SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 2pie E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		4 / 6 LEU A  66
ILE A  59
ARG A  42
VAL A  85
 None
 0.99A 1db1A-2pieA:
undetectable		 1db1A-2pieA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pie E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		3 / 3 LEU A  50
TRP A  29
TYR A  48
 None
 0.99A 3aicA-2pieA:
undetectable		 3aicA-2pieA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pie E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		3 / 3 LEU A  50
TRP A  29
TYR A  48
 None
 0.97A 3aicB-2pieA:
undetectable		 3aicB-2pieA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pie E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		3 / 3 LEU A  50
TRP A  29
TYR A  48
 None
 0.98A 3aicE-2pieA:
undetectable		 3aicE-2pieA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pie E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		3 / 3 LEU A  50
TRP A  29
TYR A  48
 None
 1.00A 3aicG-2pieA:
undetectable		 3aicG-2pieA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2pie E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		3 / 3 LEU A  50
TRP A  29
TYR A  48
 None
 0.96A 3aicH-2pieA:
undetectable		 3aicH-2pieA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2pie E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		4 / 5 ILE A 100
LEU A  30
HIS A  63
VAL A  85
 None
 1.18A 5jmnB-2pieA:
undetectable		 5jmnB-2pieA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2pie E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		5 / 11 GLY A  45
ASN A  62
HIS A  63
CYH A  64
ILE A  59
 None
 1.40A 6agoA-2pieA:
undetectable		 6agoA-2pieA:
16.93