SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 8 HIS A  57
ASP B 189
SER B 195
GLY B 216
 None
BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
BEN  B   1 (-3.5A)
 0.57A 1aq7A-2pkaA:
7.5		 1aq7A-2pkaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2pka KALLIKREIN A
(Sus
scrofa) 		5 / 12 HIS A  57
ASP B 189
SER B 195
TRP B 215
GLY B 216
 None
BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
None
BEN  B   1 (-3.5A)
 0.51A 1etrH-2pkaA:
6.9		 1etrH-2pkaA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 4 SER B 226
LEU B 160
TYR B 228
GLY B 221
 BEN  B   1 (-2.7A)
None
None
None
 1.11A 1liiA-2pkaB:
undetectable		 1liiA-2pkaB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 4 LEU B 199
GLY B 184
ASP B 189
TYR B 228
 None
None
BEN  B   1 (-3.0A)
None
 1.24A 1oxrA-2pkaB:
undetectable		 1oxrA-2pkaB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2pka KALLIKREIN A
(Sus
scrofa) 		6 / 12 TYR B  99
ASP B 189
SER B 195
TRP B 215
GLY B 216
TYR B 228
 None
BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
None
BEN  B   1 (-3.5A)
None
 0.70A 2p16A-2pkaB:
16.0		 2p16A-2pkaB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2pka KALLIKREIN A
(Sus
scrofa) 		5 / 12 ASP B 189
SER B 195
TRP B 215
GLY B 216
TYR B 228
 BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
None
BEN  B   1 (-3.5A)
None
 0.50A 2w26A-2pkaB:
14.8		 2w26A-2pkaB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2pka KALLIKREIN A
(Sus
scrofa) 		5 / 12 TYR B  99
ASP B 189
TRP B 215
GLY B 216
TYR B 228
 None
BEN  B   1 (-3.0A)
None
BEN  B   1 (-3.5A)
None
 0.51A 2w26A-2pkaB:
14.8		 2w26A-2pkaB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 4 ARG A  70
GLY A  69
GLU A  77
SER B 110
 None
 1.35A 2xctS-2pkaA:
undetectable
2xctU-2pkaA:
undetectable		 2xctS-2pkaA:
8.38
2xctU-2pkaA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 6 TRP B 141
SER B 139
ALA B 138
ASP B 194
 None
 1.13A 3aruA-2pkaB:
undetectable		 3aruA-2pkaB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2pka KALLIKREIN A
KALLIKREIN A
(Sus
scrofa;
Sus
scrofa) 		5 / 11 HIS A  57
ASP B 189
SER B 195
TRP B 215
GLY B 216
 None
BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
None
BEN  B   1 (-3.5A)
 0.38A 3gy3A-2pkaA:
10.7		 3gy3A-2pkaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 4 LEU B 162
GLY B 133
LEU B 132
GLU B 130
 None
 1.06A 3tgvB-2pkaB:
undetectable		 3tgvB-2pkaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 7 SER A  38
ARG A  70
PHE A  82
GLU A  64
 None
 1.33A 4xzkA-2pkaA:
undetectable		 4xzkA-2pkaA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 5 ARG A  70
GLY A  69
GLU A  77
SER B 110
 None
 1.24A 4z3oA-2pkaA:
undetectable
4z3oB-2pkaA:
undetectable		 4z3oA-2pkaA:
6.98
4z3oB-2pkaA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 8 ASN B 245
PRO B 246
PHE A  89
TRP A  51
 None
 1.44A 5amkA-2pkaB:
undetectable		 5amkA-2pkaB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 6 SER B 110
ARG A  70
GLY A  69
GLU A  77
 None
 1.06A 5btaA-2pkaB:
undetectable
5btaB-2pkaB:
undetectable
5btaC-2pkaB:
undetectable		 5btaA-2pkaB:
14.80
5btaB-2pkaB:
20.80
5btaC-2pkaB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 6 SER B 110
ARG A  70
GLY A  69
GLU A  77
 None
 1.04A 5btcA-2pkaB:
undetectable
5btcC-2pkaB:
undetectable
5btcD-2pkaB:
undetectable		 5btcA-2pkaB:
14.80
5btcC-2pkaB:
14.80
5btcD-2pkaB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 6 SER B 110
ARG A  70
GLY A  69
GLU A  77
 None
 1.06A 5btcA-2pkaB:
undetectable
5btcB-2pkaB:
undetectable
5btcC-2pkaB:
undetectable		 5btcA-2pkaB:
14.80
5btcB-2pkaB:
20.80
5btcC-2pkaB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 7 SER B 110
ARG A  70
GLY A  69
GLU A  77
 None
 1.04A 5btfA-2pkaB:
undetectable
5btfC-2pkaB:
undetectable
5btfD-2pkaB:
undetectable		 5btfA-2pkaB:
14.80
5btfC-2pkaB:
14.80
5btfD-2pkaB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 5 SER B 110
ARG A  70
GLY A  69
GLU A  77
 None
 1.17A 5btiA-2pkaB:
undetectable
5btiB-2pkaB:
undetectable		 5btiA-2pkaB:
14.80
5btiB-2pkaB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 5 SER B 110
ARG A  70
GLY A  69
GLU A  77
 None
 1.16A 5btiC-2pkaB:
undetectable
5btiD-2pkaB:
undetectable		 5btiC-2pkaB:
14.80
5btiD-2pkaB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 5 SER B 110
ARG A  70
GLY A  69
GLU A  77
 None
 1.15A 5cdqA-2pkaB:
undetectable
5cdqB-2pkaB:
undetectable
5cdqC-2pkaB:
undetectable		 5cdqA-2pkaB:
14.74
5cdqB-2pkaB:
22.96
5cdqC-2pkaB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2pka KALLIKREIN A
(Sus
scrofa) 		4 / 5 SER B 110
ARG A  70
GLY A  69
GLU A  77
 None
 1.14A 5cdqR-2pkaB:
undetectable
5cdqS-2pkaB:
undetectable
5cdqT-2pkaB:
undetectable		 5cdqR-2pkaB:
14.74
5cdqS-2pkaB:
22.96
5cdqT-2pkaB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 2pka KALLIKREIN A
KALLIKREIN A
(Sus
scrofa;
Sus
scrofa) 		6 / 12 GLY B 142
GLY A  44
GLY B 196
GLY B 193
THR A  54
VAL A  52
 None
 1.34A 5eiwC-2pkaB:
undetectable		 5eiwC-2pkaB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pka KALLIKREIN A
KALLIKREIN A
(Sus
scrofa;
Sus
scrofa) 		3 / 3 SER B 214
SER B 195
PHE A  94
 None
BEN  B   1 ( 4.0A)
None
 0.83A 5mugA-2pkaB:
undetectable		 5mugA-2pkaB:
19.74