SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2pk2 CYCLIN-T1, PROTEIN
TAT
(Homo
sapiens;
Equine
infectious
anemia
virus) 		3 / 3 ASP A  32
LEU A  35
GLN A 190
 ASP  A  32 ( 0.6A)
LEU  A  35 ( 0.6A)
GLN  A 190 ( 0.6A)
 0.59A 3g4lA-2pk2A:
undetectable		 3g4lA-2pk2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2pk2 CYCLIN-T1, PROTEIN
TAT
(Homo
sapiens;
Equine
infectious
anemia
virus) 		4 / 6 LEU A  90
PHE A  89
LEU A 141
PHE A 146
 LEU  A  90 ( 0.6A)
PHE  A  89 ( 1.3A)
LEU  A 141 ( 0.6A)
PHE  A 146 ( 1.3A)
 1.04A 3wg7P-2pk2A:
undetectable
3wg7W-2pk2A:
undetectable		 3wg7P-2pk2A:
20.56
3wg7W-2pk2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pk2 CYCLIN-T1, PROTEIN
TAT
(Homo
sapiens;
Equine
infectious
anemia
virus) 		3 / 3 TYR A  13
THR A 192
GLU A 147
 TYR  A  13 ( 1.3A)
THR  A 192 ( 0.8A)
GLU  A 147 ( 0.6A)
 0.83A 4df3A-2pk2A:
undetectable		 4df3A-2pk2A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2pk2 CYCLIN-T1, PROTEIN
TAT
(Homo
sapiens;
Equine
infectious
anemia
virus) 		3 / 3 GLN A  39
THR A 185
THR A 186
 GLN  A  39 ( 0.6A)
THR  A 185 ( 0.8A)
THR  A 186 ( 0.8A)
 0.70A 4fu9A-2pk2A:
undetectable		 4fu9A-2pk2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2pk2 CYCLIN-T1, PROTEIN
TAT
(Homo
sapiens;
Equine
infectious
anemia
virus) 		3 / 3 GLN A  39
THR A 185
THR A 186
 GLN  A  39 ( 0.6A)
THR  A 185 ( 0.8A)
THR  A 186 ( 0.8A)
 0.68A 4fufA-2pk2A:
undetectable		 4fufA-2pk2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2pk2 CYCLIN-T1, PROTEIN
TAT
(Homo
sapiens;
Equine
infectious
anemia
virus) 		4 / 7 ASP A  47
GLN A  50
ASN A  43
ILE A  63
 ASP  A  47 ( 0.6A)
GLN  A  50 ( 0.6A)
ASN  A  43 ( 0.6A)
ILE  A  63 ( 0.7A)
 1.23A 4ii8A-2pk2A:
undetectable		 4ii8A-2pk2A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2pk2 CYCLIN-T1, PROTEIN
TAT
(Equine
infectious
anemia
virus;
Homo
sapiens) 		3 / 3 ILE A 105
MET A  48
ARG A  51
 ILE  A 105 ( 0.7A)
MET  A  48 ( 0.0A)
ARG  A  51 ( 0.6A)
 0.90A 4lnwA-2pk2A:
undetectable		 4lnwA-2pk2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2pk2 CYCLIN-T1, PROTEIN
TAT
(Equine
infectious
anemia
virus;
Homo
sapiens) 		3 / 3 ILE A 105
MET A  48
ARG A  51
 ILE  A 105 ( 0.7A)
MET  A  48 ( 0.0A)
ARG  A  51 ( 0.6A)
 0.89A 4lnxA-2pk2A:
1.8		 4lnxA-2pk2A:
19.95