SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 10 LEU A 224
TYR A 177
GLY A 114
LEU A 119
TYR A 221
 None
None
None
None
YSA  A 384 (-4.7A)
 1.40A 1fkoA-2pidA:
undetectable		 1fkoA-2pidA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		6 / 11 GLY A  79
HIS A  88
HIS A  91
GLY A 244
ASP A 246
GLN A 247
 YSA  A 384 (-3.2A)
None
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
 0.65A 1jzsA-2pidA:
undetectable		 1jzsA-2pidA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		6 / 11 GLY A  79
HIS A  91
GLY A 244
ASP A 246
GLN A 247
ILE A 274
 YSA  A 384 (-3.2A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
YSA  A 384 (-4.4A)
 0.57A 1jzsA-2pidA:
undetectable		 1jzsA-2pidA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 11 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
 None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
 0.35A 1pg2A-2pidA:
8.4		 1pg2A-2pidA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 GLY A  90
HIS A  91
GLY A 244
ASP A 246
GLN A 247
 YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
 0.57A 1qu2A-2pidA:
4.3		 1qu2A-2pidA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
 None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
 0.85A 1qu2A-2pidA:
4.3		 1qu2A-2pidA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 HIS A  88
GLY A  90
HIS A  91
ASP A 246
GLN A 247
 None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
 0.95A 1qu3A-2pidA:
5.6		 1qu3A-2pidA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 ASP A  81
GLY A 113
GLY A 114
ASN A 173
 YSA  A 384 (-3.9A)
YSA  A 384 ( 4.6A)
None
YSA  A 384 ( 4.8A)
 0.69A 2c49B-2pidA:
undetectable		 2c49B-2pidA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 11 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
 None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
 0.45A 2x1lA-2pidA:
8.8		 2x1lA-2pidA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
 None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
 0.44A 2x1lB-2pidA:
8.4		 2x1lB-2pidA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 11 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
 None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
 0.47A 2x1lC-2pidA:
9.0		 2x1lC-2pidA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 9 PRO A 272
VAL A 271
GLY A 243
ILE A  76
GLY A  97
 None
None
YSA  A 384 (-3.1A)
None
None
 1.44A 3csjB-2pidA:
undetectable		 3csjB-2pidA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 GLN A 225
LEU A  98
VAL A 170
LEU A  87
 YSA  A 384 (-3.3A)
None
None
None
 0.86A 3g8iA-2pidA:
undetectable		 3g8iA-2pidA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 MET A 195
MET A 252
PHE A 220
 None
 0.81A 3gn8A-2pidA:
undetectable		 3gn8A-2pidA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 ASN A 259
GLY A 268
THR A 270
ASP A 265
THR A  57
 None
 1.23A 3iv6A-2pidA:
2.1		 3iv6A-2pidA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 ASN A 173
TRP A 176
ASP A  81
 YSA  A 384 ( 4.8A)
None
YSA  A 384 (-3.9A)
 0.78A 4a7tA-2pidA:
undetectable
4a7tF-2pidA:
undetectable		 4a7tA-2pidA:
17.61
4a7tF-2pidA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 ILE A 251
VAL A 271
LEU A  47
ILE A 269
 None
 0.90A 4asdA-2pidA:
undetectable		 4asdA-2pidA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 11 ILE A 269
ALA A  94
LEU A  47
PHE A  48
LEU A  38
 None
YSA  A 384 ( 3.7A)
None
None
None
 1.38A 4i1nA-2pidA:
undetectable		 4i1nA-2pidA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 4 ILE A 329
ILE A 332
ARG A 348
LEU A 326
 None
 1.39A 5dzkh-2pidA:
undetectable
5dzkn-2pidA:
undetectable
5dzkv-2pidA:
undetectable		 5dzkh-2pidA:
18.77
5dzkn-2pidA:
18.77
5dzkv-2pidA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 ALA A  94
GLY A 244
GLY A  79
HIS A  91
LEU A 292
 YSA  A 384 ( 3.7A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.2A)
YSA  A 384 (-4.1A)
None
 0.96A 5gwxA-2pidA:
2.5		 5gwxA-2pidA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
 None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
 0.94A 5hg0B-2pidA:
7.2		 5hg0B-2pidA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 ARG A 103
PHE A 321
PHE A 159
 None
 1.02A 6nknC-2pidA:
undetectable
6nknJ-2pidA:
undetectable		 6nknC-2pidA:
22.22
6nknJ-2pidA:
11.25