SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		5 / 12 GLU A 105
LEU A  74
GLY A  86
TYR A  67
GLY A  99
 None
 1.18A 1httC-2pl2A:
undetectable		 1httC-2pl2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		4 / 5 LEU A 181
ALA A 194
LEU A 184
SER A 187
 None
 1.13A 1tt6B-2pl2A:
undetectable		 1tt6B-2pl2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		5 / 12 LEU A  66
LEU A  69
ALA A  70
GLN A  73
THR A  93
 None
 1.05A 1ya3C-2pl2A:
undetectable		 1ya3C-2pl2A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		5 / 12 LEU A  66
LEU A  69
ALA A  70
GLN A  73
THR A  93
 None
 1.14A 2aa6A-2pl2A:
undetectable		 2aa6A-2pl2A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		5 / 9 LEU A 211
GLU A 183
ALA A 194
GLU A 162
LEU A 165
 None
 1.39A 2azqA-2pl2A:
undetectable		 2azqA-2pl2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		3 / 3 LEU A  42
LEU A  39
ARG A  34
 None
 0.75A 3hcnB-2pl2A:
undetectable		 3hcnB-2pl2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		5 / 12 LEU A  66
LEU A  69
ALA A  70
GLN A  73
THR A  93
 None
 1.08A 4fn9A-2pl2A:
undetectable		 4fn9A-2pl2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		5 / 12 LEU A  66
LEU A  69
ALA A  70
GLN A  73
THR A  93
 None
 0.96A 4fn9B-2pl2A:
undetectable		 4fn9B-2pl2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		4 / 7 LEU A 181
ALA A 194
LEU A 184
SER A 187
 None
 1.16A 4iklA-2pl2A:
undetectable
4iklB-2pl2A:
undetectable		 4iklA-2pl2A:
20.19
4iklB-2pl2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		5 / 11 LEU A 154
LEU A  74
LEU A 124
ALA A 127
SER A 104
 None
 1.11A 4wnuA-2pl2A:
undetectable		 4wnuA-2pl2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		5 / 9 LEU A 110
ALA A 106
VAL A 102
GLU A  84
LYS A  87
 None
 1.16A 5dbyA-2pl2A:
1.5		 5dbyA-2pl2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		3 / 3 GLU A 193
ARG A 190
TYR A 185
 None
 0.63A 5trqB-2pl2A:
undetectable		 5trqB-2pl2A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		3 / 3 ALA A  91
VAL A 130
TYR A 100
 None
 0.63A 5zmqH-2pl2A:
undetectable		 5zmqH-2pl2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263
(Thermus
thermophilus) 		4 / 8 LEU A 150
GLY A 149
LEU A 165
GLU A 183
 None
 0.82A 6mdqA-2pl2A:
1.8		 6mdqA-2pl2A:
17.62