SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ALA A 231
VAL A 229
TRP A 223
 None
 0.92A 1grmA-2pkhA:
undetectable		 1grmA-2pkhA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ALA A 231
VAL A 229
TRP A 223
 None
 0.92A 1grmB-2pkhA:
undetectable		 1grmB-2pkhA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 LEU A 207
MET A 115
LEU A 142
GLN A 153
 None
EDO  A1009 ( 4.6A)
None
EDO  A1001 ( 3.6A)
 1.47A 1p93D-2pkhA:
undetectable		 1p93D-2pkhA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.93A 1q23B-2pkhA:
undetectable		 1q23B-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.94A 1q23C-2pkhA:
undetectable		 1q23C-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.98A 1q23E-2pkhA:
undetectable		 1q23E-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.95A 1q23F-2pkhA:
undetectable		 1q23F-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.93A 1q23H-2pkhA:
undetectable
1q23I-2pkhA:
undetectable		 1q23H-2pkhA:
18.26
1q23I-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.96A 1q23I-2pkhA:
undetectable		 1q23I-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.95A 1q23K-2pkhA:
undetectable		 1q23K-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 6 ARG A 126
ASP A 156
ILE A 235
LEU A 207
GLU A 200
 None
None
None
None
EDO  A1014 (-4.2A)
 1.44A 2ya7A-2pkhA:
1.2		 2ya7A-2pkhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 6 ARG A 126
ASP A 156
ILE A 235
LEU A 207
GLU A 200
 None
None
None
None
EDO  A1014 (-4.2A)
 1.45A 2ya7B-2pkhA:
1.7		 2ya7B-2pkhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 6 ARG A 126
ASP A 156
ILE A 235
LEU A 207
GLU A 200
 None
None
None
None
EDO  A1014 (-4.2A)
 1.43A 2ya7D-2pkhA:
2.1		 2ya7D-2pkhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.98A 3u9fI-2pkhA:
undetectable		 3u9fI-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.98A 3u9fJ-2pkhA:
undetectable
3u9fK-2pkhA:
undetectable		 3u9fJ-2pkhA:
18.26
3u9fK-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 1.02A 3u9fR-2pkhA:
undetectable		 3u9fR-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 HIS A 140
GLU A 200
ASP A 156
GLU A 195
 None
EDO  A1014 (-4.2A)
None
None
 1.29A 3vywA-2pkhA:
undetectable		 3vywA-2pkhA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 VAL A 184
ARG A 157
TYR A 167
LEU A 130
 None
 1.09A 5umwB-2pkhA:
undetectable
5umwE-2pkhA:
undetectable		 5umwB-2pkhA:
17.33
5umwE-2pkhA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 LEU A 181
VAL A 159
PHE A 139
ASP A 166
 None
 0.73A 5y9mA-2pkhA:
undetectable		 5y9mA-2pkhA:
22.67