SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pjz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		4 / 7 ILE A 167
TYR A 191
ASP A 186
GLU A 184
 None
 1.14A 2qebA-2pjzA:
undetectable		 2qebA-2pjzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A  49
LEU A   4
VAL A   7
ILE A  35
LEU A 204
 None
 1.24A 2qk8A-2pjzA:
undetectable		 2qk8A-2pjzA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		3 / 3 PHE A 198
SER A 216
LEU A 214
 None
 0.83A 2w1bA-2pjzA:
undetectable		 2w1bA-2pjzA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A  49
LEU A   4
VAL A   7
ILE A  35
LEU A 204
 None
 1.15A 3datA-2pjzA:
undetectable		 3datA-2pjzA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A  49
LEU A   4
VAL A   7
ILE A  35
LEU A 204
 None
 1.05A 3fl9B-2pjzA:
undetectable		 3fl9B-2pjzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A  49
LEU A   4
VAL A   7
ILE A  35
LEU A 204
 None
 1.07A 3fl9C-2pjzA:
undetectable		 3fl9C-2pjzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 10 ALA A  49
LEU A   4
VAL A   7
ILE A  35
LEU A 204
 None
 1.15A 3fl9E-2pjzA:
undetectable		 3fl9E-2pjzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A  49
LEU A   4
VAL A   7
ILE A  35
LEU A 204
 None
 1.10A 3fl9G-2pjzA:
undetectable		 3fl9G-2pjzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		6 / 12 ALA A 142
GLU A  82
LEU A  53
THR A  78
ILE A   9
LEU A  47
 None
 1.38A 3gcsA-2pjzA:
undetectable		 3gcsA-2pjzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		4 / 8 THR A  44
LEU A  47
ALA A  49
SER A  51
 SO4  A 502 (-3.7A)
None
None
None
 1.03A 3kp6A-2pjzA:
undetectable		 3kp6A-2pjzA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 11 PRO A 155
ASP A 153
ASN A  79
ALA A  49
THR A  44
 None
None
None
None
SO4  A 502 (-3.7A)
 1.28A 3n23A-2pjzA:
undetectable		 3n23A-2pjzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 11 PRO A 155
ASP A 153
ASN A  79
ALA A  49
THR A  44
 None
None
None
None
SO4  A 502 (-3.7A)
 1.28A 3n23C-2pjzA:
undetectable		 3n23C-2pjzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  37
PHE A 248
ILE A 218
TYR A 258
ILE A 257
 None
 1.04A 3pwwA-2pjzA:
undetectable		 3pwwA-2pjzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		4 / 6 VAL A   7
ASN A  25
TYR A  56
GLU A  66
 None
 1.18A 3q5sA-2pjzA:
undetectable		 3q5sA-2pjzA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		3 / 3 GLY A  40
GLY A  42
THR A  44
 SO4  A 502 (-3.5A)
SO4  A 502 (-3.5A)
SO4  A 502 (-3.7A)
 0.44A 3si7B-2pjzA:
11.6		 3si7B-2pjzA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 10 ILE A 167
VAL A 135
PHE A 156
ILE A  34
ILE A 171
 None
 1.11A 3um5A-2pjzA:
undetectable		 3um5A-2pjzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 124
LYS A 125
LYS A 128
 None
 1.39A 4k50A-2pjzA:
undetectable		 4k50A-2pjzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 254
VAL A 237
ILE A 260
ILE A 232
GLY A 201
 None
 0.98A 4y8wC-2pjzA:
undetectable		 4y8wC-2pjzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 2pjz HYPOTHETICAL PROTEIN
ST1066
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 185
GLY A 252
ARG A 256
SER A 217
LEU A  36
 None
 1.25A 5czyA-2pjzA:
undetectable		 5czyA-2pjzA:
22.04