SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  55
TRP A  62
ARG A  71
TRP A  72
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 0.98A 1b2iA-2pk4A:
12.6		 1b2iA-2pk4A:
48.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  57
TRP A  62
PHE A  64
TRP A  72
 ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 4.1A)
ACA  A 100 ( 3.1A)
 1.20A 1b2iA-2pk4A:
12.6		 1b2iA-2pk4A:
48.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 TRP A  62
PHE A  64
ARG A  71
TRP A  72
 ACA  A 100 ( 3.6A)
ACA  A 100 ( 4.1A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 1.08A 1b2iA-2pk4A:
12.6		 1b2iA-2pk4A:
48.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 8 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.53A 1ceaA-2pk4A:
undetectable
1ceaB-2pk4A:
15.9		 1ceaA-2pk4A:
51.22
1ceaB-2pk4A:
51.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.50A 1ceaB-2pk4A:
15.9		 1ceaB-2pk4A:
51.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.57A 1cebA-2pk4A:
15.9		 1cebA-2pk4A:
51.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.53A 1cebB-2pk4A:
15.8		 1cebB-2pk4A:
51.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		3 / 3 GLN A  23
HIS A  31
PRO A  68
 None
 0.86A 1d8cA-2pk4A:
undetectable		 1d8cA-2pk4A:
8.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 8 ASP A  55
ASP A  57
TRP A  62
TRP A  72
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 0.79A 1pk2A-2pk4A:
9.5		 1pk2A-2pk4A:
42.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		4 / 4 PRO A  54
TYR A  41
GLY A  45
THR A  47
 None
 1.44A 3ib0A-2pk4A:
undetectable		 3ib0A-2pk4A:
12.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 2pk4 HUMAN PLASMINOGEN
KRINGLE 4
(Homo
sapiens) 		6 / 7 ASP A  55
ASP A  57
TRP A  62
PHE A  64
ARG A  71
TRP A  72
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 4.1A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 0.35A 3kivA-2pk4A:
17.5		 3kivA-2pk4A:
85.00