SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 11 MET A 183
PHE A 181
ALA A 168
LEU A 171
ALA A 178
 None
 1.41A 1jb0B-2pkeA:
1.5		 1jb0B-2pkeA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 12 ILE A 184
THR A 205
GLY A  19
LEU A 131
LEU A  23
 None
 0.89A 1rjdA-2pkeA:
2.5		 1rjdA-2pkeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 12 ILE A 184
THR A 205
GLY A  19
LEU A 131
LEU A  23
 None
 0.89A 1rjdB-2pkeA:
2.7		 1rjdB-2pkeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 12 ILE A 184
THR A 205
GLY A  19
LEU A 131
LEU A  23
 None
 0.88A 1rjdC-2pkeA:
2.8		 1rjdC-2pkeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		3 / 3 VAL A 182
VAL A 192
TRP A 201
 None
 0.96A 1w5uA-2pkeA:
undetectable
1w5uB-2pkeA:
undetectable		 1w5uA-2pkeA:
5.32
1w5uB-2pkeA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		3 / 3 SER A 147
THR A 133
GLN A 140
 None
None
CL  A 301 (-4.1A)
 0.83A 2fk8A-2pkeA:
undetectable		 2fk8A-2pkeA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		3 / 3 VAL A 192
TRP A 201
VAL A 182
 None
 0.95A 2izqC-2pkeA:
undetectable
2izqD-2pkeA:
undetectable		 2izqC-2pkeA:
5.32
2izqD-2pkeA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 12 ILE A 203
VAL A 116
LEU A  23
PHE A 153
ALA A 124
 None
 1.22A 2jj8C-2pkeA:
undetectable		 2jj8C-2pkeA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 11 LEU A  56
ILE A  98
ALA A  82
THR A  86
LEU A  45
 None
 1.32A 2v0mD-2pkeA:
undetectable		 2v0mD-2pkeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 12 ALA A 246
GLY A 199
LEU A 196
VAL A  15
ILE A  12
 None
 0.92A 3em6B-2pkeA:
undetectable		 3em6B-2pkeA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 11 MET A 183
PHE A 181
ALA A 168
LEU A 171
ALA A 178
 None
 1.41A 3pcqB-2pkeA:
1.5		 3pcqB-2pkeA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		4 / 6 ALA A 128
GLY A  16
ILE A   4
VAL A 170
 None
 0.75A 4r21A-2pkeA:
undetectable		 4r21A-2pkeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		3 / 3 LYS A 143
HIS A 108
HIS A 139
 None
 1.43A 5oexB-2pkeA:
undetectable		 5oexB-2pkeA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		3 / 3 LYS A 143
HIS A 108
HIS A 139
 None
 1.43A 5oexC-2pkeA:
undetectable		 5oexC-2pkeA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		3 / 3 LYS A 143
HIS A 108
HIS A 139
 None
 1.41A 5oexD-2pkeA:
undetectable		 5oexD-2pkeA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 12 MET A 183
PHE A 181
ALA A 168
LEU A 171
ALA A 178
 None
 1.28A 5oy02-2pkeA:
undetectable		 5oy02-2pkeA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		5 / 10 MET A 183
PHE A 181
ALA A 168
LEU A 171
ALA A 178
 None
 1.34A 5oy0b-2pkeA:
1.0		 5oy0b-2pkeA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		4 / 8 GLU A 100
GLY A 102
GLN A 107
LEU A 106
 None
 0.95A 5sxqA-2pkeA:
undetectable		 5sxqA-2pkeA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		4 / 8 GLU A 100
GLY A 102
GLN A 107
LEU A 106
 None
 0.94A 5sxqB-2pkeA:
undetectable		 5sxqB-2pkeA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		4 / 8 GLU A 100
GLY A 102
GLN A 107
THR A 105
 None
 1.02A 5sxqB-2pkeA:
undetectable		 5sxqB-2pkeA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		4 / 8 GLU A 100
GLY A 102
GLN A 107
LEU A 106
 None
 0.97A 5sxtA-2pkeA:
undetectable		 5sxtA-2pkeA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		4 / 8 GLU A 100
GLY A 102
GLN A 107
LEU A 106
 None
 0.96A 5sxtB-2pkeA:
undetectable		 5sxtB-2pkeA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE
(Xanthomonas
campestris) 		3 / 3 GLN A 245
TRP A 201
VAL A 182
 None
 0.71A 6auuA-2pkeA:
2.4		 6auuA-2pkeA:
22.38