SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2pkp HOMOACONITASE SMALL
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 100
ALA A  73
ILE A  72
GLY A  78
PHE A  45
 None
 1.42A 2b17A-2pkpA:
undetectable		 2b17A-2pkpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 2pkp HOMOACONITASE SMALL
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  82
GLY A  62
TYR A  92
SER A  65
ARG A  67
 None
 1.42A 2zthA-2pkpA:
2.2		 2zthA-2pkpA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2pkp HOMOACONITASE SMALL
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 147
ALA A 149
ILE A 146
LEU A 152
VAL A  98
 None
 1.16A 3gyqB-2pkpA:
undetectable		 3gyqB-2pkpA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2pkp HOMOACONITASE SMALL
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  79
LEU A 100
ILE A  83
GLY A  62
 None
 0.81A 4hb6A-2pkpA:
undetectable		 4hb6A-2pkpA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 2pkp HOMOACONITASE SMALL
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 ASP A  15
GLU A  68
VAL A  71
ILE A  74
PHE A  61
 None
 1.32A 4qt2A-2pkpA:
undetectable		 4qt2A-2pkpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2pkp HOMOACONITASE SMALL
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A  54
LEU A 120
ILE A 101
ALA A 105
 None
 0.78A 4zf8A-2pkpA:
undetectable		 4zf8A-2pkpA:
16.38