SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 0.99A 1v55C-2pl5A:
undetectable
1v55N-2pl5A:
undetectable
1v55P-2pl5A:
undetectable		 1v55C-2pl5A:
22.13
1v55N-2pl5A:
21.46
1v55P-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		5 / 12 GLU A 337
SER A 340
VAL A 323
TYR A 335
VAL A 305
 None
 1.43A 1x70A-2pl5A:
16.7		 1x70A-2pl5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		5 / 12 GLU A 337
SER A 340
VAL A 323
TYR A 335
VAL A 305
 None
 1.44A 1x70B-2pl5A:
15.8		 1x70B-2pl5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		5 / 12 GLY A 206
GLY A 119
LEU A 108
GLY A 106
PRO A 112
 None
None
GOL  A 400 (-4.0A)
GOL  A 400 (-3.3A)
None
 1.23A 1y4lA-2pl5A:
undetectable		 1y4lA-2pl5A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 0.96A 3ablA-2pl5A:
undetectable
3ablC-2pl5A:
undetectable
3ablP-2pl5A:
undetectable		 3ablA-2pl5A:
21.46
3ablC-2pl5A:
22.13
3ablP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 0.96A 3ablC-2pl5A:
undetectable
3ablN-2pl5A:
undetectable
3ablP-2pl5A:
undetectable		 3ablC-2pl5A:
22.13
3ablN-2pl5A:
21.46
3ablP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 0.98A 3abmA-2pl5A:
undetectable
3abmC-2pl5A:
undetectable
3abmP-2pl5A:
undetectable		 3abmA-2pl5A:
21.46
3abmC-2pl5A:
22.13
3abmP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 0.99A 3asnC-2pl5A:
undetectable
3asnN-2pl5A:
undetectable
3asnP-2pl5A:
undetectable		 3asnC-2pl5A:
22.13
3asnN-2pl5A:
21.46
3asnP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 1.04A 3asoA-2pl5A:
undetectable
3asoC-2pl5A:
undetectable
3asoP-2pl5A:
undetectable		 3asoA-2pl5A:
21.46
3asoC-2pl5A:
22.13
3asoP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.02A 3asoC-2pl5A:
undetectable
3asoN-2pl5A:
undetectable
3asoP-2pl5A:
undetectable		 3asoC-2pl5A:
22.13
3asoN-2pl5A:
21.46
3asoP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 5 LEU A 286
GLN A 158
LEU A 160
GLU A 161
 None
 0.89A 3h5gA-2pl5A:
undetectable
3h5gB-2pl5A:
undetectable		 3h5gA-2pl5A:
6.28
3h5gB-2pl5A:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		5 / 12 ILE A  98
GLY A  99
GLY A 100
ALA A 280
PRO A 123
 None
 0.95A 3jb2A-2pl5A:
undetectable		 3jb2A-2pl5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		5 / 12 SER A 104
PHE A 347
ILE A  33
ALA A 133
GLY A 155
 None
 0.91A 3nxuA-2pl5A:
undetectable		 3nxuA-2pl5A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 6 GLY A 155
GLY A 152
TRP A  75
LEU A 348
 None
 0.78A 3o9mB-2pl5A:
14.8		 3o9mB-2pl5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 ILE A  93
GLU A  36
ALA A  61
ALA A  62
 None
 0.81A 3r9tB-2pl5A:
undetectable		 3r9tB-2pl5A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		5 / 8 GLY A 151
GLY A 156
ILE A 127
LEU A 281
VAL A  97
 None
 0.95A 3v1nA-2pl5A:
22.6		 3v1nA-2pl5A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 1.03A 3x2qA-2pl5A:
undetectable
3x2qC-2pl5A:
undetectable
3x2qP-2pl5A:
undetectable		 3x2qA-2pl5A:
21.46
3x2qC-2pl5A:
22.13
3x2qP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.00A 3x2qC-2pl5A:
undetectable
3x2qN-2pl5A:
undetectable
3x2qP-2pl5A:
undetectable		 3x2qC-2pl5A:
22.13
3x2qN-2pl5A:
21.46
3x2qP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		5 / 12 LEU A 281
HIS A  53
GLY A 152
LEU A  55
GLY A  57
 None
 1.04A 4blvA-2pl5A:
undetectable		 4blvA-2pl5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		5 / 7 LEU A 348
HIS A  53
ALA A  54
TYR A 314
ALA A 177
 None
 1.36A 4g77A-2pl5A:
undetectable		 4g77A-2pl5A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		5 / 10 MET A 176
TRP A  75
ILE A  79
ALA A  61
ALA A  54
 None
 1.49A 4xk8B-2pl5A:
0.0		 4xk8B-2pl5A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 TYR A 208
GLY A 119
ILE A  98
SER A 104
 None
 0.83A 5alcL-2pl5A:
undetectable		 5alcL-2pl5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 0.94A 5b1bA-2pl5A:
undetectable
5b1bC-2pl5A:
undetectable
5b1bP-2pl5A:
undetectable		 5b1bA-2pl5A:
21.46
5b1bC-2pl5A:
22.13
5b1bP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.01A 5iy5C-2pl5A:
undetectable
5iy5N-2pl5A:
undetectable
5iy5P-2pl5A:
