2pi5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 8 THR A 630
LEU A 582
VAL A 578
VAL A 650
 None
 1.02A 4l4fA-2pi5A:
undetectable		 4l4fA-2pi5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 ILE A 573
ILE A 681
LEU A 637
VAL A 693
ILE A 570
 None
 1.08A 4m2xG-2pi5A:
undetectable		 4m2xG-2pi5A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 5 LEU A 791
GLY A 788
ILE A 320
LYS A 318
 None
 1.17A 4ma8C-2pi5A:
3.5		 4ma8C-2pi5A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 7 ILE A 221
PHE A 751
VAL A 227
ILE A 244
 None
 0.81A 4zzbC-2pi5A:
undetectable
4zzbD-2pi5A:
undetectable		 4zzbC-2pi5A:
16.88
4zzbD-2pi5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 ILE A 221
VAL A 137
VAL A 134
PHE A 751
THR A 118
 None
 1.32A 5bykA-2pi5A:
undetectable		 5bykA-2pi5A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 GLU A 112
ILE A 244
GLY A 225
LEU A  77
MET A  81
 None
 1.19A 5esgA-2pi5A:
undetectable		 5esgA-2pi5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 PRO A 417
ILE A  19
SER A 430
 None
 0.60A 5fsaA-2pi5A:
2.1		 5fsaA-2pi5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 11 GLN A  36
VAL A 429
SER A 430
TYR A 286
LEU A 294
 None
 1.23A 5jh7B-2pi5A:
undetectable		 5jh7B-2pi5A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 11 GLN A  36
VAL A 429
SER A 430
TYR A 286
LEU A 294
 None
 1.28A 5jh7D-2pi5A:
undetectable		 5jh7D-2pi5A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 ASP A 770
ASN A 762
GLN A 744
 None
 0.70A 5k7uA-2pi5A:
undetectable		 5k7uA-2pi5A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 THR A 121
THR A 118
SER A 139
GLY A 142
ALA A 144
 None
 1.34A 5l5zV-2pi5A:
undetectable
5l5zb-2pi5A:
undetectable		 5l5zV-2pi5A:
13.44
5l5zb-2pi5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 THR A 121
ARG A 143
SER A 139
GLY A 142
ALA A 144
 None
 1.38A 5lf3b-2pi5A:
undetectable		 5lf3b-2pi5A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 THR A 121
THR A 118
SER A 139
GLY A 142
ALA A 144
 None
 1.33A 5lf3b-2pi5A:
undetectable		 5lf3b-2pi5A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 THR A 121
ARG A 143
SER A 139
GLY A 142
ALA A 144
 None
 1.38A 5lf3N-2pi5A:
undetectable		 5lf3N-2pi5A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 THR A 121
THR A 118
SER A 139
GLY A 142
ALA A 144
 None
 1.33A 5lf3N-2pi5A:
undetectable		 5lf3N-2pi5A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 7 GLY A 152
GLU A 148
LYS A 110
ALA A 113
 None
 0.96A 5mvsA-2pi5A:
undetectable		 5mvsA-2pi5A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 4 ASN A 579
SER A 628
ALA A 575
VAL A 574
 None
 1.08A 5nm5A-2pi5A:
undetectable		 5nm5A-2pi5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 ARG A 357
PRO A 248
TYR A 385
 None
 0.72A 5tzoB-2pi5A:
undetectable		 5tzoB-2pi5A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		5 / 12 GLY A 152
HIS A 161
GLU A 158
ASP A  13
ILE A  14
 None
 0.94A 5wz1A-2pi5A:
undetectable		 5wz1A-2pi5A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 7 ALA A 138
PHE A  89
PHE A 751
ILE A 109
 None
 0.88A 6b5vA-2pi5A:
undetectable
6b5vB-2pi5A:
undetectable		 6b5vA-2pi5A:
7.64
6b5vB-2pi5A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		3 / 3 PHE A 268
ARG A 143
ALA A 295
 None
 0.93A 6ecfB-2pi5A:
undetectable		 6ecfB-2pi5A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2pi5 DNA-DIRECTED RNA
POLYMERASE
(Escherichia
virus
T7) 		4 / 8 ASP A 421
ARG A 425
ARG A 792
VAL A 311
 None
 1.18A 6fbvD-2pi5A:
undetectable		 6fbvD-2pi5A:
21.64