SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		5 / 12 ILE A   3
LEU A 181
ARG A 125
VAL A 189
ILE A 121
 None
 1.00A 1epbB-2pk0A:
undetectable		 1epbB-2pk0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		5 / 12 GLU A  79
ILE A  78
PRO A 174
ASP A 175
ILE A 101
 None
 1.46A 1kijA-2pk0A:
undetectable		 1kijA-2pk0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		4 / 6 GLN A  17
ASN A  15
ASN A 190
LEU A  34
 None
 1.17A 2nyrA-2pk0A:
undetectable		 2nyrA-2pk0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		5 / 9 ASP A 118
VAL A 116
ILE A 166
GLY A  98
THR A 163
 None
 1.19A 3el4B-2pk0A:
undetectable		 3el4B-2pk0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		4 / 8 SER A 134
ASN A 140
GLN A 164
ASP A 175
 None
 1.33A 3n62A-2pk0A:
undetectable		 3n62A-2pk0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		4 / 8 SER A 134
ASN A 140
GLN A 164
ASP A 175
 None
 1.32A 3n66B-2pk0A:
undetectable		 3n66B-2pk0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		4 / 7 SER A 134
ASN A 140
GLN A 164
ASP A 175
 None
 1.31A 4kcnB-2pk0A:
undetectable		 4kcnB-2pk0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		4 / 4 VAL A 143
THR A 149
GLU A 150
GLU A 151
 None
 1.24A 4l78A-2pk0A:
undetectable		 4l78A-2pk0A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		5 / 9 ILE A   3
THR A 234
SER A 119
ILE A 101
VAL A 189
 None
 1.09A 4r21B-2pk0A:
undetectable		 4r21B-2pk0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		4 / 6 LEU A 194
LEU A 198
SER A 199
VAL A 124
 None
 1.03A 5a6iA-2pk0A:
undetectable		 5a6iA-2pk0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		4 / 6 ARG A  13
ASP A  36
GLY A  37
ASP A  18
 None
MG  A 502 ( 2.7A)
MG  A 501 (-4.0A)
MG  A 502 ( 4.7A)
 1.31A 5hp1A-2pk0A:
undetectable		 5hp1A-2pk0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		4 / 7 GLY A  37
SER A 119
ASP A  18
ASN A  15
 MG  A 501 (-4.0A)
None
MG  A 502 ( 4.7A)
None
 1.09A 5n5dB-2pk0A:
undetectable		 5n5dB-2pk0A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		4 / 8 SER A 134
ASN A 140
GLN A 164
ASP A 175
 None
 1.35A 5vunB-2pk0A:
undetectable		 5vunB-2pk0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		5 / 12 ILE A 203
LEU A   6
GLN A 218
ASN A 217
LEU A 198
 None
 1.28A 5xxiA-2pk0A:
undetectable		 5xxiA-2pk0A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1
(Streptococcus
agalactiae) 		3 / 3 ASN A 160
VAL A 116
HIS A 136
 None
 0.84A 6a5yD-2pk0A:
undetectable		 6a5yD-2pk0A:
15.52