SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 9 GLU A  57
ASP A  58
ARG A  65
ILE A  63
ILE A  75
 None
 0.89A 1aj6A-2pl1A:
undetectable		 1aj6A-2pl1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		3 / 3 ASP A   8
LEU A  52
LEU A  54
 MG  A 204 (-2.6A)
BEF  A 205 (-4.3A)
None
 0.69A 1ikeA-2pl1A:
undetectable		 1ikeA-2pl1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 GLU A  57
ASP A  58
ARG A  65
ILE A  63
ILE A  75
 None
 0.92A 1kijA-2pl1A:
undetectable		 1kijA-2pl1A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 GLU A  57
ASP A  58
ARG A  65
ILE A  63
ILE A  75
 None
 0.99A 1kijB-2pl1A:
undetectable		 1kijB-2pl1A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		3 / 3 ASP A   8
LEU A  52
LEU A  54
 MG  A 204 (-2.6A)
BEF  A 205 (-4.3A)
None
 0.75A 1np1B-2pl1A:
undetectable		 1np1B-2pl1A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 LEU A  60
GLY A  94
ALA A  95
ASP A  96
VAL A  50
 None
 1.06A 2f8gA-2pl1A:
undetectable		 2f8gA-2pl1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 LEU A  60
GLY A  94
ALA A  95
ASP A  96
VAL A  50
 None
 1.07A 3d1zB-2pl1A:
undetectable		 3d1zB-2pl1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 11 ALA A  36
ASP A  32
GLY A  59
ILE A  63
ILE A  49
 None
 1.04A 3ebzB-2pl1A:
undetectable		 3ebzB-2pl1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 11 LEU A  60
GLY A  94
ALA A  95
ASP A  96
VAL A  50
 None
 1.08A 3ektD-2pl1A:
undetectable		 3ektD-2pl1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		4 / 8 GLY A  94
ALA A  95
ASP A  96
THR A  79
 None
None
None
BEF  A 205 (-3.5A)
 0.64A 3el0A-2pl1A:
undetectable		 3el0A-2pl1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 LEU A  60
GLY A  94
ALA A  95
ASP A  96
VAL A  50
 None
 1.06A 3mwsA-2pl1A:
undetectable		 3mwsA-2pl1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 LEU A  60
GLY A  94
ALA A  95
ASP A  96
VAL A  50
 None
 1.06A 3oxxA-2pl1A:
undetectable		 3oxxA-2pl1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		3 / 3 LEU A  62
ILE A  63
ARG A  67
 None
 0.45A 4mk4B-2pl1A:
5.2		 4mk4B-2pl1A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 10 LEU A  60
GLY A  94
ALA A  95
ASP A  96
VAL A  50
 None
 1.01A 4njtB-2pl1A:
undetectable		 4njtB-2pl1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 9 LEU A  60
GLY A  94
ALA A  95
ASP A  96
VAL A  50
 None
 1.01A 4njtD-2pl1A:
undetectable		 4njtD-2pl1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 GLU A  57
ASP A  58
ARG A  65
ILE A  63
ILE A  75
 None
 0.85A 4uroA-2pl1A:
undetectable		 4uroA-2pl1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 GLU A  57
ASP A  58
ARG A  65
ILE A  63
ILE A  75
 None
 0.86A 4uroB-2pl1A:
undetectable		 4uroB-2pl1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 GLU A  57
ASP A  58
ARG A  65
ILE A  63
ILE A  75
 None
 0.82A 4uroC-2pl1A:
undetectable		 4uroC-2pl1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 GLU A  57
ASP A  58
ARG A  65
ILE A  63
ILE A  75
 None
 0.91A 4uroD-2pl1A:
undetectable		 4uroD-2pl1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		5 / 12 LEU A  60
GLY A  94
ALA A  95
ASP A  96
VAL A  50
 None
 1.04A 5t2zA-2pl1A:
undetectable		 5t2zA-2pl1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP
(Escherichia
coli) 		4 / 8 LEU A  76
VAL A  50
LEU A  91
ILE A  63
 None
 0.94A 5v0vA-2pl1A:
undetectable		 5v0vA-2pl1A:
12.78