SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pim'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis)
4 / 7 LEU A  87
ALA A 132
VAL A 116
TYR A  42
None
0.76A 1epbA-2pimA:
2.9
1epbA-2pimA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis)
4 / 8 LEU A  87
ALA A 132
VAL A 116
TYR A  42
None
0.88A 1epbB-2pimA:
undetectable
1epbB-2pimA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis)
4 / 8 ALA A 104
LEU A 106
ALA A  74
THR A  75
None
0.86A 1ie4B-2pimA:
undetectable
1ie4D-2pimA:
undetectable
1ie4B-2pimA:
21.94
1ie4D-2pimA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis)
5 / 11 PHE A  91
ALA A  62
VAL A  55
MET A  63
LEU A 100
None
1.42A 1qabE-2pimA:
0.0
1qabE-2pimA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis)
3 / 3 ARG A 105
THR A 131
VAL A 117
None
0.98A 2q64A-2pimA:
undetectable
2q64A-2pimA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis)
3 / 3 ARG A 105
THR A 131
VAL A 117
None
0.92A 2qakA-2pimA:
undetectable
2qakA-2pimA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis)
4 / 7 PRO A  18
ALA A  21
ALA A  62
ASP A  65
None
0.85A 3ur0B-2pimA:
undetectable
3ur0B-2pimA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)
2pim PHENYLACETIC ACID
DEGRADATION-RELATED
PROTEIN

(Cupriavidus
pinatubonensis)
4 / 7 PRO A  18
GLY A  22
ALA A  21
ALA A  62
None
0.83A 3ur0B-2pimA:
undetectable
3ur0B-2pimA:
15.52