undetectable		 5iy5C-2pl5A:
21.60
5iy5N-2pl5A:
21.46
5iy5P-2pl5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		3 / 3 GLY A  82
ASP A  86
ASN A  47
 None
 0.55A 5jglA-2pl5A:
undetectable		 5jglA-2pl5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 5 ASP A 270
GLY A 119
PRO A 107
CYH A 101
 None
None
GOL  A 400 (-4.0A)
None
 1.49A 5nn8A-2pl5A:
0.0		 5nn8A-2pl5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 6 TYR A  78
ASP A  76
TRP A  75
TYR A 308
 None
 1.32A 5ov9A-2pl5A:
12.6		 5ov9A-2pl5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 TYR A  78
ASP A  76
TRP A  75
TYR A 308
 None
 1.35A 5ov9B-2pl5A:
14.7		 5ov9B-2pl5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 4 HIS A  65
HIS A  60
TYR A  38
GLU A  36
 None
 1.22A 5pahA-2pl5A:
undetectable		 5pahA-2pl5A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 1.05A 5w97A-2pl5A:
undetectable
5w97C-2pl5A:
undetectable
5w97c-2pl5A:
undetectable		 5w97A-2pl5A:
21.46
5w97C-2pl5A:
22.13
5w97c-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.09A 5w97C-2pl5A:
undetectable
5w97a-2pl5A:
undetectable
5w97c-2pl5A:
undetectable		 5w97C-2pl5A:
22.13
5w97a-2pl5A:
21.46
5w97c-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 1.01A 5wauA-2pl5A:
undetectable
5wauC-2pl5A:
undetectable
5wauc-2pl5A:
undetectable		 5wauA-2pl5A:
21.46
5wauC-2pl5A:
22.13
5wauc-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 0.97A 5wauC-2pl5A:
undetectable
5waua-2pl5A:
undetectable
5wauc-2pl5A:
undetectable		 5wauC-2pl5A:
22.13
5waua-2pl5A:
21.46
5wauc-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 0.98A 5x19A-2pl5A:
undetectable
5x19C-2pl5A:
undetectable
5x19P-2pl5A:
undetectable		 5x19A-2pl5A:
21.46
5x19C-2pl5A:
22.13
5x19P-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 0.93A 5x1bA-2pl5A:
undetectable
5x1bC-2pl5A:
undetectable
5x1bP-2pl5A:
undetectable		 5x1bA-2pl5A:
21.46
5x1bC-2pl5A:
22.13
5x1bP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 0.97A 5x1fA-2pl5A:
undetectable
5x1fC-2pl5A:
undetectable
5x1fP-2pl5A:
undetectable		 5x1fA-2pl5A:
21.46
5x1fC-2pl5A:
22.13
5x1fP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 1.05A 5xdqA-2pl5A:
undetectable
5xdqC-2pl5A:
undetectable
5xdqP-2pl5A:
undetectable		 5xdqA-2pl5A:
21.46
5xdqC-2pl5A:
22.13
5xdqP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.02A 5xdqC-2pl5A:
undetectable
5xdqN-2pl5A:
undetectable
5xdqP-2pl5A:
undetectable		 5xdqC-2pl5A:
22.13
5xdqN-2pl5A:
21.46
5xdqP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.01A 5xdxC-2pl5A:
undetectable
5xdxN-2pl5A:
undetectable
5xdxP-2pl5A:
undetectable		 5xdxC-2pl5A:
21.60
5xdxN-2pl5A:
21.46
5xdxP-2pl5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.01A 5z84C-2pl5A:
undetectable
5z84N-2pl5A:
undetectable
5z84P-2pl5A:
undetectable		 5z84C-2pl5A:
22.13
5z84N-2pl5A:
21.46
5z84P-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.03A 5z85C-2pl5A:
undetectable
5z85N-2pl5A:
undetectable
5z85P-2pl5A:
undetectable		 5z85C-2pl5A:
22.13
5z85N-2pl5A:
21.46
5z85P-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.03A 5z86C-2pl5A:
undetectable
5z86N-2pl5A:
undetectable
5z86P-2pl5A:
undetectable		 5z86C-2pl5A:
22.13
5z86N-2pl5A:
21.46
5z86P-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.03A 5zcoC-2pl5A:
undetectable
5zcoN-2pl5A:
undetectable
5zcoP-2pl5A:
undetectable		 5zcoC-2pl5A:
22.13
5zcoN-2pl5A:
21.46
5zcoP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 1.03A 5zcpC-2pl5A:
undetectable
5zcpN-2pl5A:
undetectable
5zcpP-2pl5A:
undetectable		 5zcpC-2pl5A:
22.13
5zcpN-2pl5A:
21.46
5zcpP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 LEU A 362
ASP A  86
THR A  87
HIS A  60
 None
 0.99A 6nknC-2pl5A:
undetectable
6nknN-2pl5A:
0.2
6nknP-2pl5A:
undetectable		 6nknC-2pl5A:
22.13
6nknN-2pl5A:
21.46
6nknP-2pl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pl5 HOMOSERINE
O-ACETYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 ASP A  86
THR A  87
HIS A  60
LEU A 362
 None
 0.92A 6nmfA-2pl5A:
undetectable
6nmfC-2pl5A:
undetectable
6nmfP-2pl5A:
undetectable		 6nmfA-2pl5A:
21.46
6nmfC-2pl5A:
22.13
6nmfP-2pl5A:
22.13