SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)
2pkg SMALL T ANTIGEN
(Macaca
mulatta
polyomavirus
1)
4 / 8 ARG C 145
PHE C 148
GLY C 149
TRP C 135
None
0.91A 1fapB-2pkgC:
undetectable
1fapB-2pkgC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 7 LYS A 163
LEU A 166
PHE A 170
PHE A 128
None
0.88A 1v55P-2pkgA:
undetectable
1v55W-2pkgA:
undetectable
1v55P-2pkgA:
18.53
1v55W-2pkgA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 7 LYS A 163
LEU A 166
PHE A 170
PHE A 128
None
0.94A 2dysC-2pkgA:
undetectable
2dysJ-2pkgA:
undetectable
2dysC-2pkgA:
18.53
2dysJ-2pkgA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 7 LYS A 163
LEU A 166
PHE A 170
PHE A 128
None
0.94A 2eijP-2pkgA:
undetectable
2eijW-2pkgA:
undetectable
2eijP-2pkgA:
18.53
2eijW-2pkgA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 7 LYS A 163
LEU A 166
PHE A 170
PHE A 128
None
1.00A 2einC-2pkgA:
undetectable
2einJ-2pkgA:
undetectable
2einC-2pkgA:
18.53
2einJ-2pkgA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 12 ILE A 326
ILE A 322
CYH A 310
VAL A 306
LEU A 365
None
1.05A 2ft9A-2pkgA:
undetectable
2ft9A-2pkgA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 6 PHE A 209
LEU A 270
ALA A 251
ALA A 224
None
0.92A 2vcvB-2pkgA:
3.0
2vcvB-2pkgA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 6 PHE A 209
LEU A 270
ALA A 251
ALA A 224
None
0.91A 2vcvK-2pkgA:
3.0
2vcvK-2pkgA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 5 TYR A 426
ILE A 408
LEU A 443
LEU A 434
None
1.05A 2zb7A-2pkgA:
undetectable
2zb7A-2pkgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 7 LYS A 163
LEU A 166
PHE A 170
PHE A 128
None
1.00A 2zxwC-2pkgA:
undetectable
2zxwJ-2pkgA:
undetectable
2zxwC-2pkgA:
18.53
2zxwJ-2pkgA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 12 ASN A  22
ILE A  38
ALA A  39
THR A  47
LEU A  55
None
1.09A 3a50A-2pkgA:
undetectable
3a50A-2pkgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 12 ASN A  22
ILE A  38
ALA A  39
THR A  47
LEU A  55
None
1.09A 3a50D-2pkgA:
undetectable
3a50D-2pkgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 12 ASN A  22
ILE A  38
ALA A  39
THR A  47
LEU A  55
None
1.04A 3a51E-2pkgA:
undetectable
3a51E-2pkgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 8 LYS A 163
LEU A 166
PHE A 170
PHE A 128
None
0.95A 3asoC-2pkgA:
undetectable
3asoJ-2pkgA:
undetectable
3asoC-2pkgA:
18.53
3asoJ-2pkgA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 4 PHE A 192
TYR A 169
VAL A 220
LEU A 223
None
1.38A 3keeD-2pkgA:
0.0
3keeD-2pkgA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 10 LEU A 567
ALA A 582
GLY A 548
ILE A 547
LEU A 564
None
1.06A 3ogpB-2pkgA:
undetectable
3ogpB-2pkgA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 10 LEU A 567
ALA A 582
GLY A 548
ILE A 547
LEU A 564
None
1.02A 3ogpA-2pkgA:
undetectable
3ogpA-2pkgA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 7 ILE A  32
LEU A  69
SER A 111
LEU A  93
VAL A  86
None
1.33A 3r9vA-2pkgA:
undetectable
3r9vB-2pkgA:
undetectable
3r9vA-2pkgA:
17.92
3r9vB-2pkgA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 7 LEU A 567
ALA A 582
GLY A 548
ILE A 547
None
0.80A 3spkB-2pkgA:
undetectable
3spkB-2pkgA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 8 GLY A 357
SER A 353
ILE A 395
LEU A 366
VAL A 391
None
1.36A 3v1nA-2pkgA:
undetectable
3v1nA-2pkgA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 8 LEU A 373
VAL A 419
TYR A 426
LEU A 404
None
1.02A 3v81A-2pkgA:
undetectable
3v81A-2pkgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 12 THR A 481
ILE A 482
ILE A 424
ALA A 412
PHE A 439
None
1.19A 3vw1B-2pkgA:
undetectable
3vw1B-2pkgA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 12 THR A 481
ILE A 482
ILE A 424
ALA A 412
PHE A 439
None
1.16A 3vw1D-2pkgA:
undetectable
3vw1D-2pkgA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 8 LEU A 373
VAL A 419
TYR A 426
LEU A 404
None
1.00A 4puoC-2pkgA:
undetectable
4puoC-2pkgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 11 LEU A 544
PHE A 538
GLY A 530
LEU A 564
ALA A 579
None
1.22A 4wnuA-2pkgA:
undetectable
4wnuA-2pkgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 4 LEU A 551
ILE A 547
PRO A 523
LEU A 526
None
0.99A 5eb3A-2pkgA:
undetectable
5eb3A-2pkgA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
3 / 3 ALA A 286
ASN A 289
LEU A 290
None
0.48A 5i1nC-2pkgA:
undetectable
5i1nC-2pkgA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
3 / 3 ALA A 286
ASN A 289
LEU A 290
None
0.38A 5i1pA-2pkgA:
undetectable
5i1pA-2pkgA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
3 / 3 ALA A 286
ASN A 289
LEU A 290
None
0.46A 5i1pD-2pkgA:
undetectable
5i1pD-2pkgA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
3 / 3 HIS A 119
HIS A  87
HIS A 127
None
1.00A 5oexA-2pkgA:
undetectable
5oexA-2pkgA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
3 / 3 CYH A 174
MET A 208
ASN A 211
None
1.27A 5qh8A-2pkgA:
undetectable
5qh8A-2pkgA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
4 / 6 LYS A 163
LEU A 166
PHE A 170
PHE A 128
None
0.96A 5w97C-2pkgA:
2.4
5w97J-2pkgA:
undetectable
5w97C-2pkgA:
18.53
5w97J-2pkgA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
2pkg SMALL T ANTIGEN
(Macaca
mulatta
polyomavirus
1)
3 / 3 ARG C 119
PHE C 144
LEU C 115
None
0.86A 5x1bC-2pkgC:
undetectable
5x1bC-2pkgC:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 11 ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
None
1.32A 6dlzA-2pkgA:
3.0
6dlzD-2pkgA:
undetectable
6dlzA-2pkgA:
10.18
6dlzD-2pkgA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo
sapiens)
5 / 11 ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
None
1.33A 6dm1A-2pkgA:
2.8
6dm1D-2pkgA:
undetectable
6dm1A-2pkgA:
10.18
6dm1D-2pkgA:
10.18