SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		4 / 4 THR A 120
LEU A 124
VAL A 127
LEU A 131
 ADP  A 300 (-3.6A)
None
None
None
 0.81A 1fbmD-2pl3A:
undetectable		 1fbmD-2pl3A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		4 / 5 THR A 120
LEU A 124
VAL A 127
LEU A 131
 ADP  A 300 (-3.6A)
None
None
None
 0.75A 1fbmE-2pl3A:
undetectable		 1fbmE-2pl3A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		4 / 4 THR A 120
LEU A 124
VAL A 127
LEU A 131
 ADP  A 300 (-3.6A)
None
None
None
 0.79A 1mz9D-2pl3A:
undetectable		 1mz9D-2pl3A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 8 SER A 210
PHE A 211
LEU A 201
LEU A 243
LEU A 216
 None
 1.45A 2bfpC-2pl3A:
2.1		 2bfpC-2pl3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		4 / 7 GLY A 173
ILE A 146
THR A 157
LEU A 174
 None
 1.02A 2xrhA-2pl3A:
undetectable		 2xrhA-2pl3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 12 ARG A 162
GLY A  83
GLY A 165
ALA A  87
TYR A  89
 None
None
None
None
ADP  A 300 (-4.6A)
 1.25A 3sxjA-2pl3A:
3.1		 3sxjA-2pl3A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 12 ARG A 162
GLY A  83
GLY A 165
ALA A  87
TYR A  89
 None
None
None
None
ADP  A 300 (-4.6A)
 1.25A 3sxjB-2pl3A:
2.2		 3sxjB-2pl3A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 12 ARG A 162
GLY A  83
GLY A 165
ALA A  87
TYR A  89
 None
None
None
None
ADP  A 300 (-4.6A)
 1.28A 3t7sC-2pl3A:
3.1		 3t7sC-2pl3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 12 LEU A 251
LEU A 263
LEU A 266
VAL A 239
THR A 249
 None
EOH  A 403 (-3.9A)
EOH  A 403 (-4.0A)
None
None
 1.39A 3zqtA-2pl3A:
undetectable		 3zqtA-2pl3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 12 VAL A 195
VAL A 220
ALA A 224
GLU A 223
LEU A 153
 None
None
None
MG  A 301 ( 3.0A)
EOH  A 400 (-4.7A)
 1.06A 4i1rA-2pl3A:
undetectable		 4i1rA-2pl3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 12 ILE A 240
VAL A 239
LEU A 202
LEU A 243
LEU A 221
 None
 1.27A 4m11C-2pl3A:
undetectable		 4m11C-2pl3A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 12 GLY A 101
VAL A 127
ARG A 133
MET A 218
ILE A  95
 None
 1.24A 4oktA-2pl3A:
undetectable		 4oktA-2pl3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		3 / 3 LEU A  76
LEU A 104
ARG A  50
 None
 0.46A 5hnzB-2pl3A:
2.6		 5hnzB-2pl3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		4 / 6 VAL A 239
THR A 235
LEU A 145
LEU A 250
 None
 0.92A 5tudD-2pl3A:
undetectable		 5tudD-2pl3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		4 / 5 VAL A 239
THR A 235
LEU A 219
LEU A 268
 None
 0.90A 6bqgA-2pl3A:
undetectable		 6bqgA-2pl3A:
17.17