SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TBF_A_VIAA501_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	2pkd	SLAM FAMILY MEMBER 5 (Homo sapiens)	5 / 9	LEU A 79 LEU A 106 VAL A 40 ALA A 41 PHE A 19	None	1.05A	1tbfA-2pkdA: undetectable	1tbfA-2pkdA: 15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	2pkd	SLAM FAMILY MEMBER 5 (Homo sapiens)	5 / 12	ASP A 96 TYR A 98 THR A 99 ILE A 91 ASN A 92	None	1.27A	3rzeA-2pkdA: undetectable	3rzeA-2pkdA: 14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YBN_A_ACTA303_0 (FLAVIN-NUCLEOTIDE-BI NDING PROTEIN)	2pkd	SLAM FAMILY MEMBER 5 (Homo sapiens)	3 / 3	VAL A 43 TYR A 72 ALA A 67	None	0.54A	4ybnA-2pkdA: undetectable	4ybnA-2pkdA: 20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AOX_C_ACTC1001_0 (ALU JO CONSENSUS RNA SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN)	2pkd	SLAM FAMILY MEMBER 5 (Homo sapiens)	3 / 3	TYR A 42 THR A 44 THR A 55	None	0.67A	5aoxB-2pkdA: undetectable	5aoxB-2pkdA: 27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AOX_F_ACTF1001_0 (ALU JO CONSENSUS RNA SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN)	2pkd	SLAM FAMILY MEMBER 5 (Homo sapiens)	3 / 3	TYR A 42 THR A 44 THR A 55	None	0.66A	5aoxE-2pkdA: undetectable	5aoxE-2pkdA: 27.12

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1TBF_A_VIAA501_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","2pkd","SLAM FAMILY MEMBER 5","Homo sapiens",5,"LEU A  79;LEU A 106;VAL A  40;ALA A  41;PHE A  19","None","1.05A","1tbfA-2pkdA:undetectable","1tbfA-2pkdA:15.00"],["3RZE_A_D7VA1201_1","HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA","2pkd","SLAM FAMILY MEMBER 5","Homo sapiens",5,"ASP A  96;TYR A  98;THR A  99;ILE A  91;ASN A  92","None","1.27A","3rzeA-2pkdA:undetectable","3rzeA-2pkdA:14.48"],["4YBN_A_ACTA303_0","FLAVIN-NUCLEOTIDE-BINDING PROTEIN","2pkd","SLAM FAMILY MEMBER 5","Homo sapiens",3,"VAL A  43;TYR A  72;ALA A  67","None","0.54A","4ybnA-2pkdA:undetectable","4ybnA-2pkdA:20.09"],["5AOX_C_ACTC1001_0","ALU JO CONSENSUS RNA;SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN","2pkd","SLAM FAMILY MEMBER 5","Homo sapiens",3,"TYR A  42;THR A  44;THR A  55","None","0.67A","5aoxB-2pkdA:undetectable","5aoxB-2pkdA:27.12"],["5AOX_F_ACTF1001_0","ALU JO CONSENSUS RNA;SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN","2pkd","SLAM FAMILY MEMBER 5","Homo sapiens",3,"TYR A  42;THR A  44;THR A  55","None","0.66A","5aoxE-2pkdA:undetectable","5aoxE-2pkdA:27.12"]]