SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2pk9 PHO85 CYCLIN PHO80
(Saccharomyces
cerevisiae) 		5 / 9 VAL B 147
VAL B 150
TYR B 144
GLY B 148
LEU B  90
 None
 1.42A 1lwfA-2pk9B:
undetectable		 1lwfA-2pk9B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2pk9 PHO85 CYCLIN PHO80
(Saccharomyces
cerevisiae) 		4 / 4 LEU B 123
SER B  40
LEU B  90
LEU B  84
 None
 0.85A 1yajA-2pk9B:
undetectable		 1yajA-2pk9B:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2pk9 PHO85 CYCLIN PHO80
(Saccharomyces
cerevisiae) 		5 / 11 THR B 127
LEU B 155
VAL B 150
SER B 139
LEU B  84
 None
 1.34A 3tbgA-2pk9B:
undetectable		 3tbgA-2pk9B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2pk9 PHO85 CYCLIN PHO80
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 217
TYR B 100
TYR B 101
LEU B 134
 None
 1.15A 4b3qA-2pk9B:
undetectable		 4b3qA-2pk9B:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2pk9 PHO85 CYCLIN PHO80
(Saccharomyces
cerevisiae) 		3 / 3 LYS B  86
THR B  85
ILE B  39
 None
 0.90A 4e0fB-2pk9B:
undetectable		 4e0fB-2pk9B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pk9 PHO85 CYCLIN PHO80
(Saccharomyces
cerevisiae) 		4 / 5 MET B  96
LEU B  35
ARG B 222
PRO B 172
 None
 1.22A 4kmmB-2pk9B:
undetectable		 4kmmB-2pk9B:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2pk9 PHO85 CYCLIN PHO80
(Saccharomyces
cerevisiae) 		5 / 10 ILE B  77
ALA B 119
LEU B 123
ILE B 102
ILE B 224
 None
 0.98A 5mvmD-2pk9B:
undetectable
5mvmE-2pk9B:
undetectable		 5mvmD-2pk9B:
13.94
5mvmE-2pk9B:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2pk9 PHO85 CYCLIN PHO80
(Saccharomyces
cerevisiae) 		4 / 7 ALA B 126
ILE B  47
LEU B 114
ILE B  75
 None
None
None
MES  B 294 (-4.0A)
 0.89A 6b5vA-2pk9B:
undetectable
6b5vB-2pk9B:
undetectable		 6b5vA-2pk9B:
14.34
6b5vB-2pk9B:
14.34