SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pia'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 7 GLY A 122
ALA A 154
THR A 147
ILE A 121
 None
None
None
FMN  A 322 (-4.2A)
 0.79A 1gtnA-2piaA:
undetectable
1gtnK-2piaA:
undetectable		 1gtnA-2piaA:
12.10
1gtnK-2piaA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 8 GLY A 122
ALA A 154
THR A 147
ILE A 121
 None
None
None
FMN  A 322 (-4.2A)
 0.77A 1gtnP-2piaA:
undetectable
1gtnQ-2piaA:
undetectable		 1gtnP-2piaA:
12.10
1gtnQ-2piaA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		5 / 12 ILE A  23
THR A  90
VAL A  49
LEU A  28
ILE A  71
 None
 1.34A 1kqwA-2piaA:
undetectable		 1kqwA-2piaA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 8 LEU A 143
ILE A 170
GLY A 119
PHE A 183
 None
 0.84A 1sv9A-2piaA:
undetectable		 1sv9A-2piaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 8 ARG A 209
PRO A 125
SER A  58
GLY A 200
 None
None
FMN  A 322 (-3.4A)
None
 1.06A 2qd5B-2piaA:
undetectable		 2qd5B-2piaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 8 ILE A 305
PHE A 238
LEU A 261
VAL A 260
 None
 0.86A 2w98B-2piaA:
2.7		 2w98B-2piaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 8 ASP A 290
SER A 310
ASP A 293
ASP A 298
 None
 1.18A 3havA-2piaA:
undetectable		 3havA-2piaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		5 / 12 ARG A 262
ARG A 267
GLU A   5
ALA A  48
GLU A  97
 None
 1.48A 3k39A-2piaA:
undetectable		 3k39A-2piaA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		5 / 12 ARG A 262
ARG A 267
GLU A   5
ALA A  48
GLU A  97
 None
 1.49A 3k39H-2piaA:
undetectable		 3k39H-2piaA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		5 / 12 ARG A 262
ARG A 267
GLU A   5
ALA A  48
GLU A  97
 None
 1.49A 3k39I-2piaA:
undetectable		 3k39I-2piaA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		5 / 12 ARG A 262
ARG A 267
GLU A   5
ALA A  48
GLU A  97
 None
 1.47A 3k39L-2piaA:
undetectable		 3k39L-2piaA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_A_LLTA261_1
(DEOXYCYTIDINE KINASE)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		5 / 10 GLU A 136
ARG A 139
PHE A 114
LEU A 116
GLU A  40
 None
 0.91A 3qeoA-2piaA:
0.0		 3qeoA-2piaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 4 SER A 224
ASP A 293
ASP A 290
ALA A 227
 None
 1.29A 3uj6A-2piaA:
3.1		 3uj6A-2piaA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 6 ARG A 292
HIS A 291
LEU A 317
ASP A 290
 None
 1.27A 4cevD-2piaA:
2.8
4cevE-2piaA:
2.8		 4cevD-2piaA:
21.37
4cevE-2piaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 6 ARG A 292
HIS A 291
LEU A 317
ASP A 290
 None
 1.29A 4cevE-2piaA:
undetectable
4cevF-2piaA:
undetectable		 4cevE-2piaA:
21.37
4cevF-2piaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 7 LEU A 319
LEU A 321
SER A 245
THR A 247
 None
 0.96A 4ikjA-2piaA:
undetectable
4ikjB-2piaA:
undetectable		 4ikjA-2piaA:
18.04
4ikjB-2piaA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 8 LEU A 319
LEU A 321
SER A 245
THR A 247
 None
 0.98A 4ikjA-2piaA:
undetectable
4ikjB-2piaA:
undetectable		 4ikjA-2piaA:
18.04
4ikjB-2piaA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 8 SER A  63
SER A 128
ALA A 135
LEU A 133
 None
 0.96A 4ikjA-2piaA:
undetectable
4ikjB-2piaA:
undetectable		 4ikjA-2piaA:
18.04
4ikjB-2piaA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 8 ALA A 135
LEU A 133
SER A  63
SER A 128
 None
 0.97A 4ikkA-2piaA:
undetectable
4ikkB-2piaA:
undetectable		 4ikkA-2piaA:
18.04
4ikkB-2piaA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 8 LEU A 319
LEU A 321
SER A 245
THR A 247
 None
 0.93A 4ikkA-2piaA:
undetectable
4ikkB-2piaA:
undetectable		 4ikkA-2piaA:
18.04
4ikkB-2piaA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 7 LEU A 319
LEU A 321
SER A 245
THR A 247
 None
 1.03A 4ikkA-2piaA:
undetectable
4ikkB-2piaA:
undetectable		 4ikkA-2piaA:
18.04
4ikkB-2piaA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		5 / 9 ALA A 154
THR A 153
ALA A  20
GLY A 119
GLY A 120
 None
 0.84A 4qwuK-2piaA:
undetectable
4qwuL-2piaA:
undetectable		 4qwuK-2piaA:
19.81
4qwuL-2piaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		5 / 9 ALA A 154
THR A 153
ALA A  20
GLY A 119
GLY A 120
 None
 0.92A 4qwuY-2piaA:
undetectable
4qwuZ-2piaA:
undetectable		 4qwuY-2piaA:
19.81
4qwuZ-2piaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 4 LEU A 258
ARG A 311
ILE A 257
ILE A 251
 None
 1.23A 5dzk2-2piaA:
undetectable
5dzkM-2piaA:
undetectable
5dzkN-2piaA:
undetectable		 5dzk2-2piaA:
0.62
5dzkM-2piaA:
20.67
5dzkN-2piaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2pia PHTHALATE
DIOXYGENASE
REDUCTASE
(Burkholderia
cepacia) 		4 / 4 ILE A 257
ILE A 251
ARG A 311
LEU A 258
 None
 1.33A 5dzkh-2piaA:
undetectable
5dzkn-2piaA:
undetectable
5dzkv-2piaA:
undetectable		 5dzkh-2piaA:
20.67
5dzkn-2piaA:
20.67
5dzkv-2piaA:
0.62