SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 GLY A 203
GLU A 201
ASN A 208
 None
 0.66A 1zq9A-2pifA:
undetectable		 1zq9A-2pifA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 MET A 171
ILE A 221
PRO A 196
SER A 186
 None
 1.41A 2qd3B-2pifA:
undetectable		 2qd3B-2pifA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 8 LEU A  42
ILE A  89
LEU A  85
THR A  77
LEU A 121
 None
 1.48A 2xfhA-2pifA:
undetectable		 2xfhA-2pifA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA A 231
GLY A 233
GLY A 123
LEU A 205
THR A 153
 None
 1.04A 2y7hC-2pifA:
undetectable		 2y7hC-2pifA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 PRO A  29
ASN A  41
VAL A 234
TYR A 255
PHE A 215
 None
 1.46A 3megA-2pifA:
2.1		 3megA-2pifA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 ASN A 208
ILE A 207
PHE A 229
MET A 171
 None
 1.17A 3tvxB-2pifA:
undetectable		 3tvxB-2pifA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 4 ALA A  11
ALA A  14
ALA A  15
ALA A  18
 None
 0.13A 4oadA-2pifA:
undetectable		 4oadA-2pifA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 4 ALA A  11
ALA A  14
ALA A  15
ALA A  18
 None
 0.12A 4oaeA-2pifA:
undetectable		 4oaeA-2pifA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 SER A  83
GLY A  82
ARG A  19
PHE A 257
 None
 1.22A 4r82A-2pifA:
undetectable
4r82B-2pifA:
undetectable		 4r82A-2pifA:
24.46
4r82B-2pifA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 THR A  77
GLY A  82
ARG A  23
ALA A  80
 None
 0.88A 4txnA-2pifA:
undetectable		 4txnA-2pifA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 THR A  77
GLY A  82
ARG A  23
ALA A  80
 None
 0.91A 4txnB-2pifA:
undetectable		 4txnB-2pifA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 THR A  77
GLY A  82
ARG A  23
ALA A  80
 None
 0.89A 4txnC-2pifA:
undetectable		 4txnC-2pifA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 2pif UPF0317 PROTEIN
PSPTO_5379
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 THR A  77
GLY A  82
ARG A  23
ALA A  80
 None
 0.93A 4txnD-2pifA:
undetectable		 4txnD-2pifA:
20.57