SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2pjp SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Escherichia
coli) 		4 / 8 ASP A 607
PHE A 590
LEU A 560
ASP A 561
 None
None
None
CA  A 102 (-3.1A)
 0.83A 3m0wE-2pjpA:
undetectable
3m0wF-2pjpA:
undetectable
3m0wG-2pjpA:
undetectable
3m0wH-2pjpA:
undetectable		 3m0wE-2pjpA:
22.48
3m0wF-2pjpA:
22.48
3m0wG-2pjpA:
22.48
3m0wH-2pjpA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pjp SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Escherichia
coli) 		4 / 6 VAL A 578
ARG A 546
ILE A 536
PHE A 502
 None
 0.97A 5jw1B-2pjpA:
undetectable		 5jw1B-2pjpA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2pjp SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Escherichia
coli) 		5 / 12 THR A 537
ALA A 538
ILE A 535
GLY A 534
LEU A 527
 None
 0.87A 5nfjA-2pjpA:
undetectable		 5nfjA-2pjpA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2pjp SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Escherichia
coli) 		3 / 3 THR A 537
GLU A 499
ASN A 547
 None
 0.83A 6nj9K-2pjpA:
undetectable		 6nj9K-2pjpA:
19.23